Arterial stiffness can occur early in mild-to-moderate chronic obstructive pulmonary disease
Abstract Background Chronic obstructive pulmonary disease (COPD) is a well-known respiratory system disorder impacting patient’s morbidity and mortality. Many COPD patients die from cardiovascular diseases. Criteria of arterial stiffness might be the early clue for cardiovascular affection in COPD p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-07-01
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| Series: | The Egyptian Journal of Bronchology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s43168-020-00014-1 |
| _version_ | 1818495963458699264 |
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| author | Waleed Mansour Mohamed El-Shabrawy Wael A. Khalil Ahmad S. Eldamanhory Sameh Embarak |
| author_facet | Waleed Mansour Mohamed El-Shabrawy Wael A. Khalil Ahmad S. Eldamanhory Sameh Embarak |
| author_sort | Waleed Mansour |
| collection | DOAJ |
| description | Abstract Background Chronic obstructive pulmonary disease (COPD) is a well-known respiratory system disorder impacting patient’s morbidity and mortality. Many COPD patients die from cardiovascular diseases. Criteria of arterial stiffness might be the early clue for cardiovascular affection in COPD patients. This study aimed to evaluate the occurrence of arterial stiffness as an early subclinical change in stable mild to moderate COPD patients. Results This cross-sectional study included 80 mild-to-moderate COPD patients and another 80 healthy controls. The carotid-femoral pulse wave velocity (cf-PWV) and the heart rate adjusted augmentation index (AIx75) were statistically significantly higher (13.8 ± 2.6 and 23.9 ± 10.8, respectively) among studied mild-to-moderate COPD patients when compared to healthy controls (10.7 ± 1.1 and 18.1 ± 8.9, respectively) (p < 0.001). FEV1 (forced expiratory volume in 1 s) % of predicted correlated negatively with both AIx75 (r = − 0.84, p < 0.001) and cf-PWV (r = − 0.85, p < 0.001), while BODE (body mass index, airflow obstruction, dyspnea, and exercise capacity) index correlated positively with both AIx75 (r = 0.58, p < 0.001) and cf-PWV (r = 0.52, p < 0.001) in patients with mild-to-moderate COPD. Conclusions Pulse wave velocity and augmentation index correlated with FEV1% of predicted and BODE index in patients with mild-to-moderate COPD. |
| first_indexed | 2024-12-10T18:27:26Z |
| format | Article |
| id | doaj.art-42d525926264495495f504d59af4198f |
| institution | Directory Open Access Journal |
| issn | 2314-8551 |
| language | English |
| last_indexed | 2024-12-10T18:27:26Z |
| publishDate | 2020-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Bronchology |
| spelling | doaj.art-42d525926264495495f504d59af4198f2022-12-22T01:38:02ZengSpringerOpenThe Egyptian Journal of Bronchology2314-85512020-07-011411610.1186/s43168-020-00014-1Arterial stiffness can occur early in mild-to-moderate chronic obstructive pulmonary diseaseWaleed Mansour0Mohamed El-Shabrawy1Wael A. Khalil2Ahmad S. Eldamanhory3Sameh Embarak4Pulmonary Medicine Department, Zagazig Faculty of MedicinePulmonary Medicine Department, Zagazig Faculty of MedicineCardiology Department, Zagazig Faculty of MedicineCardiology Department, Zagazig Faculty of MedicinePulmonary Medicine Department, Zagazig Faculty of MedicineAbstract Background Chronic obstructive pulmonary disease (COPD) is a well-known respiratory system disorder impacting patient’s morbidity and mortality. Many COPD patients die from cardiovascular diseases. Criteria of arterial stiffness might be the early clue for cardiovascular affection in COPD patients. This study aimed to evaluate the occurrence of arterial stiffness as an early subclinical change in stable mild to moderate COPD patients. Results This cross-sectional study included 80 mild-to-moderate COPD patients and another 80 healthy controls. The carotid-femoral pulse wave velocity (cf-PWV) and the heart rate adjusted augmentation index (AIx75) were statistically significantly higher (13.8 ± 2.6 and 23.9 ± 10.8, respectively) among studied mild-to-moderate COPD patients when compared to healthy controls (10.7 ± 1.1 and 18.1 ± 8.9, respectively) (p < 0.001). FEV1 (forced expiratory volume in 1 s) % of predicted correlated negatively with both AIx75 (r = − 0.84, p < 0.001) and cf-PWV (r = − 0.85, p < 0.001), while BODE (body mass index, airflow obstruction, dyspnea, and exercise capacity) index correlated positively with both AIx75 (r = 0.58, p < 0.001) and cf-PWV (r = 0.52, p < 0.001) in patients with mild-to-moderate COPD. Conclusions Pulse wave velocity and augmentation index correlated with FEV1% of predicted and BODE index in patients with mild-to-moderate COPD.http://link.springer.com/article/10.1186/s43168-020-00014-1Arterial stiffnessCOPDPulse wave velocityAugmentation indexBODE index |
| spellingShingle | Waleed Mansour Mohamed El-Shabrawy Wael A. Khalil Ahmad S. Eldamanhory Sameh Embarak Arterial stiffness can occur early in mild-to-moderate chronic obstructive pulmonary disease The Egyptian Journal of Bronchology Arterial stiffness COPD Pulse wave velocity Augmentation index BODE index |
| title | Arterial stiffness can occur early in mild-to-moderate chronic obstructive pulmonary disease |
| title_full | Arterial stiffness can occur early in mild-to-moderate chronic obstructive pulmonary disease |
| title_fullStr | Arterial stiffness can occur early in mild-to-moderate chronic obstructive pulmonary disease |
| title_full_unstemmed | Arterial stiffness can occur early in mild-to-moderate chronic obstructive pulmonary disease |
| title_short | Arterial stiffness can occur early in mild-to-moderate chronic obstructive pulmonary disease |
| title_sort | arterial stiffness can occur early in mild to moderate chronic obstructive pulmonary disease |
| topic | Arterial stiffness COPD Pulse wave velocity Augmentation index BODE index |
| url | http://link.springer.com/article/10.1186/s43168-020-00014-1 |
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