Enhancer Function in the 3D Genome
In this review, we consider various aspects of enhancer functioning in the context of the 3D genome. Particular attention is paid to the mechanisms of enhancer-promoter communication and the significance of the spatial juxtaposition of enhancers and promoters in 3D nuclear space. A model of an activ...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-06-01
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| Series: | Genes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4425/14/6/1277 |
| _version_ | 1797594644924596224 |
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| author | Sergey V. Razin Sergey V. Ulianov Olga V. Iarovaia |
| author_facet | Sergey V. Razin Sergey V. Ulianov Olga V. Iarovaia |
| author_sort | Sergey V. Razin |
| collection | DOAJ |
| description | In this review, we consider various aspects of enhancer functioning in the context of the 3D genome. Particular attention is paid to the mechanisms of enhancer-promoter communication and the significance of the spatial juxtaposition of enhancers and promoters in 3D nuclear space. A model of an activator chromatin compartment is substantiated, which provides the possibility of transferring activating factors from an enhancer to a promoter without establishing direct contact between these elements. The mechanisms of selective activation of individual promoters or promoter classes by enhancers are also discussed. |
| first_indexed | 2024-03-11T02:25:14Z |
| format | Article |
| id | doaj.art-42d41562ca9a4c5eaf20516cc9685fce |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-11T02:25:14Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-42d41562ca9a4c5eaf20516cc9685fce2023-11-18T10:35:15ZengMDPI AGGenes2073-44252023-06-01146127710.3390/genes14061277Enhancer Function in the 3D GenomeSergey V. Razin0Sergey V. Ulianov1Olga V. Iarovaia2Institute of Gene Biology Russian Academy of Sciences, 119334 Moscow, RussiaInstitute of Gene Biology Russian Academy of Sciences, 119334 Moscow, RussiaInstitute of Gene Biology Russian Academy of Sciences, 119334 Moscow, RussiaIn this review, we consider various aspects of enhancer functioning in the context of the 3D genome. Particular attention is paid to the mechanisms of enhancer-promoter communication and the significance of the spatial juxtaposition of enhancers and promoters in 3D nuclear space. A model of an activator chromatin compartment is substantiated, which provides the possibility of transferring activating factors from an enhancer to a promoter without establishing direct contact between these elements. The mechanisms of selective activation of individual promoters or promoter classes by enhancers are also discussed.https://www.mdpi.com/2073-4425/14/6/1277enhancer-promoter communication3D genomechromatin compartmentphase separation |
| spellingShingle | Sergey V. Razin Sergey V. Ulianov Olga V. Iarovaia Enhancer Function in the 3D Genome Genes enhancer-promoter communication 3D genome chromatin compartment phase separation |
| title | Enhancer Function in the 3D Genome |
| title_full | Enhancer Function in the 3D Genome |
| title_fullStr | Enhancer Function in the 3D Genome |
| title_full_unstemmed | Enhancer Function in the 3D Genome |
| title_short | Enhancer Function in the 3D Genome |
| title_sort | enhancer function in the 3d genome |
| topic | enhancer-promoter communication 3D genome chromatin compartment phase separation |
| url | https://www.mdpi.com/2073-4425/14/6/1277 |
| work_keys_str_mv | AT sergeyvrazin enhancerfunctioninthe3dgenome AT sergeyvulianov enhancerfunctioninthe3dgenome AT olgaviarovaia enhancerfunctioninthe3dgenome |