Bone Metastases from Intrahepatic Cholangiocarcinoma Confer Worse Prognosis
Background: Metastatic intrahepatic cholangiocarcinoma still has a dismal prognosis. The aim of our study was to investigate the prognostic role of bone metastases in patients affected by intrahepatic cholangiocarcinoma. Methods: A total of 186 metastatic intrahepatic cholangiocarcinoma patients wer...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/30/3/199 |
| _version_ | 1827750370558869504 |
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| author | Ingrid Garajová Fabio Gelsomino Massimiliano Salati Francesco Leonardi Stefania De Lorenzo Alessandro Granito Francesco Tovoli |
| author_facet | Ingrid Garajová Fabio Gelsomino Massimiliano Salati Francesco Leonardi Stefania De Lorenzo Alessandro Granito Francesco Tovoli |
| author_sort | Ingrid Garajová |
| collection | DOAJ |
| description | Background: Metastatic intrahepatic cholangiocarcinoma still has a dismal prognosis. The aim of our study was to investigate the prognostic role of bone metastases in patients affected by intrahepatic cholangiocarcinoma. Methods: A total of 186 metastatic intrahepatic cholangiocarcinoma patients were retrospectively reviewed. Clinicopathologic and survival data were collected and reviewed, in particular overall survival, progression-free survival after first-line treatment and time from end of first-line therapy to cancer death. Results: Around 11% of intrahepatic cholangiocarcinoma patients developed bone metastases. This subgroup of patients showed no differences in progression-free survival to first-line chemotherapy but had a shorter median overall survival of 4 months compared to the group with liver involvement only (<i>p</i> = 0.03). If treated, the outcome for ECOG PS 2 patients with bone metastases was worse in comparison to patients with liver involvement only with poor performance status (<i>p</i> = 0.003). The presence of bone metastases, poor performance status and no subsequent second-line treatment was associated with a worse outcome in multivariate analysis. Conclusions: Patients with intrahepatic carcinoma and bone metastases with poor ECOG performance status might be treated with best supportive care and not active chemotherapy treatment, the decisions which have to be shared with patients. |
| first_indexed | 2024-03-11T06:41:38Z |
| format | Article |
| id | doaj.art-42cc963495e44deba82040c19b4d747f |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-11T06:41:38Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-42cc963495e44deba82040c19b4d747f2023-11-17T10:30:36ZengMDPI AGCurrent Oncology1198-00521718-77292023-02-013032613262410.3390/curroncol30030199Bone Metastases from Intrahepatic Cholangiocarcinoma Confer Worse PrognosisIngrid Garajová0Fabio Gelsomino1Massimiliano Salati2Francesco Leonardi3Stefania De Lorenzo4Alessandro Granito5Francesco Tovoli6Medical Oncology Unit, University Hospital of Parma, 43125 Parma, ItalyDepartment of Oncology and Hematology, University Hospital of Modena, 41124 Modena, ItalyDepartment of Oncology and Hematology, University Hospital of Modena, 41124 Modena, ItalyMedical Oncology Unit, University Hospital of Parma, 43125 Parma, ItalyOncology Unit, Azienda USL Bologna, 40139 Bologna, ItalyDivision of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyDivision of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyBackground: Metastatic intrahepatic cholangiocarcinoma still has a dismal prognosis. The aim of our study was to investigate the prognostic role of bone metastases in patients affected by intrahepatic cholangiocarcinoma. Methods: A total of 186 metastatic intrahepatic cholangiocarcinoma patients were retrospectively reviewed. Clinicopathologic and survival data were collected and reviewed, in particular overall survival, progression-free survival after first-line treatment and time from end of first-line therapy to cancer death. Results: Around 11% of intrahepatic cholangiocarcinoma patients developed bone metastases. This subgroup of patients showed no differences in progression-free survival to first-line chemotherapy but had a shorter median overall survival of 4 months compared to the group with liver involvement only (<i>p</i> = 0.03). If treated, the outcome for ECOG PS 2 patients with bone metastases was worse in comparison to patients with liver involvement only with poor performance status (<i>p</i> = 0.003). The presence of bone metastases, poor performance status and no subsequent second-line treatment was associated with a worse outcome in multivariate analysis. Conclusions: Patients with intrahepatic carcinoma and bone metastases with poor ECOG performance status might be treated with best supportive care and not active chemotherapy treatment, the decisions which have to be shared with patients.https://www.mdpi.com/1718-7729/30/3/199cholangiocarcinomaintrahepaticbone metastasesoutcomesurvival |
| spellingShingle | Ingrid Garajová Fabio Gelsomino Massimiliano Salati Francesco Leonardi Stefania De Lorenzo Alessandro Granito Francesco Tovoli Bone Metastases from Intrahepatic Cholangiocarcinoma Confer Worse Prognosis Current Oncology cholangiocarcinoma intrahepatic bone metastases outcome survival |
| title | Bone Metastases from Intrahepatic Cholangiocarcinoma Confer Worse Prognosis |
| title_full | Bone Metastases from Intrahepatic Cholangiocarcinoma Confer Worse Prognosis |
| title_fullStr | Bone Metastases from Intrahepatic Cholangiocarcinoma Confer Worse Prognosis |
| title_full_unstemmed | Bone Metastases from Intrahepatic Cholangiocarcinoma Confer Worse Prognosis |
| title_short | Bone Metastases from Intrahepatic Cholangiocarcinoma Confer Worse Prognosis |
| title_sort | bone metastases from intrahepatic cholangiocarcinoma confer worse prognosis |
| topic | cholangiocarcinoma intrahepatic bone metastases outcome survival |
| url | https://www.mdpi.com/1718-7729/30/3/199 |
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