Allergy and immunology in young children of Japan: The JECS cohort
Background: Capturing epidemiological signatures is essential to document burdens of disease and to design health care services, including prevention measures, clinical interventions, and policies. There are large geographical and ethnic variations in the epidemiology of allergic and immunological d...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-11-01
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| Series: | World Allergy Organization Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455120303823 |
| _version_ | 1819052898896576512 |
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| author | Kiwako Yamamoto-Hanada Kyongsun Pak Mayako Saito-Abe Limin Yang Miori Sato Makoto Irahara Hidetoshi Mezawa Hatoko Sasaki Minaho Nishizato Kazue Ishitsuka Yukihiro Ohya Michihiro Kamijima Shin Yamazaki Yukihiro Ohya Reiko Kishi Nobuo Yaegashi Koichi Hashimoto Chisato Mori Shuichi Ito Zentaro Yamagata Hidekuni Inadera Takeo Nakayama Hiroyasu Iso Masayuki Shima Youichi Kurozawa Narufumi Suganuma Koichi Kusuhara Takahiko Katoh |
| author_facet | Kiwako Yamamoto-Hanada Kyongsun Pak Mayako Saito-Abe Limin Yang Miori Sato Makoto Irahara Hidetoshi Mezawa Hatoko Sasaki Minaho Nishizato Kazue Ishitsuka Yukihiro Ohya Michihiro Kamijima Shin Yamazaki Yukihiro Ohya Reiko Kishi Nobuo Yaegashi Koichi Hashimoto Chisato Mori Shuichi Ito Zentaro Yamagata Hidekuni Inadera Takeo Nakayama Hiroyasu Iso Masayuki Shima Youichi Kurozawa Narufumi Suganuma Koichi Kusuhara Takahiko Katoh |
| author_sort | Kiwako Yamamoto-Hanada |
| collection | DOAJ |
| description | Background: Capturing epidemiological signatures is essential to document burdens of disease and to design health care services, including prevention measures, clinical interventions, and policies. There are large geographical and ethnic variations in the epidemiology of allergic and immunological diseases. Various data are available from North America and Europe, but the epidemiology of allergic and immunological diseases in Asia is not well documented. Objective: To characterize epidemiological signatures of allergic and immunological disease in young children in Japan. Methods: This was a national, multicenter, prospective birth cohort study: Japan Environment and Children's Study (JECS). A general population of 103,060 women was enrolled during pregnancy. Allergic and immunological outcomes were assessed among young children using questionnaire data. Results: The prevalence of caregiver-reported immediate food allergy was 7.6%, 6.7%, and 4.9% at age 1, 2, and 3 years, respectively. Hen egg allergy was most common (5.4% prevalence at age 1 year) followed by allergies to cow milk and wheat. Several patterns of allergic symptom clusters were identified. Physician diagnosed, as reported by the caregiver, non-IgE mediated gastrointestinal food allergy affected 0.5% of infants. By contrast, caregiver-reported gastrointestinal food allergies affected 1.4% of children. Kawasaki disease affected 0.3% and 0.4% children, respectively, at age 1 and 3 years. Primary immunodeficiency disorders affected 0.005% children at age 3 years. Conclusion: These data provide important epidemiological signatures of allergy and immunology in young Japanese children including the age-specific prevalence of allergic disease, Kawasaki disease, and primary immune deficiency. |
| first_indexed | 2024-12-21T12:27:09Z |
| format | Article |
| id | doaj.art-42cf4d51209c43d9b1d0aef8a751dcea |
| institution | Directory Open Access Journal |
| issn | 1939-4551 |
| language | English |
| last_indexed | 2024-12-21T12:27:09Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj.art-42cf4d51209c43d9b1d0aef8a751dcea2022-12-21T19:04:08ZengElsevierWorld Allergy Organization Journal1939-45512020-11-011311100479Allergy and immunology in young children of Japan: The JECS cohortKiwako Yamamoto-Hanada0Kyongsun Pak1Mayako Saito-Abe2Limin Yang3Miori Sato4Makoto Irahara5Hidetoshi Mezawa6Hatoko Sasaki7Minaho Nishizato8Kazue Ishitsuka9Yukihiro Ohya10Michihiro KamijimaShin YamazakiYukihiro OhyaReiko KishiNobuo YaegashiKoichi HashimotoChisato MoriShuichi ItoZentaro YamagataHidekuni InaderaTakeo NakayamaHiroyasu IsoMasayuki ShimaYouichi KurozawaNarufumi SuganumaKoichi KusuharaTakahiko KatohAllergy Center, National Center for Child Health and Development, Tokyo, Japan; Medical Support Center for the Japan Environment and Children's Study, National Research Institute for Child Health and Development, Tokyo, Japan; Corresponding author. Allergy Center, Medical Support Center for Japan Environment and Children's Study (JECS), National Center for Child Health and Development, 2-10-1, Okura, Setagayaku, Tokyo, 157-8535, Japan,Division of Biostatistics, Department of Data Management, Center for Clinical Research and Development, National Center for Child Health and Development, Tokyo, JapanAllergy Center, National Center for Child Health and Development, Tokyo, Japan; Medical Support Center for the Japan Environment and Children's Study, National Research Institute for Child Health and Development, Tokyo, JapanAllergy Center, National Center for Child Health and Development, Tokyo, Japan; Medical Support Center for the Japan Environment and Children's Study, National Research Institute for Child Health and Development, Tokyo, JapanAllergy Center, National Center for Child Health and Development, Tokyo, Japan; Medical Support Center for the Japan Environment and Children's Study, National Research Institute for Child Health and Development, Tokyo, JapanAllergy Center, National Center for Child Health and Development, Tokyo, Japan; Medical Support Center for the Japan Environment and Children's Study, National Research Institute for Child Health and Development, Tokyo, JapanMedical Support Center for the Japan Environment and Children's Study, National Research Institute for Child Health and Development, Tokyo, JapanMedical Support Center for the Japan Environment and Children's Study, National Research Institute for Child Health and Development, Tokyo, JapanMedical Support Center for the Japan Environment and Children's Study, National Research Institute for Child Health and Development, Tokyo, JapanMedical Support Center for the Japan Environment and Children's Study, National Research Institute for Child Health and Development, Tokyo, JapanAllergy Center, National Center for Child Health and Development, Tokyo, Japan; Medical Support Center for the Japan Environment and Children's Study, National Research Institute for Child Health and Development, Tokyo, JapanBackground: Capturing epidemiological signatures is essential to document burdens of disease and to design health care services, including prevention measures, clinical interventions, and policies. There are large geographical and ethnic variations in the epidemiology of allergic and immunological diseases. Various data are available from North America and Europe, but the epidemiology of allergic and immunological diseases in Asia is not well documented. Objective: To characterize epidemiological signatures of allergic and immunological disease in young children in Japan. Methods: This was a national, multicenter, prospective birth cohort study: Japan Environment and Children's Study (JECS). A general population of 103,060 women was enrolled during pregnancy. Allergic and immunological outcomes were assessed among young children using questionnaire data. Results: The prevalence of caregiver-reported immediate food allergy was 7.6%, 6.7%, and 4.9% at age 1, 2, and 3 years, respectively. Hen egg allergy was most common (5.4% prevalence at age 1 year) followed by allergies to cow milk and wheat. Several patterns of allergic symptom clusters were identified. Physician diagnosed, as reported by the caregiver, non-IgE mediated gastrointestinal food allergy affected 0.5% of infants. By contrast, caregiver-reported gastrointestinal food allergies affected 1.4% of children. Kawasaki disease affected 0.3% and 0.4% children, respectively, at age 1 and 3 years. Primary immunodeficiency disorders affected 0.005% children at age 3 years. Conclusion: These data provide important epidemiological signatures of allergy and immunology in young Japanese children including the age-specific prevalence of allergic disease, Kawasaki disease, and primary immune deficiency.http://www.sciencedirect.com/science/article/pii/S1939455120303823AsthmaAtopic dermatitisAtopic marchChildrenEczemaEpidemiology |
| spellingShingle | Kiwako Yamamoto-Hanada Kyongsun Pak Mayako Saito-Abe Limin Yang Miori Sato Makoto Irahara Hidetoshi Mezawa Hatoko Sasaki Minaho Nishizato Kazue Ishitsuka Yukihiro Ohya Michihiro Kamijima Shin Yamazaki Yukihiro Ohya Reiko Kishi Nobuo Yaegashi Koichi Hashimoto Chisato Mori Shuichi Ito Zentaro Yamagata Hidekuni Inadera Takeo Nakayama Hiroyasu Iso Masayuki Shima Youichi Kurozawa Narufumi Suganuma Koichi Kusuhara Takahiko Katoh Allergy and immunology in young children of Japan: The JECS cohort World Allergy Organization Journal Asthma Atopic dermatitis Atopic march Children Eczema Epidemiology |
| title | Allergy and immunology in young children of Japan: The JECS cohort |
| title_full | Allergy and immunology in young children of Japan: The JECS cohort |
| title_fullStr | Allergy and immunology in young children of Japan: The JECS cohort |
| title_full_unstemmed | Allergy and immunology in young children of Japan: The JECS cohort |
| title_short | Allergy and immunology in young children of Japan: The JECS cohort |
| title_sort | allergy and immunology in young children of japan the jecs cohort |
| topic | Asthma Atopic dermatitis Atopic march Children Eczema Epidemiology |
| url | http://www.sciencedirect.com/science/article/pii/S1939455120303823 |
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