Triiodothyronine Mitigates Cardiac Dysfunction in Aluminum Phosphide Poisoning: Findings from a Randomized Clinical Trial
Introduction: Aluminum phosphide (AlP) poisoning, commonly known as rice tablet poisoning, is a lethal method of suicide with no known antidotes. Thyroid hormones have inotropic effects that can potentially reverse hemodynamic instability and improve cardiac output. This study investigated the effec...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2023-07-01
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| Series: | Asia Pacific Journal of Medical Toxicology |
| Subjects: | |
| Online Access: | https://apjmt.mums.ac.ir/article_22797_76e0e3ffcdd2e46d2126523450a38f5c.pdf |
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| author | Seyed Reza Mousavi Zeinab Ayoubi Maryam Vahabzadeh Lida Jarahi Khadijeh Abdi Valami Hamid Reza Rahimi |
| author_facet | Seyed Reza Mousavi Zeinab Ayoubi Maryam Vahabzadeh Lida Jarahi Khadijeh Abdi Valami Hamid Reza Rahimi |
| author_sort | Seyed Reza Mousavi |
| collection | DOAJ |
| description | Introduction: Aluminum phosphide (AlP) poisoning, commonly known as rice tablet poisoning, is a lethal method of suicide with no known antidotes. Thyroid hormones have inotropic effects that can potentially reverse hemodynamic instability and improve cardiac output. This study investigated the effects of Triiodothyronine (T3) on the cardiac function of patients with aluminum phosphide poisoning.Methods: In this randomized clinical trial, 24 patients with confirmed ALP poisoning were recruited. The intervention group received T3 treatment in addition to standard treatment, while the control group received only standard treatment. Demographic variables, cardiac parameters, biochemical markers, and oxidative stress tests were evaluated.Results: The majority of participants were men (60%) in their thirties (intervention: 32±17.4 years; control: 30±11.6 years). Following treatment, both systolic and diastolic blood pressures had significantly higher mean differences in the T3 group compared to the control group (18.7±9.3, P=0.05 and 14.1±5.9, P=0.03 respectively). While both groups showed improvement in mean arterial pH, the intervention group exhibited a significantly greater improvement 12 hours after the administration of T3, which was significantly different from both the baseline and control groups (p=0.04, 0.009 respectively). Additionally, the intervention group had a lower QRS and QTc interval compared to admission time.Conclusion: Triiodothyronine administration has been shown to maintain a higher range of SBP, control cardiogenic shock, regulate metabolism, improve acidosis and blood pressure, and ultimately enhance recovery in patients with aluminum phosphide poisoning. Furthermore, it may have cardio-protective effects on these patients. |
| first_indexed | 2024-03-12T15:06:11Z |
| format | Article |
| id | doaj.art-42e09a070b214306905ed83d135b4864 |
| institution | Directory Open Access Journal |
| issn | 2322-2611 2322-4320 |
| language | English |
| last_indexed | 2024-03-12T15:06:11Z |
| publishDate | 2023-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Asia Pacific Journal of Medical Toxicology |
| spelling | doaj.art-42e09a070b214306905ed83d135b48642023-08-12T14:38:01ZengMashhad University of Medical SciencesAsia Pacific Journal of Medical Toxicology2322-26112322-43202023-07-01122545910.22038/apjmt.2023.2279722797Triiodothyronine Mitigates Cardiac Dysfunction in Aluminum Phosphide Poisoning: Findings from a Randomized Clinical TrialSeyed Reza Mousavi0Zeinab Ayoubi1Maryam Vahabzadeh2Lida Jarahi3Khadijeh Abdi Valami4Hamid Reza Rahimi5Department of Forensic Medicine and Clinical Toxicology, Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Forensic Medicine and Clinical Toxicology, Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Forensic Medicine and Clinical Toxicology, Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Forensic Medicine and Clinical Toxicology, Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Medical Genetics and Molecular Medicine, Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Introduction: Aluminum phosphide (AlP) poisoning, commonly known as rice tablet poisoning, is a lethal method of suicide with no known antidotes. Thyroid hormones have inotropic effects that can potentially reverse hemodynamic instability and improve cardiac output. This study investigated the effects of Triiodothyronine (T3) on the cardiac function of patients with aluminum phosphide poisoning.Methods: In this randomized clinical trial, 24 patients with confirmed ALP poisoning were recruited. The intervention group received T3 treatment in addition to standard treatment, while the control group received only standard treatment. Demographic variables, cardiac parameters, biochemical markers, and oxidative stress tests were evaluated.Results: The majority of participants were men (60%) in their thirties (intervention: 32±17.4 years; control: 30±11.6 years). Following treatment, both systolic and diastolic blood pressures had significantly higher mean differences in the T3 group compared to the control group (18.7±9.3, P=0.05 and 14.1±5.9, P=0.03 respectively). While both groups showed improvement in mean arterial pH, the intervention group exhibited a significantly greater improvement 12 hours after the administration of T3, which was significantly different from both the baseline and control groups (p=0.04, 0.009 respectively). Additionally, the intervention group had a lower QRS and QTc interval compared to admission time.Conclusion: Triiodothyronine administration has been shown to maintain a higher range of SBP, control cardiogenic shock, regulate metabolism, improve acidosis and blood pressure, and ultimately enhance recovery in patients with aluminum phosphide poisoning. Furthermore, it may have cardio-protective effects on these patients.https://apjmt.mums.ac.ir/article_22797_76e0e3ffcdd2e46d2126523450a38f5c.pdfaluminum phosphidephosphinepoisoningtriiodothyronine |
| spellingShingle | Seyed Reza Mousavi Zeinab Ayoubi Maryam Vahabzadeh Lida Jarahi Khadijeh Abdi Valami Hamid Reza Rahimi Triiodothyronine Mitigates Cardiac Dysfunction in Aluminum Phosphide Poisoning: Findings from a Randomized Clinical Trial Asia Pacific Journal of Medical Toxicology aluminum phosphide phosphine poisoning triiodothyronine |
| title | Triiodothyronine Mitigates Cardiac Dysfunction in Aluminum Phosphide Poisoning: Findings from a Randomized Clinical Trial |
| title_full | Triiodothyronine Mitigates Cardiac Dysfunction in Aluminum Phosphide Poisoning: Findings from a Randomized Clinical Trial |
| title_fullStr | Triiodothyronine Mitigates Cardiac Dysfunction in Aluminum Phosphide Poisoning: Findings from a Randomized Clinical Trial |
| title_full_unstemmed | Triiodothyronine Mitigates Cardiac Dysfunction in Aluminum Phosphide Poisoning: Findings from a Randomized Clinical Trial |
| title_short | Triiodothyronine Mitigates Cardiac Dysfunction in Aluminum Phosphide Poisoning: Findings from a Randomized Clinical Trial |
| title_sort | triiodothyronine mitigates cardiac dysfunction in aluminum phosphide poisoning findings from a randomized clinical trial |
| topic | aluminum phosphide phosphine poisoning triiodothyronine |
| url | https://apjmt.mums.ac.ir/article_22797_76e0e3ffcdd2e46d2126523450a38f5c.pdf |
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