The role of the purinergic P2X<sub>7 </sub>receptor in inflammation
<p>Abstract</p> <p>The inflammatory process, orchestrated against a variety of injurious stimuli, is composed of three inter-related phases; initiation, propagation and resolution. Understanding the interplay between these three phases and harnessing the beneficial properties of in...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2007-03-01
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| Series: | Journal of Inflammation |
| Online Access: | http://www.journal-inflammation.com/content/4/1/5 |
| _version_ | 1818757248054198272 |
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| author | Rossi Adriano G Davidson Donald J Hodgkiss Joseph P Sawatzky Deborah A Sharkey John Lister Martin F Finlayson Keith |
| author_facet | Rossi Adriano G Davidson Donald J Hodgkiss Joseph P Sawatzky Deborah A Sharkey John Lister Martin F Finlayson Keith |
| author_sort | Rossi Adriano G |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The inflammatory process, orchestrated against a variety of injurious stimuli, is composed of three inter-related phases; initiation, propagation and resolution. Understanding the interplay between these three phases and harnessing the beneficial properties of inflammation whilst preventing its damaging effects, will undoubtedly lead to the advent of much needed therapies, particularly in chronic disease states. The P2X<sub>7 </sub>receptor (P2X<sub>7</sub>R) is increasingly recognised as an important cell surface regulator of several key inflammatory molecules including IL-1β, IL-18, TNF-α and IL-6. Moreover, as P2X<sub>7</sub>R-dependent cytokine production is driven by activating the inflammasome, antagonists of this receptor are likely to have therapeutic potential as novel anti-inflammatory therapies. The function of the P2X<sub>7</sub>R in inflammation, immunity and its potential role in disease will be reviewed and discussed.</p> |
| first_indexed | 2024-12-18T06:07:55Z |
| format | Article |
| id | doaj.art-42d9e9b5c1ee445a83ff7ed262944718 |
| institution | Directory Open Access Journal |
| issn | 1476-9255 |
| language | English |
| last_indexed | 2024-12-18T06:07:55Z |
| publishDate | 2007-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Inflammation |
| spelling | doaj.art-42d9e9b5c1ee445a83ff7ed2629447182022-12-21T21:18:29ZengBMCJournal of Inflammation1476-92552007-03-0141510.1186/1476-9255-4-5The role of the purinergic P2X<sub>7 </sub>receptor in inflammationRossi Adriano GDavidson Donald JHodgkiss Joseph PSawatzky Deborah ASharkey JohnLister Martin FFinlayson Keith<p>Abstract</p> <p>The inflammatory process, orchestrated against a variety of injurious stimuli, is composed of three inter-related phases; initiation, propagation and resolution. Understanding the interplay between these three phases and harnessing the beneficial properties of inflammation whilst preventing its damaging effects, will undoubtedly lead to the advent of much needed therapies, particularly in chronic disease states. The P2X<sub>7 </sub>receptor (P2X<sub>7</sub>R) is increasingly recognised as an important cell surface regulator of several key inflammatory molecules including IL-1β, IL-18, TNF-α and IL-6. Moreover, as P2X<sub>7</sub>R-dependent cytokine production is driven by activating the inflammasome, antagonists of this receptor are likely to have therapeutic potential as novel anti-inflammatory therapies. The function of the P2X<sub>7</sub>R in inflammation, immunity and its potential role in disease will be reviewed and discussed.</p>http://www.journal-inflammation.com/content/4/1/5 |
| spellingShingle | Rossi Adriano G Davidson Donald J Hodgkiss Joseph P Sawatzky Deborah A Sharkey John Lister Martin F Finlayson Keith The role of the purinergic P2X<sub>7 </sub>receptor in inflammation Journal of Inflammation |
| title | The role of the purinergic P2X<sub>7 </sub>receptor in inflammation |
| title_full | The role of the purinergic P2X<sub>7 </sub>receptor in inflammation |
| title_fullStr | The role of the purinergic P2X<sub>7 </sub>receptor in inflammation |
| title_full_unstemmed | The role of the purinergic P2X<sub>7 </sub>receptor in inflammation |
| title_short | The role of the purinergic P2X<sub>7 </sub>receptor in inflammation |
| title_sort | role of the purinergic p2x sub 7 sub receptor in inflammation |
| url | http://www.journal-inflammation.com/content/4/1/5 |
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