Meeting Challenges of Pediatric Drug Delivery: The Potential of Orally Fast Disintegrating Tablets for Infants and Children
A majority of therapeutics are not available as suitable dosage forms for administration to pediatric patients. The first part of this review provides an overview of clinical and technological challenges and opportunities in the development of child-friendly dosage forms such as taste masking, table...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/4/1033 |
| _version_ | 1797603870495473664 |
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| author | Klervi Golhen Michael Buettcher Jonas Kost Jörg Huwyler Marc Pfister |
| author_facet | Klervi Golhen Michael Buettcher Jonas Kost Jörg Huwyler Marc Pfister |
| author_sort | Klervi Golhen |
| collection | DOAJ |
| description | A majority of therapeutics are not available as suitable dosage forms for administration to pediatric patients. The first part of this review provides an overview of clinical and technological challenges and opportunities in the development of child-friendly dosage forms such as taste masking, tablet size, flexibility of dose administration, excipient safety and acceptability. In this context, developmental pharmacology, rapid onset of action in pediatric emergency situations, regulatory and socioeconomic aspects are also reviewed and illustrated with clinical case studies. The second part of this work discusses the example of Orally Dispersible Tablets (ODTs) as a child-friendly drug delivery strategy. Inorganic particulate drug carriers can thereby be used as multifunctional excipients offering a potential solution to address unique medical needs in infants and children while maintaining a favorable excipient safety and acceptability profile in these vulnerable patient populations. |
| first_indexed | 2024-03-11T04:38:07Z |
| format | Article |
| id | doaj.art-42dc62e20c2b4193b7670da3e8954c57 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T04:38:07Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-42dc62e20c2b4193b7670da3e8954c572023-11-17T20:51:45ZengMDPI AGPharmaceutics1999-49232023-03-01154103310.3390/pharmaceutics15041033Meeting Challenges of Pediatric Drug Delivery: The Potential of Orally Fast Disintegrating Tablets for Infants and ChildrenKlervi Golhen0Michael Buettcher1Jonas Kost2Jörg Huwyler3Marc Pfister4Pediatric Pharmacology and Pharmacometrics, University Children’s Hospital Basel (UKBB), University of Basel, 4056 Basel, SwitzerlandPediatric Pharmacology and Pharmacometrics, University Children’s Hospital Basel (UKBB), University of Basel, 4056 Basel, SwitzerlandDepartment of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel, 4056 Basel, SwitzerlandDepartment of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel, 4056 Basel, SwitzerlandPediatric Pharmacology and Pharmacometrics, University Children’s Hospital Basel (UKBB), University of Basel, 4056 Basel, SwitzerlandA majority of therapeutics are not available as suitable dosage forms for administration to pediatric patients. The first part of this review provides an overview of clinical and technological challenges and opportunities in the development of child-friendly dosage forms such as taste masking, tablet size, flexibility of dose administration, excipient safety and acceptability. In this context, developmental pharmacology, rapid onset of action in pediatric emergency situations, regulatory and socioeconomic aspects are also reviewed and illustrated with clinical case studies. The second part of this work discusses the example of Orally Dispersible Tablets (ODTs) as a child-friendly drug delivery strategy. Inorganic particulate drug carriers can thereby be used as multifunctional excipients offering a potential solution to address unique medical needs in infants and children while maintaining a favorable excipient safety and acceptability profile in these vulnerable patient populations.https://www.mdpi.com/1999-4923/15/4/1033patient safetychild-appropriate formulationsorally fast disintegrating tabletspediatricsformulationexcipient |
| spellingShingle | Klervi Golhen Michael Buettcher Jonas Kost Jörg Huwyler Marc Pfister Meeting Challenges of Pediatric Drug Delivery: The Potential of Orally Fast Disintegrating Tablets for Infants and Children Pharmaceutics patient safety child-appropriate formulations orally fast disintegrating tablets pediatrics formulation excipient |
| title | Meeting Challenges of Pediatric Drug Delivery: The Potential of Orally Fast Disintegrating Tablets for Infants and Children |
| title_full | Meeting Challenges of Pediatric Drug Delivery: The Potential of Orally Fast Disintegrating Tablets for Infants and Children |
| title_fullStr | Meeting Challenges of Pediatric Drug Delivery: The Potential of Orally Fast Disintegrating Tablets for Infants and Children |
| title_full_unstemmed | Meeting Challenges of Pediatric Drug Delivery: The Potential of Orally Fast Disintegrating Tablets for Infants and Children |
| title_short | Meeting Challenges of Pediatric Drug Delivery: The Potential of Orally Fast Disintegrating Tablets for Infants and Children |
| title_sort | meeting challenges of pediatric drug delivery the potential of orally fast disintegrating tablets for infants and children |
| topic | patient safety child-appropriate formulations orally fast disintegrating tablets pediatrics formulation excipient |
| url | https://www.mdpi.com/1999-4923/15/4/1033 |
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