Analyzing the genes related to nicotine addiction or schizophrenia via a pathway and network based approach
Abstract The prevalence of tobacco use in people with schizophrenia is much higher than in general population, which indicates a close relationship between nicotine addiction and schizophrenia. However, the molecular mechanism underlying the high comorbidity of tobacco smoking and schizophrenia rema...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-018-21297-x |
| _version_ | 1818996530241077248 |
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| author | Ying Hu Zhonghai Fang Yichen Yang Dekai Rohlsen-Neal Feng Cheng Ju Wang |
| author_facet | Ying Hu Zhonghai Fang Yichen Yang Dekai Rohlsen-Neal Feng Cheng Ju Wang |
| author_sort | Ying Hu |
| collection | DOAJ |
| description | Abstract The prevalence of tobacco use in people with schizophrenia is much higher than in general population, which indicates a close relationship between nicotine addiction and schizophrenia. However, the molecular mechanism underlying the high comorbidity of tobacco smoking and schizophrenia remains largely unclear. In this study, we conducted a pathway and network analysis on the genes potentially associated with nicotine addiction or schizophrenia to reveal the functional feature of these genes and their interactions. Of the 276 genes associated with nicotine addiction and 331 genes associated with schizophrenia, 52 genes were shared. From these genes, 12 significantly enriched pathways associated with both diseases were identified. These pathways included those related to synapse function and signaling transduction, and drug addiction. Further, we constructed a nicotine addiction-specific and schizophrenia-specific sub-network, identifying 11 novel candidate genes potentially associated with the two diseases. Finally, we built a schematic molecular network for nicotine addiction and schizophrenia based on the results of pathway and network analysis, providing a systematic view to understand the relationship between these two disorders. Our results illustrated that the biological processes underlying the comorbidity of nicotine addiction and schizophrenia was complex, and was likely induced by the dysfunction of multiple molecules and pathways. |
| first_indexed | 2024-12-20T21:31:12Z |
| format | Article |
| id | doaj.art-42d55e56da31487ab5bc0900492409cb |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T21:31:12Z |
| publishDate | 2018-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-42d55e56da31487ab5bc0900492409cb2022-12-21T19:26:02ZengNature PortfolioScientific Reports2045-23222018-02-018111010.1038/s41598-018-21297-xAnalyzing the genes related to nicotine addiction or schizophrenia via a pathway and network based approachYing Hu0Zhonghai Fang1Yichen Yang2Dekai Rohlsen-Neal3Feng Cheng4Ju Wang5School of Biomedical Engineering, Tianjin Medical UniversitySchool of Biomedical Engineering, Tianjin Medical UniversitySchool of Biomedical Engineering, Tianjin Medical UniversityDepartment of Pharmaceutical Science, College of Pharmacy, University of South FloridaDepartment of Pharmaceutical Science, College of Pharmacy, University of South FloridaSchool of Biomedical Engineering, Tianjin Medical UniversityAbstract The prevalence of tobacco use in people with schizophrenia is much higher than in general population, which indicates a close relationship between nicotine addiction and schizophrenia. However, the molecular mechanism underlying the high comorbidity of tobacco smoking and schizophrenia remains largely unclear. In this study, we conducted a pathway and network analysis on the genes potentially associated with nicotine addiction or schizophrenia to reveal the functional feature of these genes and their interactions. Of the 276 genes associated with nicotine addiction and 331 genes associated with schizophrenia, 52 genes were shared. From these genes, 12 significantly enriched pathways associated with both diseases were identified. These pathways included those related to synapse function and signaling transduction, and drug addiction. Further, we constructed a nicotine addiction-specific and schizophrenia-specific sub-network, identifying 11 novel candidate genes potentially associated with the two diseases. Finally, we built a schematic molecular network for nicotine addiction and schizophrenia based on the results of pathway and network analysis, providing a systematic view to understand the relationship between these two disorders. Our results illustrated that the biological processes underlying the comorbidity of nicotine addiction and schizophrenia was complex, and was likely induced by the dysfunction of multiple molecules and pathways.https://doi.org/10.1038/s41598-018-21297-x |
| spellingShingle | Ying Hu Zhonghai Fang Yichen Yang Dekai Rohlsen-Neal Feng Cheng Ju Wang Analyzing the genes related to nicotine addiction or schizophrenia via a pathway and network based approach Scientific Reports |
| title | Analyzing the genes related to nicotine addiction or schizophrenia via a pathway and network based approach |
| title_full | Analyzing the genes related to nicotine addiction or schizophrenia via a pathway and network based approach |
| title_fullStr | Analyzing the genes related to nicotine addiction or schizophrenia via a pathway and network based approach |
| title_full_unstemmed | Analyzing the genes related to nicotine addiction or schizophrenia via a pathway and network based approach |
| title_short | Analyzing the genes related to nicotine addiction or schizophrenia via a pathway and network based approach |
| title_sort | analyzing the genes related to nicotine addiction or schizophrenia via a pathway and network based approach |
| url | https://doi.org/10.1038/s41598-018-21297-x |
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