Exposure to Benzo[a]pyrene and 1-Nitropyrene in Particulate Matter Increases Oxidative Stress in the Human Body
Polycyclic aromatic hydrocarbons (PAHs) have been reported to cause oxidative stress in metabolic processes. This study aimed to evaluate the relationship between exposure to PAHs, including benzo[a]pyrene (BaP) and 1-nitropyrene (1-NP), in the atmosphere and oxidative stress levels in the human bod...
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MDPI AG
2023-09-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/11/9/797 |
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| author | Sun-Haeng Choi Bolormaa Ochirpurev Akira Toriba Jong-Uk Won Heon Kim |
| author_facet | Sun-Haeng Choi Bolormaa Ochirpurev Akira Toriba Jong-Uk Won Heon Kim |
| author_sort | Sun-Haeng Choi |
| collection | DOAJ |
| description | Polycyclic aromatic hydrocarbons (PAHs) have been reported to cause oxidative stress in metabolic processes. This study aimed to evaluate the relationship between exposure to PAHs, including benzo[a]pyrene (BaP) and 1-nitropyrene (1-NP), in the atmosphere and oxidative stress levels in the human body. This study included 44 Korean adults who lived in Cheongju, Republic of Korea. Atmospheric BaP and 1-NP concentrations and urinary 6-hydroxy-1-nitropyrene (6-OHNP), N-acetyl-1-aminopyrene (1-NAAP), and 1-hydroxypyrene (1-OHP) concentrations were measured. The oxidative stress level was assessed by measuring urinary thiobarbituric acid-reactive substances (TBARS) and 8-hydroxydeoxyguanosine (8-OHdG) concentrations. Urinary TBARS and 6-OHNP concentrations significantly differed between winter and summer. BaP exposure was significantly associated with urinary 8-OHdG concentrations in summer. However, atmospheric 1-NP did not show a significant correlation with oxidative stress marker concentrations. Urinary 1-NAAP concentration was a significant determinant for urinary 8-OHdG concentration in summer. Oxidative stress in the body increases in proportion to inhalation exposure to BaP, and more 8-OHdG is produced in the body as the amount of 1-NP, which is metabolized to 1-AP or 1-NAAP, increases. |
| first_indexed | 2024-03-10T21:53:28Z |
| format | Article |
| id | doaj.art-42d034e0d95b4d94a2e402251356c937 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-10T21:53:28Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-42d034e0d95b4d94a2e402251356c9372023-11-19T13:15:19ZengMDPI AGToxics2305-63042023-09-0111979710.3390/toxics11090797Exposure to Benzo[a]pyrene and 1-Nitropyrene in Particulate Matter Increases Oxidative Stress in the Human BodySun-Haeng Choi0Bolormaa Ochirpurev1Akira Toriba2Jong-Uk Won3Heon Kim4Department of Occupational and Environmental Medicine, Chungbuk National University Hospital, Cheongju 28644, Republic of KoreaDepartment of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju 28644, Republic of KoreaDepartment of Hygienic Chemistry, Graduate School of Biomedical Science, Nagasaki University, Nagasaki 852-8521, JapanDepartment of Public Health, Graduate School, Yonsei University, Seoul 03722, Republic of KoreaDepartment of Occupational and Environmental Medicine, Chungbuk National University Hospital, Cheongju 28644, Republic of KoreaPolycyclic aromatic hydrocarbons (PAHs) have been reported to cause oxidative stress in metabolic processes. This study aimed to evaluate the relationship between exposure to PAHs, including benzo[a]pyrene (BaP) and 1-nitropyrene (1-NP), in the atmosphere and oxidative stress levels in the human body. This study included 44 Korean adults who lived in Cheongju, Republic of Korea. Atmospheric BaP and 1-NP concentrations and urinary 6-hydroxy-1-nitropyrene (6-OHNP), N-acetyl-1-aminopyrene (1-NAAP), and 1-hydroxypyrene (1-OHP) concentrations were measured. The oxidative stress level was assessed by measuring urinary thiobarbituric acid-reactive substances (TBARS) and 8-hydroxydeoxyguanosine (8-OHdG) concentrations. Urinary TBARS and 6-OHNP concentrations significantly differed between winter and summer. BaP exposure was significantly associated with urinary 8-OHdG concentrations in summer. However, atmospheric 1-NP did not show a significant correlation with oxidative stress marker concentrations. Urinary 1-NAAP concentration was a significant determinant for urinary 8-OHdG concentration in summer. Oxidative stress in the body increases in proportion to inhalation exposure to BaP, and more 8-OHdG is produced in the body as the amount of 1-NP, which is metabolized to 1-AP or 1-NAAP, increases.https://www.mdpi.com/2305-6304/11/9/797polycyclic aromatic hydrocarbonsbenzo[a]pyrene1-nitropyreneoxidative stressthiobarbituric acid-reactive substances8-hydroxydeoxyguanosine |
| spellingShingle | Sun-Haeng Choi Bolormaa Ochirpurev Akira Toriba Jong-Uk Won Heon Kim Exposure to Benzo[a]pyrene and 1-Nitropyrene in Particulate Matter Increases Oxidative Stress in the Human Body Toxics polycyclic aromatic hydrocarbons benzo[a]pyrene 1-nitropyrene oxidative stress thiobarbituric acid-reactive substances 8-hydroxydeoxyguanosine |
| title | Exposure to Benzo[a]pyrene and 1-Nitropyrene in Particulate Matter Increases Oxidative Stress in the Human Body |
| title_full | Exposure to Benzo[a]pyrene and 1-Nitropyrene in Particulate Matter Increases Oxidative Stress in the Human Body |
| title_fullStr | Exposure to Benzo[a]pyrene and 1-Nitropyrene in Particulate Matter Increases Oxidative Stress in the Human Body |
| title_full_unstemmed | Exposure to Benzo[a]pyrene and 1-Nitropyrene in Particulate Matter Increases Oxidative Stress in the Human Body |
| title_short | Exposure to Benzo[a]pyrene and 1-Nitropyrene in Particulate Matter Increases Oxidative Stress in the Human Body |
| title_sort | exposure to benzo a pyrene and 1 nitropyrene in particulate matter increases oxidative stress in the human body |
| topic | polycyclic aromatic hydrocarbons benzo[a]pyrene 1-nitropyrene oxidative stress thiobarbituric acid-reactive substances 8-hydroxydeoxyguanosine |
| url | https://www.mdpi.com/2305-6304/11/9/797 |
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