The fraction of lung cancer incidence attributable to fine particulate air pollution in France: Impact of spatial resolution of air pollution models
Outdoor air pollution is a leading environmental cause of death and cancer incidence in humans. We aimed to estimate the fraction of lung cancer incidence attributable to fine particulate matter (PM2.5) exposure in France, and secondarily to illustrate the influence of the input data and the spatial...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-12-01
|
| Series: | Environment International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412018312236 |
| _version_ | 1828804612002414592 |
|---|---|
| author | Ivana Kulhánová Xavier Morelli Alain Le Tertre Dana Loomis Barbara Charbotel Sylvia Medina Jean-Nicolas Ormsby Johanna Lepeule Rémy Slama Isabelle Soerjomataram |
| author_facet | Ivana Kulhánová Xavier Morelli Alain Le Tertre Dana Loomis Barbara Charbotel Sylvia Medina Jean-Nicolas Ormsby Johanna Lepeule Rémy Slama Isabelle Soerjomataram |
| author_sort | Ivana Kulhánová |
| collection | DOAJ |
| description | Outdoor air pollution is a leading environmental cause of death and cancer incidence in humans. We aimed to estimate the fraction of lung cancer incidence attributable to fine particulate matter (PM2.5) exposure in France, and secondarily to illustrate the influence of the input data and the spatial resolution of information on air pollution levels on this estimate. The population attributable fraction (PAF) was estimated using a nationwide spatially refined chemistry-transport model with a 2-km spatial resolution, neighbourhood-scale population density data, and a relative risk from a published meta-analysis. We used the WHO guideline value for PM2.5 exposure (10 μg/m3) as reference. Sensitivity analyses consisted in attributing the nation-wide median exposure to all areas and using alternative input data such as reference of PM2.5 exposure level and relative risk. Population-weighted median PM2.5 level in 2005 was 13.8 μg/m3; 87% of the population was exposed above the guideline value. The burden of lung cancer attributable to PM2.5 exposure corresponded to 1466 cases, or 3.6% of all cases diagnosed in 2015. Sensitivity analyses showed that the use of a national median of PM2.5 exposure would have led to an underestimation of the PAF by 11% (population-weighted median) and by 72% (median of raw concentration), suggesting that our estimates would have been higher with even more finely spatially-resolved models. When the PM2.5 reference level was replaced by the 5th percentile of country-scale exposure (4.9 μg/m3), PAF increased to 7.6%. Other sensitivity analyses resulted in even higher PAFs. Improvements in air pollution are crucial for quantitative health impacts assessment studies. Actions to reduce PM2.5 levels could substantially reduce the burden of lung cancer in France. Keywords: Air pollution, Lung cancer, Population attributable fraction, France |
| first_indexed | 2024-12-12T07:43:04Z |
| format | Article |
| id | doaj.art-42e37c42c6d244f7a23001717d13609e |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-12T07:43:04Z |
| publishDate | 2018-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-42e37c42c6d244f7a23001717d13609e2022-12-22T00:32:44ZengElsevierEnvironment International0160-41202018-12-0112110791086The fraction of lung cancer incidence attributable to fine particulate air pollution in France: Impact of spatial resolution of air pollution modelsIvana Kulhánová0Xavier Morelli1Alain Le Tertre2Dana Loomis3Barbara Charbotel4Sylvia Medina5Jean-Nicolas Ormsby6Johanna Lepeule7Rémy Slama8Isabelle Soerjomataram9Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France; Corresponding author at: Section of Cancer Surveillance, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon, France.Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France; Department of Cancer and Environment, Centre Léon Bérard, Lyon, FranceSanté publique France, Paris, FranceMonographs Section, International Agency for Research on Cancer, Lyon, FranceUniversité de Lyon, Université Claude Bernard Lyon 1, IFSTTAR, UMRESTTE, UMR_T9405, Lyon, France; Service des maladies professionnelles, Hospices Civils de Lyon, Lyon, FranceSanté publique France, Paris, FranceFrench Agency for Food, Environmental and Occupational Health & Safety, Maisons-Alfort, FranceInserm, CNRS, University Grenoble-Alpes, IAB (Institute for Advanced Biosciences), Team of Environmental Epidemiology, Grenoble, FranceInserm, CNRS, University Grenoble-Alpes, IAB (Institute for Advanced Biosciences), Team of Environmental Epidemiology, Grenoble, FranceSection of Cancer Surveillance, International Agency for Research on Cancer, Lyon, FranceOutdoor air pollution is a leading environmental cause of death and cancer incidence in humans. We aimed to estimate the fraction of lung cancer incidence attributable to fine particulate matter (PM2.5) exposure in France, and secondarily to illustrate the influence of the input data and the spatial resolution of information on air pollution levels on this estimate. The population attributable fraction (PAF) was estimated using a nationwide spatially refined chemistry-transport model with a 2-km spatial resolution, neighbourhood-scale population density data, and a relative risk from a published meta-analysis. We used the WHO guideline value for PM2.5 exposure (10 μg/m3) as reference. Sensitivity analyses consisted in attributing the nation-wide median exposure to all areas and using alternative input data such as reference of PM2.5 exposure level and relative risk. Population-weighted median PM2.5 level in 2005 was 13.8 μg/m3; 87% of the population was exposed above the guideline value. The burden of lung cancer attributable to PM2.5 exposure corresponded to 1466 cases, or 3.6% of all cases diagnosed in 2015. Sensitivity analyses showed that the use of a national median of PM2.5 exposure would have led to an underestimation of the PAF by 11% (population-weighted median) and by 72% (median of raw concentration), suggesting that our estimates would have been higher with even more finely spatially-resolved models. When the PM2.5 reference level was replaced by the 5th percentile of country-scale exposure (4.9 μg/m3), PAF increased to 7.6%. Other sensitivity analyses resulted in even higher PAFs. Improvements in air pollution are crucial for quantitative health impacts assessment studies. Actions to reduce PM2.5 levels could substantially reduce the burden of lung cancer in France. Keywords: Air pollution, Lung cancer, Population attributable fraction, Francehttp://www.sciencedirect.com/science/article/pii/S0160412018312236 |
| spellingShingle | Ivana Kulhánová Xavier Morelli Alain Le Tertre Dana Loomis Barbara Charbotel Sylvia Medina Jean-Nicolas Ormsby Johanna Lepeule Rémy Slama Isabelle Soerjomataram The fraction of lung cancer incidence attributable to fine particulate air pollution in France: Impact of spatial resolution of air pollution models Environment International |
| title | The fraction of lung cancer incidence attributable to fine particulate air pollution in France: Impact of spatial resolution of air pollution models |
| title_full | The fraction of lung cancer incidence attributable to fine particulate air pollution in France: Impact of spatial resolution of air pollution models |
| title_fullStr | The fraction of lung cancer incidence attributable to fine particulate air pollution in France: Impact of spatial resolution of air pollution models |
| title_full_unstemmed | The fraction of lung cancer incidence attributable to fine particulate air pollution in France: Impact of spatial resolution of air pollution models |
| title_short | The fraction of lung cancer incidence attributable to fine particulate air pollution in France: Impact of spatial resolution of air pollution models |
| title_sort | fraction of lung cancer incidence attributable to fine particulate air pollution in france impact of spatial resolution of air pollution models |
| url | http://www.sciencedirect.com/science/article/pii/S0160412018312236 |
| work_keys_str_mv | AT ivanakulhanova thefractionoflungcancerincidenceattributabletofineparticulateairpollutioninfranceimpactofspatialresolutionofairpollutionmodels AT xaviermorelli thefractionoflungcancerincidenceattributabletofineparticulateairpollutioninfranceimpactofspatialresolutionofairpollutionmodels AT alainletertre thefractionoflungcancerincidenceattributabletofineparticulateairpollutioninfranceimpactofspatialresolutionofairpollutionmodels AT danaloomis thefractionoflungcancerincidenceattributabletofineparticulateairpollutioninfranceimpactofspatialresolutionofairpollutionmodels AT barbaracharbotel thefractionoflungcancerincidenceattributabletofineparticulateairpollutioninfranceimpactofspatialresolutionofairpollutionmodels AT sylviamedina thefractionoflungcancerincidenceattributabletofineparticulateairpollutioninfranceimpactofspatialresolutionofairpollutionmodels AT jeannicolasormsby thefractionoflungcancerincidenceattributabletofineparticulateairpollutioninfranceimpactofspatialresolutionofairpollutionmodels AT johannalepeule thefractionoflungcancerincidenceattributabletofineparticulateairpollutioninfranceimpactofspatialresolutionofairpollutionmodels AT remyslama thefractionoflungcancerincidenceattributabletofineparticulateairpollutioninfranceimpactofspatialresolutionofairpollutionmodels AT isabellesoerjomataram thefractionoflungcancerincidenceattributabletofineparticulateairpollutioninfranceimpactofspatialresolutionofairpollutionmodels AT ivanakulhanova fractionoflungcancerincidenceattributabletofineparticulateairpollutioninfranceimpactofspatialresolutionofairpollutionmodels AT xaviermorelli fractionoflungcancerincidenceattributabletofineparticulateairpollutioninfranceimpactofspatialresolutionofairpollutionmodels AT alainletertre fractionoflungcancerincidenceattributabletofineparticulateairpollutioninfranceimpactofspatialresolutionofairpollutionmodels AT danaloomis fractionoflungcancerincidenceattributabletofineparticulateairpollutioninfranceimpactofspatialresolutionofairpollutionmodels AT barbaracharbotel fractionoflungcancerincidenceattributabletofineparticulateairpollutioninfranceimpactofspatialresolutionofairpollutionmodels AT sylviamedina fractionoflungcancerincidenceattributabletofineparticulateairpollutioninfranceimpactofspatialresolutionofairpollutionmodels AT jeannicolasormsby fractionoflungcancerincidenceattributabletofineparticulateairpollutioninfranceimpactofspatialresolutionofairpollutionmodels AT johannalepeule fractionoflungcancerincidenceattributabletofineparticulateairpollutioninfranceimpactofspatialresolutionofairpollutionmodels AT remyslama fractionoflungcancerincidenceattributabletofineparticulateairpollutioninfranceimpactofspatialresolutionofairpollutionmodels AT isabellesoerjomataram fractionoflungcancerincidenceattributabletofineparticulateairpollutioninfranceimpactofspatialresolutionofairpollutionmodels |