Sargassum wightii ameliorates anxiety-like behaviour and cognitive deficits in rotenone-induced parkinsonian rats
Introduction: Parkinson’s disease (PD) is a neurodegenerative disorder, basically manifested by motor symptoms. However, there are other associated non-motor features in PD, including depression, anxiety, and cognitive impairments that significantly affect the quality of life. Scientific reports hav...
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| Format: | Article |
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Shahrekord University of Medical Sciences
2023-06-01
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| Series: | Journal of HerbMed Pharmacology |
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| Online Access: | http://herbmedpharmacol.com/PDF/jhp-12-419.pdf |
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| author | Bandana Rath Lalit Mohan Sika Ikhita Misra Snigdha Rani Panigrahy Baidyanath Mishra |
| author_facet | Bandana Rath Lalit Mohan Sika Ikhita Misra Snigdha Rani Panigrahy Baidyanath Mishra |
| author_sort | Bandana Rath |
| collection | DOAJ |
| description | Introduction: Parkinson’s disease (PD) is a neurodegenerative disorder, basically manifested by motor symptoms. However, there are other associated non-motor features in PD, including depression, anxiety, and cognitive impairments that significantly affect the quality of life. Scientific reports have shown that Sargassum wightii, a brown seaweed, protects against rotenone-induced motor deficits, mitochondrial dysfunction, and oxidative stress in rats. We therefore, undertook this study to evaluate its efficacy in alleviating rotenone-induced non-motor symptoms such as anxiety-like behavior and cognitive deficits in rats. Methods: Rotenone at a dose of 10 mg/kg was given orally for 28 days to induce PD model in male rats. The vehicle and the test drug were given orally daily, 1 hour prior to the rotenone administration. The protective effect of S. wightii (methanol extract at 400 mg/kg dosage) was assessed through an array of tests: Elevated plus maze test, Morris water maze test, and novel object recognition test. On the 28th day, the rats were sacrificed, and hippocampal neurobiochemical analyses were performed using high-performance liquid chromatography (HPLC). Results: Co-administration of S. wightii reversed the rotenone-induced anxiety-like behavior and cognitive deficits to a significant extent (P<0.001). It also restored the hippocampal neurotransmitters (5-hydroxytryptamine, dopamine, and 5-hydroxy indole acetic acid) significantly (P<0.001). Conclusion: Sargassum wightii provides neuroprotective effects and reduces the non-motor symptoms of PD. Therefore, it might be a novel insight into PD therapy. |
| first_indexed | 2024-03-09T15:38:48Z |
| format | Article |
| id | doaj.art-42c6fc1a96d44328a1e76374b36935a5 |
| institution | Directory Open Access Journal |
| issn | 2345-5004 |
| language | English |
| last_indexed | 2024-03-09T15:38:48Z |
| publishDate | 2023-06-01 |
| publisher | Shahrekord University of Medical Sciences |
| record_format | Article |
| series | Journal of HerbMed Pharmacology |
| spelling | doaj.art-42c6fc1a96d44328a1e76374b36935a52023-11-25T08:27:27ZengShahrekord University of Medical SciencesJournal of HerbMed Pharmacology2345-50042023-06-0112341942410.34172/jhp.2023.46jhp-44907Sargassum wightii ameliorates anxiety-like behaviour and cognitive deficits in rotenone-induced parkinsonian ratsBandana Rath0Lalit Mohan Sika1Ikhita Misra2Snigdha Rani Panigrahy3Baidyanath Mishra4Department of Pharmacology, SLN MCH, Koraput, Odisha, IndiaDepartment of Pharmacology, SLN MCH, Koraput, Odisha, IndiaDepartment of ENT, SJMCH, Puri, Odisha, IndiaDepartment of Pharmacology, MKCG Medical College, Berhampur, Odisha, IndiaDepartment of Pharmacology, SLN MCH, Koraput, Odisha, IndiaIntroduction: Parkinson’s disease (PD) is a neurodegenerative disorder, basically manifested by motor symptoms. However, there are other associated non-motor features in PD, including depression, anxiety, and cognitive impairments that significantly affect the quality of life. Scientific reports have shown that Sargassum wightii, a brown seaweed, protects against rotenone-induced motor deficits, mitochondrial dysfunction, and oxidative stress in rats. We therefore, undertook this study to evaluate its efficacy in alleviating rotenone-induced non-motor symptoms such as anxiety-like behavior and cognitive deficits in rats. Methods: Rotenone at a dose of 10 mg/kg was given orally for 28 days to induce PD model in male rats. The vehicle and the test drug were given orally daily, 1 hour prior to the rotenone administration. The protective effect of S. wightii (methanol extract at 400 mg/kg dosage) was assessed through an array of tests: Elevated plus maze test, Morris water maze test, and novel object recognition test. On the 28th day, the rats were sacrificed, and hippocampal neurobiochemical analyses were performed using high-performance liquid chromatography (HPLC). Results: Co-administration of S. wightii reversed the rotenone-induced anxiety-like behavior and cognitive deficits to a significant extent (P<0.001). It also restored the hippocampal neurotransmitters (5-hydroxytryptamine, dopamine, and 5-hydroxy indole acetic acid) significantly (P<0.001). Conclusion: Sargassum wightii provides neuroprotective effects and reduces the non-motor symptoms of PD. Therefore, it might be a novel insight into PD therapy.http://herbmedpharmacol.com/PDF/jhp-12-419.pdfneurodegenerative diseaseneuroprotectionnon-motor symptomsneurotransmitterherbal medicine |
| spellingShingle | Bandana Rath Lalit Mohan Sika Ikhita Misra Snigdha Rani Panigrahy Baidyanath Mishra Sargassum wightii ameliorates anxiety-like behaviour and cognitive deficits in rotenone-induced parkinsonian rats Journal of HerbMed Pharmacology neurodegenerative disease neuroprotection non-motor symptoms neurotransmitter herbal medicine |
| title | Sargassum wightii ameliorates anxiety-like behaviour and cognitive deficits in rotenone-induced parkinsonian rats |
| title_full | Sargassum wightii ameliorates anxiety-like behaviour and cognitive deficits in rotenone-induced parkinsonian rats |
| title_fullStr | Sargassum wightii ameliorates anxiety-like behaviour and cognitive deficits in rotenone-induced parkinsonian rats |
| title_full_unstemmed | Sargassum wightii ameliorates anxiety-like behaviour and cognitive deficits in rotenone-induced parkinsonian rats |
| title_short | Sargassum wightii ameliorates anxiety-like behaviour and cognitive deficits in rotenone-induced parkinsonian rats |
| title_sort | sargassum wightii ameliorates anxiety like behaviour and cognitive deficits in rotenone induced parkinsonian rats |
| topic | neurodegenerative disease neuroprotection non-motor symptoms neurotransmitter herbal medicine |
| url | http://herbmedpharmacol.com/PDF/jhp-12-419.pdf |
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