SIRT1 Deficiency, Specifically in Fibroblasts, Decreases Apoptosis Resistance and Is Associated with Resolution of Lung-Fibrosis

SIRT1 Deficiency, Specifically in Fibroblasts, Decreases Apoptosis Resistance and Is Associated with Resolution of Lung-Fibrosis

In contrast to normal regenerating tissue, resistance to Fas- and FasL-positive T cell-induced apoptosis were detected in myofibroblasts from fibrotic-lungs of humans and mice following bleomycin (BLM) exposure. In this study we show, decreased FLIP expression in lung-tissues with resolution of BLM-...

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Bibliographic Details
Main Authors: Raanan Bulvik, Raphael Breuer, Mona Dvir-Ginzberg, Eli Reich, Neville Berkman, Shulamit B. Wallach-Dayan
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Biomolecules
Subjects:
myofibroblasts
SIRT1
cell-death
FLIP
Ku70
IPF-resolution
Online Access:https://www.mdpi.com/2218-273X/10/7/996

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