Spontaneous remodeling of HDL particles at acidic pH enhances their capacity to induce cholesterol efflux from human macrophage foam cells

Spontaneous remodeling of HDL particles at acidic pH enhances their capacity to induce cholesterol efflux from human macrophage foam cells

HDL particles may enter atherosclerotic lesions having an acidic intimal fluid. Therefore, we investigated whether acidic pH would affect their structural and functional properties. For this purpose, HDL2 and HDL3 subfractions were incubated for various periods of time at different pH values ranging...

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Bibliographic Details
Main Authors: Su Duy Nguyen, Katariina Öörni, Miriam Lee-Rueckert, Tero Pihlajamaa, Jari Metso, Matti Jauhiainen, Petri T. Kovanen
Format: Article
Language:English
Published: Elsevier 2012-10-01
Series:Journal of Lipid Research
Subjects:
fusion
atherosclerosis
chymase
high density lipoprotein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520431888

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