Immune response to Leishmania (Leishmania) chagasi infection is reduced in malnourished BALB/c mice
Protein-energy malnutrition and micronutrient deficiencies may down-regulate immune response and increase morbidity and mortality due to infection. In this study, a murine model was used to study the effects of protein, iron and zinc deficiencies on the immune response to Leishmania (Leishmania) cha...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2010-09-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000600014 |
| _version_ | 1797715773771218944 |
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| author | Tiago Donatelli Serafim Guilherme Malafaia Marcelo Eustáquio Silva Maria Lúcia Pedrosa Simone Aparecida Rezende |
| author_facet | Tiago Donatelli Serafim Guilherme Malafaia Marcelo Eustáquio Silva Maria Lúcia Pedrosa Simone Aparecida Rezende |
| author_sort | Tiago Donatelli Serafim |
| collection | DOAJ |
| description | Protein-energy malnutrition and micronutrient deficiencies may down-regulate immune response and increase morbidity and mortality due to infection. In this study, a murine model was used to study the effects of protein, iron and zinc deficiencies on the immune response to Leishmania (Leishmania) chagasi infection. Mice were initially fed a standard diet or with a diet containing 3% casein but deficient in zinc and iron. After malnutrition was established, mice were inoculated with L. chagasiand sacrificed four weeks later in order to evaluate liver and spleen parasite loads and serum biochemical parameters. Significant decreases in liver and spleen weight, an increase in the parasite loads in these organs and decreases in serum protein and glucose concentrations in malnourished animals were observed. Furthermore, the production of interferon-gamma by spleen cells from infected malnourished mice stimulated by Leishmaniaantigen was significantly lower compared with that in control diet mice. These data suggest that malnutrition alters the immune response to L. chagasiinfection in the BALB/c model and, in association with the effects on biochemical and anatomical parameters of the host, favored increases in the parasite loads in the spleens and livers of these animals. |
| first_indexed | 2024-03-12T08:11:41Z |
| format | Article |
| id | doaj.art-42df9b33421f42e99f6ba7f3ed3964bb |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:11:41Z |
| publishDate | 2010-09-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-42df9b33421f42e99f6ba7f3ed3964bb2023-09-02T19:06:47ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602010-09-01105681181710.1590/S0074-02762010000600014Immune response to Leishmania (Leishmania) chagasi infection is reduced in malnourished BALB/c miceTiago Donatelli SerafimGuilherme MalafaiaMarcelo Eustáquio SilvaMaria Lúcia PedrosaSimone Aparecida RezendeProtein-energy malnutrition and micronutrient deficiencies may down-regulate immune response and increase morbidity and mortality due to infection. In this study, a murine model was used to study the effects of protein, iron and zinc deficiencies on the immune response to Leishmania (Leishmania) chagasi infection. Mice were initially fed a standard diet or with a diet containing 3% casein but deficient in zinc and iron. After malnutrition was established, mice were inoculated with L. chagasiand sacrificed four weeks later in order to evaluate liver and spleen parasite loads and serum biochemical parameters. Significant decreases in liver and spleen weight, an increase in the parasite loads in these organs and decreases in serum protein and glucose concentrations in malnourished animals were observed. Furthermore, the production of interferon-gamma by spleen cells from infected malnourished mice stimulated by Leishmaniaantigen was significantly lower compared with that in control diet mice. These data suggest that malnutrition alters the immune response to L. chagasiinfection in the BALB/c model and, in association with the effects on biochemical and anatomical parameters of the host, favored increases in the parasite loads in the spleens and livers of these animals.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000600014visceral leishmaniasismalnutritionLeishmania chagasiBALB/cinterleukin 4interferon-gamma |
| spellingShingle | Tiago Donatelli Serafim Guilherme Malafaia Marcelo Eustáquio Silva Maria Lúcia Pedrosa Simone Aparecida Rezende Immune response to Leishmania (Leishmania) chagasi infection is reduced in malnourished BALB/c mice Memorias do Instituto Oswaldo Cruz visceral leishmaniasis malnutrition Leishmania chagasi BALB/c interleukin 4 interferon-gamma |
| title | Immune response to Leishmania (Leishmania) chagasi infection is reduced in malnourished BALB/c mice |
| title_full | Immune response to Leishmania (Leishmania) chagasi infection is reduced in malnourished BALB/c mice |
| title_fullStr | Immune response to Leishmania (Leishmania) chagasi infection is reduced in malnourished BALB/c mice |
| title_full_unstemmed | Immune response to Leishmania (Leishmania) chagasi infection is reduced in malnourished BALB/c mice |
| title_short | Immune response to Leishmania (Leishmania) chagasi infection is reduced in malnourished BALB/c mice |
| title_sort | immune response to leishmania leishmania chagasi infection is reduced in malnourished balb c mice |
| topic | visceral leishmaniasis malnutrition Leishmania chagasi BALB/c interleukin 4 interferon-gamma |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000600014 |
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