TIF1 Proteins in Genome Stability and Cancer
Genomic instability is a hallmark of cancer cells which results in excessive DNA damage. To counteract this, cells have evolved a tightly regulated DNA damage response (DDR) to rapidly sense DNA damage and promote its repair whilst halting cell cycle progression. The DDR functions predominantly with...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-07-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/8/2094 |
| _version_ | 1797561055189139456 |
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| author | Roisin M. McAvera Lisa J. Crawford |
| author_facet | Roisin M. McAvera Lisa J. Crawford |
| author_sort | Roisin M. McAvera |
| collection | DOAJ |
| description | Genomic instability is a hallmark of cancer cells which results in excessive DNA damage. To counteract this, cells have evolved a tightly regulated DNA damage response (DDR) to rapidly sense DNA damage and promote its repair whilst halting cell cycle progression. The DDR functions predominantly within the context of chromatin and requires the action of chromatin-binding proteins to coordinate the appropriate response. TRIM24, TRIM28, TRIM33 and TRIM66 make up the transcriptional intermediary factor 1 (TIF1) family of chromatin-binding proteins, a subfamily of the large tripartite motif (TRIM) family of E3 ligases. All four TIF1 proteins are aberrantly expressed across numerous cancer types, and increasing evidence suggests that TIF1 family members can function to maintain genome stability by mediating chromatin-based responses to DNA damage. This review provides an overview of the TIF1 family in cancer, focusing on their roles in DNA repair, chromatin regulation and cell cycle regulation. |
| first_indexed | 2024-03-10T18:08:55Z |
| format | Article |
| id | doaj.art-42df7cc8999e4a36a08fc7b8eef40eab |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T18:08:55Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-42df7cc8999e4a36a08fc7b8eef40eab2023-11-20T08:14:29ZengMDPI AGCancers2072-66942020-07-01128209410.3390/cancers12082094TIF1 Proteins in Genome Stability and CancerRoisin M. McAvera0Lisa J. Crawford1Patrick G Johnston Centre for Cancer Research, Queen’s University Belfast, Belfast BT9 7AE, UKPatrick G Johnston Centre for Cancer Research, Queen’s University Belfast, Belfast BT9 7AE, UKGenomic instability is a hallmark of cancer cells which results in excessive DNA damage. To counteract this, cells have evolved a tightly regulated DNA damage response (DDR) to rapidly sense DNA damage and promote its repair whilst halting cell cycle progression. The DDR functions predominantly within the context of chromatin and requires the action of chromatin-binding proteins to coordinate the appropriate response. TRIM24, TRIM28, TRIM33 and TRIM66 make up the transcriptional intermediary factor 1 (TIF1) family of chromatin-binding proteins, a subfamily of the large tripartite motif (TRIM) family of E3 ligases. All four TIF1 proteins are aberrantly expressed across numerous cancer types, and increasing evidence suggests that TIF1 family members can function to maintain genome stability by mediating chromatin-based responses to DNA damage. This review provides an overview of the TIF1 family in cancer, focusing on their roles in DNA repair, chromatin regulation and cell cycle regulation.https://www.mdpi.com/2072-6694/12/8/2094TRIM24TRIM28TRIM33TRIM66genome stabilityDNA damage |
| spellingShingle | Roisin M. McAvera Lisa J. Crawford TIF1 Proteins in Genome Stability and Cancer Cancers TRIM24 TRIM28 TRIM33 TRIM66 genome stability DNA damage |
| title | TIF1 Proteins in Genome Stability and Cancer |
| title_full | TIF1 Proteins in Genome Stability and Cancer |
| title_fullStr | TIF1 Proteins in Genome Stability and Cancer |
| title_full_unstemmed | TIF1 Proteins in Genome Stability and Cancer |
| title_short | TIF1 Proteins in Genome Stability and Cancer |
| title_sort | tif1 proteins in genome stability and cancer |
| topic | TRIM24 TRIM28 TRIM33 TRIM66 genome stability DNA damage |
| url | https://www.mdpi.com/2072-6694/12/8/2094 |
| work_keys_str_mv | AT roisinmmcavera tif1proteinsingenomestabilityandcancer AT lisajcrawford tif1proteinsingenomestabilityandcancer |