Cell-autonomous mechanisms of chronological aging in the yeast Saccharomyces cerevisiae
A body of evidence supports the view that the signaling pathways governing cellular aging – as well as mechanisms of their modulation by longevity-extending genetic, dietary and pharmacological interventions - are conserved across species. The scope of this review is to critically analyze recent adv...
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2014-05-01
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| Series: | Microbial Cell |
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| Online Access: | http://microbialcell.com/researcharticles/cell-autonomous-mechanisms-of-chronological-aging-in-the-yeast-saccharomyces-cerevisiae-2/ |
| _version_ | 1811196694499426304 |
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| author | Anthony Arlia-Ciommo Anna Leonov Amanda Piano Veronika Svistkova Vladimir I. Titorenko |
| author_facet | Anthony Arlia-Ciommo Anna Leonov Amanda Piano Veronika Svistkova Vladimir I. Titorenko |
| author_sort | Anthony Arlia-Ciommo |
| collection | DOAJ |
| description | A body of evidence supports the view that the signaling pathways governing cellular aging – as well as mechanisms of their modulation by longevity-extending genetic, dietary and pharmacological interventions - are conserved across species. The scope of this review is to critically analyze recent advances in our understanding of cell-autonomous mechanisms of chronological aging in the budding yeast Saccharomyces cerevisiae. Based on our analysis, we propose a concept of a biomolecular network underlying the chronology of cellular aging in yeast. The concept posits that such network progresses through a series of lifespan checkpoints. At each of these checkpoints, the intracellular concentrations of some key intermediates and products of certain metabolic pathways - as well as the rates of coordinated flow of such metabolites within an intricate network of intercompartmental communications - are monitored by some checkpoint-specific ′′master regulator′′ proteins. The concept envisions that a synergistic action of these master regulator proteins at certain early-life and late-life checkpoints modulates the rates and efficiencies of progression of such processes as cell metabolism, growth, proliferation, stress resistance, macromolecular homeostasis, survival and death. The concept predicts that, by modulating these vital cellular processes throughout lifespan (i.e., prior to an arrest of cell growth and division, and following such arrest), the checkpoint-specific master regulator proteins orchestrate the development and maintenance of a pro- or anti-aging cellular pattern and, thus, define longevity of chronologically aging yeast. |
| first_indexed | 2024-04-12T01:03:17Z |
| format | Article |
| id | doaj.art-42ddc7c9125e4496b481ff257d64ebf2 |
| institution | Directory Open Access Journal |
| issn | 2311-2638 |
| language | English |
| last_indexed | 2024-04-12T01:03:17Z |
| publishDate | 2014-05-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj.art-42ddc7c9125e4496b481ff257d64ebf22022-12-22T03:54:21ZengShared Science Publishers OGMicrobial Cell2311-26382014-05-011616317810.15698/mic2014.06.152Cell-autonomous mechanisms of chronological aging in the yeast Saccharomyces cerevisiaeAnthony Arlia-Ciommo0Anna Leonov1Amanda Piano2Veronika Svistkova3Vladimir I. Titorenko4These authors contributed equally to this workThese authors contributed equally to this workThese authors contributed equally to this workThese authors contributed equally to this workDepartment of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.A body of evidence supports the view that the signaling pathways governing cellular aging – as well as mechanisms of their modulation by longevity-extending genetic, dietary and pharmacological interventions - are conserved across species. The scope of this review is to critically analyze recent advances in our understanding of cell-autonomous mechanisms of chronological aging in the budding yeast Saccharomyces cerevisiae. Based on our analysis, we propose a concept of a biomolecular network underlying the chronology of cellular aging in yeast. The concept posits that such network progresses through a series of lifespan checkpoints. At each of these checkpoints, the intracellular concentrations of some key intermediates and products of certain metabolic pathways - as well as the rates of coordinated flow of such metabolites within an intricate network of intercompartmental communications - are monitored by some checkpoint-specific ′′master regulator′′ proteins. The concept envisions that a synergistic action of these master regulator proteins at certain early-life and late-life checkpoints modulates the rates and efficiencies of progression of such processes as cell metabolism, growth, proliferation, stress resistance, macromolecular homeostasis, survival and death. The concept predicts that, by modulating these vital cellular processes throughout lifespan (i.e., prior to an arrest of cell growth and division, and following such arrest), the checkpoint-specific master regulator proteins orchestrate the development and maintenance of a pro- or anti-aging cellular pattern and, thus, define longevity of chronologically aging yeast.http://microbialcell.com/researcharticles/cell-autonomous-mechanisms-of-chronological-aging-in-the-yeast-saccharomyces-cerevisiae-2/yeast chronological agingsystems biology of cellular agingcell-autonomous mechanisms of longevity regulationproteostasislipid metabolismmitochondriacarbohydrate metabolism |
| spellingShingle | Anthony Arlia-Ciommo Anna Leonov Amanda Piano Veronika Svistkova Vladimir I. Titorenko Cell-autonomous mechanisms of chronological aging in the yeast Saccharomyces cerevisiae Microbial Cell yeast chronological aging systems biology of cellular aging cell-autonomous mechanisms of longevity regulation proteostasis lipid metabolism mitochondria carbohydrate metabolism |
| title | Cell-autonomous mechanisms of chronological aging in the yeast Saccharomyces cerevisiae |
| title_full | Cell-autonomous mechanisms of chronological aging in the yeast Saccharomyces cerevisiae |
| title_fullStr | Cell-autonomous mechanisms of chronological aging in the yeast Saccharomyces cerevisiae |
| title_full_unstemmed | Cell-autonomous mechanisms of chronological aging in the yeast Saccharomyces cerevisiae |
| title_short | Cell-autonomous mechanisms of chronological aging in the yeast Saccharomyces cerevisiae |
| title_sort | cell autonomous mechanisms of chronological aging in the yeast saccharomyces cerevisiae |
| topic | yeast chronological aging systems biology of cellular aging cell-autonomous mechanisms of longevity regulation proteostasis lipid metabolism mitochondria carbohydrate metabolism |
| url | http://microbialcell.com/researcharticles/cell-autonomous-mechanisms-of-chronological-aging-in-the-yeast-saccharomyces-cerevisiae-2/ |
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