Treatment of acute aluminum toxicity due to alum bladder irrigation in a hemodialysis patient: a case report
AbstractAcute aluminum toxicity is encountered rarely in clinical practice but carries a high risk for morbidity and mortality. Despite this risk, our understanding of aluminum toxicity and its treatment is relatively limited. Due to decreased clearance, patients with renal failure have increased ri...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Toxicology Communications |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/24734306.2022.2040148 |
| _version_ | 1797805346971975680 |
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| author | David Loughran Diane Calello Lewis Nelson |
| author_facet | David Loughran Diane Calello Lewis Nelson |
| author_sort | David Loughran |
| collection | DOAJ |
| description | AbstractAcute aluminum toxicity is encountered rarely in clinical practice but carries a high risk for morbidity and mortality. Despite this risk, our understanding of aluminum toxicity and its treatment is relatively limited. Due to decreased clearance, patients with renal failure have increased risk for significant aluminum-related central nervous system (CNS) toxicity. Medical advances have limited chronic aluminum exposure in these patients, but they are still at increased risk for acute toxicity from certain aluminum-based interventions such as alum bladder irrigation. We report a case of an 87-year-old man with end-stage renal disease on hemodialysis who developed acute aluminum toxicity from alum bladder irrigation. He was treated with daily deferoxamine infusions followed by dialysis with subsequent resolution of his encephalopathy. This case report uniquely documents trending of blood aluminum concentration (blood [Al]) during treatment providing insight into how aluminum blood concentrations shift during chelation therapy. |
| first_indexed | 2024-03-13T05:50:43Z |
| format | Article |
| id | doaj.art-42cb26129d35436aad8f66ecce3283ed |
| institution | Directory Open Access Journal |
| issn | 2473-4306 |
| language | English |
| last_indexed | 2024-03-13T05:50:43Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Toxicology Communications |
| spelling | doaj.art-42cb26129d35436aad8f66ecce3283ed2023-06-13T12:55:24ZengTaylor & Francis GroupToxicology Communications2473-43062022-12-0161353810.1080/24734306.2022.2040148Treatment of acute aluminum toxicity due to alum bladder irrigation in a hemodialysis patient: a case reportDavid Loughran0Diane Calello1Lewis Nelson2Rutgers New Jersey Medical School, Department of Medical Toxicology, Newark, NJ, USARutgers New Jersey Medical School, Department of Medical Toxicology, New Jersey Poison Information and Education System, Newark, NJ, USARutgers New Jersey Medical School, Department of Medical Toxicology, Newark, NJ, USAAbstractAcute aluminum toxicity is encountered rarely in clinical practice but carries a high risk for morbidity and mortality. Despite this risk, our understanding of aluminum toxicity and its treatment is relatively limited. Due to decreased clearance, patients with renal failure have increased risk for significant aluminum-related central nervous system (CNS) toxicity. Medical advances have limited chronic aluminum exposure in these patients, but they are still at increased risk for acute toxicity from certain aluminum-based interventions such as alum bladder irrigation. We report a case of an 87-year-old man with end-stage renal disease on hemodialysis who developed acute aluminum toxicity from alum bladder irrigation. He was treated with daily deferoxamine infusions followed by dialysis with subsequent resolution of his encephalopathy. This case report uniquely documents trending of blood aluminum concentration (blood [Al]) during treatment providing insight into how aluminum blood concentrations shift during chelation therapy.https://www.tandfonline.com/doi/10.1080/24734306.2022.2040148Aluminum toxicitybladder irrigationhemodialysisdeferoxaminecase report |
| spellingShingle | David Loughran Diane Calello Lewis Nelson Treatment of acute aluminum toxicity due to alum bladder irrigation in a hemodialysis patient: a case report Toxicology Communications Aluminum toxicity bladder irrigation hemodialysis deferoxamine case report |
| title | Treatment of acute aluminum toxicity due to alum bladder irrigation in a hemodialysis patient: a case report |
| title_full | Treatment of acute aluminum toxicity due to alum bladder irrigation in a hemodialysis patient: a case report |
| title_fullStr | Treatment of acute aluminum toxicity due to alum bladder irrigation in a hemodialysis patient: a case report |
| title_full_unstemmed | Treatment of acute aluminum toxicity due to alum bladder irrigation in a hemodialysis patient: a case report |
| title_short | Treatment of acute aluminum toxicity due to alum bladder irrigation in a hemodialysis patient: a case report |
| title_sort | treatment of acute aluminum toxicity due to alum bladder irrigation in a hemodialysis patient a case report |
| topic | Aluminum toxicity bladder irrigation hemodialysis deferoxamine case report |
| url | https://www.tandfonline.com/doi/10.1080/24734306.2022.2040148 |
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