Non-Enzymatic Glucose Detection Based on NiS Nanoclusters@NiS Nanosphere in Human Serum and Urine
Herein, we report a non-enzymatic electrochemical glucose sensing platform based on NiS nanoclusters dispersed on NiS nanosphere (NC-NiS@NS-NiS) in human serum and urine samples. The NC-NiS@NS-NiS are directly grown on nickel foam (NF) (NC-NiS@NS-NiS|NF) substrate by a facile, and one-step electrode...
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| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/12/4/403 |
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| author | Mani Arivazhagan Yesupatham Manova Santhosh Govindhan Maduraiveeran |
| author_facet | Mani Arivazhagan Yesupatham Manova Santhosh Govindhan Maduraiveeran |
| author_sort | Mani Arivazhagan |
| collection | DOAJ |
| description | Herein, we report a non-enzymatic electrochemical glucose sensing platform based on NiS nanoclusters dispersed on NiS nanosphere (NC-NiS@NS-NiS) in human serum and urine samples. The NC-NiS@NS-NiS are directly grown on nickel foam (NF) (NC-NiS@NS-NiS|NF) substrate by a facile, and one-step electrodeposition strategy under acidic solution. The as-developed nanostructured NC-NiS@NS-NiS|NF electrode materials successfully employ as the enzyme-mimic electrocatalysts toward the improved electrocatalytic glucose oxidation and sensitive glucose sensing. The NC-NiS@NS-NiS|NF electrode presents an outstanding electrocatalytic activity and sensing capability towards the glucose owing to the attribution of great double layer capacitance, excessive electrochemical active surface area (ECASA), and high electrochemical active sites. The present sensor delivers a limit of detection (LOD) of ~0.0083 µM with a high sensitivity of 54.6 µA mM<sup>−1</sup> cm<sup>−2</sup> and a wide linear concentration range (20.0 µM–5.0 mM). The NC-NiS@NS-NiS|NF-based sensor demonstrates the good selectivity against the potential interferences and shows high practicability by glucose sensing in human urine and serum samples. |
| first_indexed | 2024-03-10T12:35:36Z |
| format | Article |
| id | doaj.art-42d9782a1d694f1aae6d2700f9260ef9 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T12:35:36Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-42d9782a1d694f1aae6d2700f9260ef92023-11-21T14:17:26ZengMDPI AGMicromachines2072-666X2021-04-0112440310.3390/mi12040403Non-Enzymatic Glucose Detection Based on NiS Nanoclusters@NiS Nanosphere in Human Serum and UrineMani Arivazhagan0Yesupatham Manova Santhosh1Govindhan Maduraiveeran2Materials Electrochemistry Laboratory, Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, IndiaMaterials Electrochemistry Laboratory, Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, IndiaMaterials Electrochemistry Laboratory, Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, IndiaHerein, we report a non-enzymatic electrochemical glucose sensing platform based on NiS nanoclusters dispersed on NiS nanosphere (NC-NiS@NS-NiS) in human serum and urine samples. The NC-NiS@NS-NiS are directly grown on nickel foam (NF) (NC-NiS@NS-NiS|NF) substrate by a facile, and one-step electrodeposition strategy under acidic solution. The as-developed nanostructured NC-NiS@NS-NiS|NF electrode materials successfully employ as the enzyme-mimic electrocatalysts toward the improved electrocatalytic glucose oxidation and sensitive glucose sensing. The NC-NiS@NS-NiS|NF electrode presents an outstanding electrocatalytic activity and sensing capability towards the glucose owing to the attribution of great double layer capacitance, excessive electrochemical active surface area (ECASA), and high electrochemical active sites. The present sensor delivers a limit of detection (LOD) of ~0.0083 µM with a high sensitivity of 54.6 µA mM<sup>−1</sup> cm<sup>−2</sup> and a wide linear concentration range (20.0 µM–5.0 mM). The NC-NiS@NS-NiS|NF-based sensor demonstrates the good selectivity against the potential interferences and shows high practicability by glucose sensing in human urine and serum samples.https://www.mdpi.com/2072-666X/12/4/403NiS nanomaterialschemically modified electrodeelectrochemical depositionelectrocatalytic oxidationglucose sensorbiomedical applications |
| spellingShingle | Mani Arivazhagan Yesupatham Manova Santhosh Govindhan Maduraiveeran Non-Enzymatic Glucose Detection Based on NiS Nanoclusters@NiS Nanosphere in Human Serum and Urine Micromachines NiS nanomaterials chemically modified electrode electrochemical deposition electrocatalytic oxidation glucose sensor biomedical applications |
| title | Non-Enzymatic Glucose Detection Based on NiS Nanoclusters@NiS Nanosphere in Human Serum and Urine |
| title_full | Non-Enzymatic Glucose Detection Based on NiS Nanoclusters@NiS Nanosphere in Human Serum and Urine |
| title_fullStr | Non-Enzymatic Glucose Detection Based on NiS Nanoclusters@NiS Nanosphere in Human Serum and Urine |
| title_full_unstemmed | Non-Enzymatic Glucose Detection Based on NiS Nanoclusters@NiS Nanosphere in Human Serum and Urine |
| title_short | Non-Enzymatic Glucose Detection Based on NiS Nanoclusters@NiS Nanosphere in Human Serum and Urine |
| title_sort | non enzymatic glucose detection based on nis nanoclusters nis nanosphere in human serum and urine |
| topic | NiS nanomaterials chemically modified electrode electrochemical deposition electrocatalytic oxidation glucose sensor biomedical applications |
| url | https://www.mdpi.com/2072-666X/12/4/403 |
| work_keys_str_mv | AT maniarivazhagan nonenzymaticglucosedetectionbasedonnisnanoclustersnisnanosphereinhumanserumandurine AT yesupathammanovasanthosh nonenzymaticglucosedetectionbasedonnisnanoclustersnisnanosphereinhumanserumandurine AT govindhanmaduraiveeran nonenzymaticglucosedetectionbasedonnisnanoclustersnisnanosphereinhumanserumandurine |