Simplified molecular classification of lung adenocarcinomas based on EGFR, KRAS, and TP53 mutations

Simplified molecular classification of lung adenocarcinomas based on EGFR, KRAS, and TP53 mutations

Abstract Background Gene expression profiling has consistently identified three molecular subtypes of lung adenocarcinoma that have prognostic implications. To facilitate stratification of patients with this disease into similar molecular subtypes, we developed and validated a simple, mutually exclu...

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Bibliographic Details
Main Authors: Roberto Ruiz-Cordero, Junsheng Ma, Abha Khanna, Genevieve Lyons, Waree Rinsurongkawong, Roland Bassett, Ming Guo, Mark J. Routbort, Jianjun Zhang, Ferdinandos Skoulidis, John Heymach, Emily B. Roarty, Zhenya Tang, L. Jeffrey Medeiros, Keyur P. Patel, Rajyalakshmi Luthra, Sinchita Roy-Chowdhuri
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Cancer
Subjects:
Lung adenocarcinoma
Next generation sequencing
Molecular subtypes
Online Access:https://doi.org/10.1186/s12885-020-6579-z

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