Transgenerational inheritance of impaired larval T cell development in zebrafish

Evidence for transgenerational inheritance of epigenetic information in vertebrates is scarce. Here the authors report that homozygous dnmt1 mutant zebrafish are essentially normal, with the exception of impaired lymphopoiesis, with impaired larval (but not adult) T cell development being transmitte...

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Bibliographic Details
Main Authors: Norimasa Iwanami, Divine-Fondzenyuy Lawir, Katarzyna Sikora, Connor O´Meara, Kohei Takeshita, Michael Schorpp, Thomas Boehm
Format: Article
Language:English
Published: Nature Portfolio 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18289-9