Smart-Temporary-Film-Based Local-Delivery System with Controllable Drug-Release Behavior
The development of a simple local drug-delivery system that exhibits the advantages of macro- and microscale carriers with controllable drug-release behavior is still highly desired. Herein, in this work, a smart temporary film was prepared from doxorubicin (DOX)-loaded shape-memory microgels via a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/8/12/773 |
| _version_ | 1797458032087531520 |
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| author | Denghang Xie Huiwen Wang Cheng Yin Mengxia Peng Haiyong Ao Jian Hu Yizao Wan Quanchao Zhang |
| author_facet | Denghang Xie Huiwen Wang Cheng Yin Mengxia Peng Haiyong Ao Jian Hu Yizao Wan Quanchao Zhang |
| author_sort | Denghang Xie |
| collection | DOAJ |
| description | The development of a simple local drug-delivery system that exhibits the advantages of macro- and microscale carriers with controllable drug-release behavior is still highly desired. Herein, in this work, a smart temporary film was prepared from doxorubicin (DOX)-loaded shape-memory microgels via a simple hot-compression programming method. The temporary film showed a very smooth surface and easy handing, as well as macroscopy mechanical properties, which could disintegrate into the microgels with heating at 45 °C. In this case, the temporary film showed a controllable DOX release behavior when compared with the microgels, which could release the DOX on demand. Consequently, the temporary film exhibited weaker cytotoxicity to normal cells and a much longer antitumor capability, as well as a higher drug-utilization efficiency when compared with microgels. Therefore, the smart temporary film has high potential as a candidate for use as a local drug-delivery system. |
| first_indexed | 2024-03-09T16:32:11Z |
| format | Article |
| id | doaj.art-42caa0d55b344a098b0e544c44b275a9 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T16:32:11Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-42caa0d55b344a098b0e544c44b275a92023-11-24T15:00:46ZengMDPI AGGels2310-28612022-11-0181277310.3390/gels8120773Smart-Temporary-Film-Based Local-Delivery System with Controllable Drug-Release BehaviorDenghang Xie0Huiwen Wang1Cheng Yin2Mengxia Peng3Haiyong Ao4Jian Hu5Yizao Wan6Quanchao Zhang7Jiangxi Key Laboratory of Nanobiomaterials, Institute of Advanced Materials, East China Jiaotong University, Nanchang 330013, ChinaJiangxi Key Laboratory of Nanobiomaterials, Institute of Advanced Materials, East China Jiaotong University, Nanchang 330013, ChinaJiangxi Key Laboratory of Nanobiomaterials, Institute of Advanced Materials, East China Jiaotong University, Nanchang 330013, ChinaJiangxi Key Laboratory of Nanobiomaterials, Institute of Advanced Materials, East China Jiaotong University, Nanchang 330013, ChinaJiangxi Key Laboratory of Nanobiomaterials, Institute of Advanced Materials, East China Jiaotong University, Nanchang 330013, ChinaJiangxi Key Laboratory of Nanobiomaterials, Institute of Advanced Materials, East China Jiaotong University, Nanchang 330013, ChinaJiangxi Key Laboratory of Nanobiomaterials, Institute of Advanced Materials, East China Jiaotong University, Nanchang 330013, ChinaJiangxi Key Laboratory of Nanobiomaterials, Institute of Advanced Materials, East China Jiaotong University, Nanchang 330013, ChinaThe development of a simple local drug-delivery system that exhibits the advantages of macro- and microscale carriers with controllable drug-release behavior is still highly desired. Herein, in this work, a smart temporary film was prepared from doxorubicin (DOX)-loaded shape-memory microgels via a simple hot-compression programming method. The temporary film showed a very smooth surface and easy handing, as well as macroscopy mechanical properties, which could disintegrate into the microgels with heating at 45 °C. In this case, the temporary film showed a controllable DOX release behavior when compared with the microgels, which could release the DOX on demand. Consequently, the temporary film exhibited weaker cytotoxicity to normal cells and a much longer antitumor capability, as well as a higher drug-utilization efficiency when compared with microgels. Therefore, the smart temporary film has high potential as a candidate for use as a local drug-delivery system.https://www.mdpi.com/2310-2861/8/12/773smarttemporary filmmicrogelscontrollable drug releaselocal delivery system |
| spellingShingle | Denghang Xie Huiwen Wang Cheng Yin Mengxia Peng Haiyong Ao Jian Hu Yizao Wan Quanchao Zhang Smart-Temporary-Film-Based Local-Delivery System with Controllable Drug-Release Behavior Gels smart temporary film microgels controllable drug release local delivery system |
| title | Smart-Temporary-Film-Based Local-Delivery System with Controllable Drug-Release Behavior |
| title_full | Smart-Temporary-Film-Based Local-Delivery System with Controllable Drug-Release Behavior |
| title_fullStr | Smart-Temporary-Film-Based Local-Delivery System with Controllable Drug-Release Behavior |
| title_full_unstemmed | Smart-Temporary-Film-Based Local-Delivery System with Controllable Drug-Release Behavior |
| title_short | Smart-Temporary-Film-Based Local-Delivery System with Controllable Drug-Release Behavior |
| title_sort | smart temporary film based local delivery system with controllable drug release behavior |
| topic | smart temporary film microgels controllable drug release local delivery system |
| url | https://www.mdpi.com/2310-2861/8/12/773 |
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