| Summary: | During the course of our search for biologically active secondary metabolites from fungal cultures, a new oligocyclic diterpenoidal derivative, panapophenanthrin (<b>1</b>), was isolated from <i>Panus strigellus</i>. In addition, two known metabolites, panepophenanthrin (<b>2</b>) and dihydrohypnophilin (<b>3</b>), were also obtained. The chemical structures of the isolated compounds were elucidated based on extensive 1D and 2D NMR spectral analyses together with high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). The absolute configuration was determined through TDDFT-ECD calculations. All of the compounds were assessed for their antimicrobial and cytotoxic activities. Compounds <b>1</b> and <b>3</b> showed moderate to weak activities in the performed antimicrobial assays, while compound <b>1</b> exhibited potent cytotoxic activity against the mammalian cell lines mouse fibroblast (L929) and human endocervical adenocarcinoma (KB3.1).
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