Distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposure
The chronic effects of low doses of cadmium on the distribution of soluble and filament forms of glial fibrillary acidic protein (GFAP) and their polypeptide fragments in different parts of the rat brain were investigated. Obtained results showed dose-dependent effect of cadmium on the soluble form...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2015-06-01
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| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2015/07/Kovalchuk_3_15.pdf |
| _version_ | 1827775459284221952 |
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| author | Yu. P. Kovalchuk I. V. Prischepa U. Si V. S. Nedzvetsky Y. G. Kot E. E. Persky G. A. Ushakova |
| author_facet | Yu. P. Kovalchuk I. V. Prischepa U. Si V. S. Nedzvetsky Y. G. Kot E. E. Persky G. A. Ushakova |
| author_sort | Yu. P. Kovalchuk |
| collection | DOAJ |
| description | The chronic effects of low doses of cadmium on the distribution of soluble and filament forms of glial fibrillary acidic protein (GFAP) and their polypeptide fragments in different parts of the rat brain were investigated. Obtained results showed dose-dependent effect of cadmium on the soluble form of GFAP and more pronounced effect on the filament form and composition of the polypeptide fragments of the protein in the rat brain. Prolonged intoxication by cadmium ions in a dose of 1.0 µg/kg of body weight induced a significant decrease in soluble GFAP and an increase in the filament form in the rat brain, pointing to the development of reactive astrogliosis and the risk of neurodegeneration. |
| first_indexed | 2024-03-11T13:50:00Z |
| format | Article |
| id | doaj.art-42c56bce65384eb8811c789bb0b1ba50 |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-11T13:50:00Z |
| publishDate | 2015-06-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-42c56bce65384eb8811c789bb0b1ba502023-11-02T09:08:07ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032015-06-0187311612310.15407/ubj87.03.116Distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposureYu. P. Kovalchuk0I. V. Prischepa1U. Si2V. S. Nedzvetsky3Y. G. Kot4E. E. Persky5G. A. Ushakova6Oles’ Honchar Dnepropetrovsk National University, UkraineOles’ Honchar Dnepropetrovsk National University, Ukraine V. N. Karazin Kharkiv National University, UkraineOles’ Honchar Dnepropetrovsk National University, UkraineV. N. Karazin Kharkiv National University, UkraineV. N. Karazin Kharkiv National University, UkraineOles’ Honchar Dnepropetrovsk National University, UkraineThe chronic effects of low doses of cadmium on the distribution of soluble and filament forms of glial fibrillary acidic protein (GFAP) and their polypeptide fragments in different parts of the rat brain were investigated. Obtained results showed dose-dependent effect of cadmium on the soluble form of GFAP and more pronounced effect on the filament form and composition of the polypeptide fragments of the protein in the rat brain. Prolonged intoxication by cadmium ions in a dose of 1.0 µg/kg of body weight induced a significant decrease in soluble GFAP and an increase in the filament form in the rat brain, pointing to the development of reactive astrogliosis and the risk of neurodegeneration.http://ukrbiochemjournal.org/wp-content/uploads/2015/07/Kovalchuk_3_15.pdfcadmiumglial fibrillary acid proteinrat brain |
| spellingShingle | Yu. P. Kovalchuk I. V. Prischepa U. Si V. S. Nedzvetsky Y. G. Kot E. E. Persky G. A. Ushakova Distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposure The Ukrainian Biochemical Journal cadmium glial fibrillary acid protein rat brain |
| title | Distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposure |
| title_full | Distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposure |
| title_fullStr | Distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposure |
| title_full_unstemmed | Distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposure |
| title_short | Distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposure |
| title_sort | distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposure |
| topic | cadmium glial fibrillary acid protein rat brain |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2015/07/Kovalchuk_3_15.pdf |
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