Myocardial infarction and stem cells
Permanent loss of cardiomyocytes and scar tissue formation after myocardial infarction (MI) results in an irreversible damage to the cardiac function. Cardiac repair (replacement, restoration, and regeneration) is, therefore, essential to restore function of the heart following MI. Existing therapie...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2011;volume=3;issue=2;spage=182;epage=188;aulast=Krishna |
| _version_ | 1828857812536524800 |
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| author | K Ananda Krishna K Sai Krishna Ruben Berrocal K S Rao K. R. S. Sambasiva Rao |
| author_facet | K Ananda Krishna K Sai Krishna Ruben Berrocal K S Rao K. R. S. Sambasiva Rao |
| author_sort | K Ananda Krishna |
| collection | DOAJ |
| description | Permanent loss of cardiomyocytes and scar tissue formation after myocardial infarction (MI) results in an irreversible damage to the cardiac function. Cardiac repair (replacement, restoration, and regeneration) is, therefore, essential to restore function of the heart following MI. Existing therapies lower early mortality rates, prevent additional damage to the heart muscle, and reduce the risk of further heart attacks. However, there is need for treatment to improve the infarcted area by replacing the damaged cells after MI. Thus, the cardiac tissue regeneration with the application of stem cells may be an effective therapeutic option. Recently, interest is more inclined toward myocardial regeneration with the application of stem cells. However, the potential benefits and the ability to improve cardiac function with the stem cell-based therapy need to be further addressed. In this review, we focus on the clinical applications of stem cells in the cardiac repair. |
| first_indexed | 2024-12-13T01:44:15Z |
| format | Article |
| id | doaj.art-42cd0bf44a814044961fadc38b14f4a7 |
| institution | Directory Open Access Journal |
| issn | 0975-7406 0976-4879 |
| language | English |
| last_indexed | 2024-12-13T01:44:15Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj.art-42cd0bf44a814044961fadc38b14f4a72022-12-22T00:03:41ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74060976-48792011-01-013218218810.4103/0975-7406.80761Myocardial infarction and stem cellsK Ananda KrishnaK Sai KrishnaRuben BerrocalK S RaoK. R. S. Sambasiva RaoPermanent loss of cardiomyocytes and scar tissue formation after myocardial infarction (MI) results in an irreversible damage to the cardiac function. Cardiac repair (replacement, restoration, and regeneration) is, therefore, essential to restore function of the heart following MI. Existing therapies lower early mortality rates, prevent additional damage to the heart muscle, and reduce the risk of further heart attacks. However, there is need for treatment to improve the infarcted area by replacing the damaged cells after MI. Thus, the cardiac tissue regeneration with the application of stem cells may be an effective therapeutic option. Recently, interest is more inclined toward myocardial regeneration with the application of stem cells. However, the potential benefits and the ability to improve cardiac function with the stem cell-based therapy need to be further addressed. In this review, we focus on the clinical applications of stem cells in the cardiac repair.http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2011;volume=3;issue=2;spage=182;epage=188;aulast=KrishnaCardiomyocytesmyocardial infarctionstem cellsstem cell transplantation |
| spellingShingle | K Ananda Krishna K Sai Krishna Ruben Berrocal K S Rao K. R. S. Sambasiva Rao Myocardial infarction and stem cells Journal of Pharmacy and Bioallied Sciences Cardiomyocytes myocardial infarction stem cells stem cell transplantation |
| title | Myocardial infarction and stem cells |
| title_full | Myocardial infarction and stem cells |
| title_fullStr | Myocardial infarction and stem cells |
| title_full_unstemmed | Myocardial infarction and stem cells |
| title_short | Myocardial infarction and stem cells |
| title_sort | myocardial infarction and stem cells |
| topic | Cardiomyocytes myocardial infarction stem cells stem cell transplantation |
| url | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2011;volume=3;issue=2;spage=182;epage=188;aulast=Krishna |
| work_keys_str_mv | AT kanandakrishna myocardialinfarctionandstemcells AT ksaikrishna myocardialinfarctionandstemcells AT rubenberrocal myocardialinfarctionandstemcells AT ksrao myocardialinfarctionandstemcells AT krssambasivarao myocardialinfarctionandstemcells |