Role of Melatonin in Cancer: Effect on Clock Genes
The circadian clock is a regulatory system, with a periodicity of approximately 24 h, that generates rhythmic changes in many physiological processes. Increasing evidence links chronodisruption with aberrant functionality in clock gene expression, resulting in multiple diseases, including cancer. In...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/3/1919 |
| _version_ | 1797624462947909632 |
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| author | César Rodríguez-Santana Javier Florido Laura Martínez-Ruiz Alba López-Rodríguez Darío Acuña-Castroviejo Germaine Escames |
| author_facet | César Rodríguez-Santana Javier Florido Laura Martínez-Ruiz Alba López-Rodríguez Darío Acuña-Castroviejo Germaine Escames |
| author_sort | César Rodríguez-Santana |
| collection | DOAJ |
| description | The circadian clock is a regulatory system, with a periodicity of approximately 24 h, that generates rhythmic changes in many physiological processes. Increasing evidence links chronodisruption with aberrant functionality in clock gene expression, resulting in multiple diseases, including cancer. In this context, tumor cells have an altered circadian machinery compared to normal cells, which deregulates the cell cycle, repair mechanisms, energy metabolism and other processes. Melatonin is the main hormone produced by the pineal gland, whose production and secretion oscillates in accordance with the light:dark cycle. In addition, melatonin regulates the expression of clock genes, including those in cancer cells, which could play a key role in the numerous oncostatic effects of this hormone. This review aims to describe and clarify the role of clock genes in cancer, as well as the possible mechanisms of the action of melatonin through which it regulates the expression of the tumor’s circadian machinery, in order to propose future anti-neoplastic clinical treatments. |
| first_indexed | 2024-03-11T09:42:41Z |
| format | Article |
| id | doaj.art-42dc100c5b7b40ada01bb43246428e7d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:42:41Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-42dc100c5b7b40ada01bb43246428e7d2023-11-16T16:49:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01243191910.3390/ijms24031919Role of Melatonin in Cancer: Effect on Clock GenesCésar Rodríguez-Santana0Javier Florido1Laura Martínez-Ruiz2Alba López-Rodríguez3Darío Acuña-Castroviejo4Germaine Escames5Biomedical Research Center, Health Sciences Technology Park, University of Granada, 18016 Granada, SpainBiomedical Research Center, Health Sciences Technology Park, University of Granada, 18016 Granada, SpainBiomedical Research Center, Health Sciences Technology Park, University of Granada, 18016 Granada, SpainBiomedical Research Center, Health Sciences Technology Park, University of Granada, 18016 Granada, SpainBiomedical Research Center, Health Sciences Technology Park, University of Granada, 18016 Granada, SpainBiomedical Research Center, Health Sciences Technology Park, University of Granada, 18016 Granada, SpainThe circadian clock is a regulatory system, with a periodicity of approximately 24 h, that generates rhythmic changes in many physiological processes. Increasing evidence links chronodisruption with aberrant functionality in clock gene expression, resulting in multiple diseases, including cancer. In this context, tumor cells have an altered circadian machinery compared to normal cells, which deregulates the cell cycle, repair mechanisms, energy metabolism and other processes. Melatonin is the main hormone produced by the pineal gland, whose production and secretion oscillates in accordance with the light:dark cycle. In addition, melatonin regulates the expression of clock genes, including those in cancer cells, which could play a key role in the numerous oncostatic effects of this hormone. This review aims to describe and clarify the role of clock genes in cancer, as well as the possible mechanisms of the action of melatonin through which it regulates the expression of the tumor’s circadian machinery, in order to propose future anti-neoplastic clinical treatments.https://www.mdpi.com/1422-0067/24/3/1919melatonincancerclock genescircadian rhythmsSIRT1<i>c-Myc</i> |
| spellingShingle | César Rodríguez-Santana Javier Florido Laura Martínez-Ruiz Alba López-Rodríguez Darío Acuña-Castroviejo Germaine Escames Role of Melatonin in Cancer: Effect on Clock Genes International Journal of Molecular Sciences melatonin cancer clock genes circadian rhythms SIRT1 <i>c-Myc</i> |
| title | Role of Melatonin in Cancer: Effect on Clock Genes |
| title_full | Role of Melatonin in Cancer: Effect on Clock Genes |
| title_fullStr | Role of Melatonin in Cancer: Effect on Clock Genes |
| title_full_unstemmed | Role of Melatonin in Cancer: Effect on Clock Genes |
| title_short | Role of Melatonin in Cancer: Effect on Clock Genes |
| title_sort | role of melatonin in cancer effect on clock genes |
| topic | melatonin cancer clock genes circadian rhythms SIRT1 <i>c-Myc</i> |
| url | https://www.mdpi.com/1422-0067/24/3/1919 |
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