The study of tryptophol containing emulgel on fungal reduction and skin irritation
Abstract Tryptophol (TOH), a fungal quorum-sensing molecule, that possesses anti-fungal activities for controlling the growth of human pathogenic fungi. In the present study, we developed TOH-containing emulgel formulations and examined the antifungal activities and potential use as topical treatmen...
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| Format: | Article |
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Nature Portfolio
2023-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-46121-z |
| _version_ | 1797636885091188736 |
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| author | Thitinan Kitisin Watcharamat Muangkaew Natthawut Thitipramote Arnon Pudgerd Passanesh Sukphopetch |
| author_facet | Thitinan Kitisin Watcharamat Muangkaew Natthawut Thitipramote Arnon Pudgerd Passanesh Sukphopetch |
| author_sort | Thitinan Kitisin |
| collection | DOAJ |
| description | Abstract Tryptophol (TOH), a fungal quorum-sensing molecule, that possesses anti-fungal activities for controlling the growth of human pathogenic fungi. In the present study, we developed TOH-containing emulgel formulations and examined the antifungal activities and potential use as topical treatments on the skin. The results showed that TOH-containing emulgel at 1000 μM has excellent physical characteristics as homogenous, stability, and inhibits the growth of 30 species of human pathogenic fungi in vitro. TOH-containing emulgel did not cause skin irritation in mouse model of irritation and in healthy human volunteers. Moreover, an increase in skin hydration and a decrease in trans-epidermal water loss (TEWL) were observed after TOH-containing emulgel treatment on human skin. Our findings indicated that TOH-containing emulgel can be utilize as an antifungal agent for topical treatment against fungal infections on the skin. |
| first_indexed | 2024-03-11T12:40:28Z |
| format | Article |
| id | doaj.art-42cb96541d164b6181dd48443378654b |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-11T12:40:28Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-42cb96541d164b6181dd48443378654b2023-11-05T12:17:39ZengNature PortfolioScientific Reports2045-23222023-11-0113111210.1038/s41598-023-46121-zThe study of tryptophol containing emulgel on fungal reduction and skin irritationThitinan Kitisin0Watcharamat Muangkaew1Natthawut Thitipramote2Arnon Pudgerd3Passanesh Sukphopetch4Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol UniversityDepartment of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol UniversitySchool of Cosmetic Science, Mae Fah Luang UniversityDivision of Anatomy, School of Medical Science, University of PhayaoDepartment of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol UniversityAbstract Tryptophol (TOH), a fungal quorum-sensing molecule, that possesses anti-fungal activities for controlling the growth of human pathogenic fungi. In the present study, we developed TOH-containing emulgel formulations and examined the antifungal activities and potential use as topical treatments on the skin. The results showed that TOH-containing emulgel at 1000 μM has excellent physical characteristics as homogenous, stability, and inhibits the growth of 30 species of human pathogenic fungi in vitro. TOH-containing emulgel did not cause skin irritation in mouse model of irritation and in healthy human volunteers. Moreover, an increase in skin hydration and a decrease in trans-epidermal water loss (TEWL) were observed after TOH-containing emulgel treatment on human skin. Our findings indicated that TOH-containing emulgel can be utilize as an antifungal agent for topical treatment against fungal infections on the skin.https://doi.org/10.1038/s41598-023-46121-z |
| spellingShingle | Thitinan Kitisin Watcharamat Muangkaew Natthawut Thitipramote Arnon Pudgerd Passanesh Sukphopetch The study of tryptophol containing emulgel on fungal reduction and skin irritation Scientific Reports |
| title | The study of tryptophol containing emulgel on fungal reduction and skin irritation |
| title_full | The study of tryptophol containing emulgel on fungal reduction and skin irritation |
| title_fullStr | The study of tryptophol containing emulgel on fungal reduction and skin irritation |
| title_full_unstemmed | The study of tryptophol containing emulgel on fungal reduction and skin irritation |
| title_short | The study of tryptophol containing emulgel on fungal reduction and skin irritation |
| title_sort | study of tryptophol containing emulgel on fungal reduction and skin irritation |
| url | https://doi.org/10.1038/s41598-023-46121-z |
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