Disseminated adenovirus infection in heart and kidney transplant
Presently described is a case of disseminated adenovirus infection in a heart-kidney transplant recipient that was successfully treated with cidofovir. There are several reports of adenovirus infections in adult solid organ transplant recipients and the prognosis is usually poor, with mortality rate...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KARE Publishing
2018-04-01
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| Series: | Türk Kardiyoloji Derneği Arşivi |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-74957 |
| _version_ | 1797907079227244544 |
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| author | Jack Xu Keval V Patel Melroy Dsouza Jesus Almendral Kanika Mody Deepa Iyer |
| author_facet | Jack Xu Keval V Patel Melroy Dsouza Jesus Almendral Kanika Mody Deepa Iyer |
| author_sort | Jack Xu |
| collection | DOAJ |
| description | Presently described is a case of disseminated adenovirus infection in a heart-kidney transplant recipient that was successfully treated with cidofovir. There are several reports of adenovirus infections in adult solid organ transplant recipients and the prognosis is usually poor, with mortality rates of 40% to 60%. Severe disseminated adenovirus infections have been associated with increased risk of adverse transplant events, such as rejection, ventricular dysfunction, allograft vasculopathy, graft loss, and the need for re-transplantation. The patient's lack of clinical improvement, the onset of hemorrhagic cystitis and acute kidney injury were factors in our decision to temporarily discontinue administration of immunosuppressive agents and start an antiviral agent. It is important to suspect adenovirus in transplant patients when they do not respond to antibiotics and cultures are negative. Early diagnosis and treatment are critical to improving outcomes in immunocompromised patients. |
| first_indexed | 2024-04-10T10:30:46Z |
| format | Article |
| id | doaj.art-42c2190aa4af4f0a8d97209f4c0850c5 |
| institution | Directory Open Access Journal |
| issn | 1016-5169 |
| language | English |
| last_indexed | 2024-04-10T10:30:46Z |
| publishDate | 2018-04-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Türk Kardiyoloji Derneği Arşivi |
| spelling | doaj.art-42c2190aa4af4f0a8d97209f4c0850c52023-02-15T16:21:08ZengKARE PublishingTürk Kardiyoloji Derneği Arşivi1016-51692018-04-0146323123310.5543/tkda.2017.74957TKDA-74957Disseminated adenovirus infection in heart and kidney transplantJack Xu0Keval V Patel1Melroy Dsouza2Jesus Almendral3Kanika Mody4Deepa Iyer5Department of Internal Medicine, Rutgers Robert Wood Johnson University Hospital, New Brunswick, NJ, USADepartment of Cardiology, Rutgers Robert Wood Johnson University Hospital, New Brunswick, NJ, USADepartment of Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USADepartment of Cardiology, Rutgers Robert Wood Johnson University Hospital, New Brunswick, NJ, USADepartment of Cardiology, Rutgers Robert Wood Johnson University Hospital, New Brunswick, NJ, USADepartment of Cardiology, Rutgers Robert Wood Johnson University Hospital, New Brunswick, NJ, USAPresently described is a case of disseminated adenovirus infection in a heart-kidney transplant recipient that was successfully treated with cidofovir. There are several reports of adenovirus infections in adult solid organ transplant recipients and the prognosis is usually poor, with mortality rates of 40% to 60%. Severe disseminated adenovirus infections have been associated with increased risk of adverse transplant events, such as rejection, ventricular dysfunction, allograft vasculopathy, graft loss, and the need for re-transplantation. The patient's lack of clinical improvement, the onset of hemorrhagic cystitis and acute kidney injury were factors in our decision to temporarily discontinue administration of immunosuppressive agents and start an antiviral agent. It is important to suspect adenovirus in transplant patients when they do not respond to antibiotics and cultures are negative. Early diagnosis and treatment are critical to improving outcomes in immunocompromised patients.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-74957disseminated adenovirusheart and kidney transplant; transplant recipient. |
| spellingShingle | Jack Xu Keval V Patel Melroy Dsouza Jesus Almendral Kanika Mody Deepa Iyer Disseminated adenovirus infection in heart and kidney transplant Türk Kardiyoloji Derneği Arşivi disseminated adenovirus heart and kidney transplant; transplant recipient. |
| title | Disseminated adenovirus infection in heart and kidney transplant |
| title_full | Disseminated adenovirus infection in heart and kidney transplant |
| title_fullStr | Disseminated adenovirus infection in heart and kidney transplant |
| title_full_unstemmed | Disseminated adenovirus infection in heart and kidney transplant |
| title_short | Disseminated adenovirus infection in heart and kidney transplant |
| title_sort | disseminated adenovirus infection in heart and kidney transplant |
| topic | disseminated adenovirus heart and kidney transplant; transplant recipient. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-74957 |
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