Development of Compositions and Technologies for Producing Tablets with Hydroxythyrozol-standardized Extract of Olive Leaves
Introduction. The article presents the results of a study of the physicochemical properties of dry extract of olive leaves, standardized by hydroxythyrozol - a biologically active substance that is part of the chemical composition of aerial parts of the olive tree.Aim. The purpose of the study is to...
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2021-08-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/998 |
| _version_ | 1797874952584560640 |
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| author | M. S. Maslennikova N. L. Solovyova |
| author_facet | M. S. Maslennikova N. L. Solovyova |
| author_sort | M. S. Maslennikova |
| collection | DOAJ |
| description | Introduction. The article presents the results of a study of the physicochemical properties of dry extract of olive leaves, standardized by hydroxythyrozol - a biologically active substance that is part of the chemical composition of aerial parts of the olive tree.Aim. The purpose of the study is to develop tablet Formulations containing dry extract of olive leaves and to standardize by hydroxythyrozol by reversed-phase-HPLC method on the main substancecontent.Materials and methods. Substance of dry extract of olive leaves, microcrystalline cellulose (Avicel® PH-112), Aerosil® (Aeroperl® 300 Pharma), Ludipress® (Ludipress®), lactose, potato starch, sodium salt of carboxymethyl starch, magnesium stearate, direct pressing, HPLC.Results and discussion. Studies of the physicochemical properties of dry extract of olive leaves have been carried out. Selected excipients for the study of tablettable masses. Formulations for further tabletting have been developed. A complex of studies of the obtained tablets was carried out according to Russian Pharmacopoeia XIV for compliance with quality indicators.Conclusion. The biological properties of dry extract of olive leaves are have been studied, indicating the prospect of developing drugs based on it. Formulations of tablets with dry extract of olive leaves have been developed and their quality indicators have been investigated. |
| first_indexed | 2024-04-10T01:38:58Z |
| format | Article |
| id | doaj.art-42e972620b9144cc9f6134ad59b950ce |
| institution | Directory Open Access Journal |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| last_indexed | 2024-04-10T01:38:58Z |
| publishDate | 2021-08-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj.art-42e972620b9144cc9f6134ad59b950ce2023-03-13T09:14:02ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492021-08-01103475310.33380/2305-2066-2021-10-3-47-53847Development of Compositions and Technologies for Producing Tablets with Hydroxythyrozol-standardized Extract of Olive LeavesM. S. Maslennikova0N. L. Solovyova1ФИЦ питания, биотехнологии и безопасности пищиИнститут Фармации им. А.П. Нелюбина, Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет)Introduction. The article presents the results of a study of the physicochemical properties of dry extract of olive leaves, standardized by hydroxythyrozol - a biologically active substance that is part of the chemical composition of aerial parts of the olive tree.Aim. The purpose of the study is to develop tablet Formulations containing dry extract of olive leaves and to standardize by hydroxythyrozol by reversed-phase-HPLC method on the main substancecontent.Materials and methods. Substance of dry extract of olive leaves, microcrystalline cellulose (Avicel® PH-112), Aerosil® (Aeroperl® 300 Pharma), Ludipress® (Ludipress®), lactose, potato starch, sodium salt of carboxymethyl starch, magnesium stearate, direct pressing, HPLC.Results and discussion. Studies of the physicochemical properties of dry extract of olive leaves have been carried out. Selected excipients for the study of tablettable masses. Formulations for further tabletting have been developed. A complex of studies of the obtained tablets was carried out according to Russian Pharmacopoeia XIV for compliance with quality indicators.Conclusion. The biological properties of dry extract of olive leaves are have been studied, indicating the prospect of developing drugs based on it. Formulations of tablets with dry extract of olive leaves have been developed and their quality indicators have been investigated.https://www.pharmjournal.ru/jour/article/view/998гидрокситирозолполифенолысухой экстракт листьев оливывспомогательные веществаоф-вэжх |
| spellingShingle | M. S. Maslennikova N. L. Solovyova Development of Compositions and Technologies for Producing Tablets with Hydroxythyrozol-standardized Extract of Olive Leaves Разработка и регистрация лекарственных средств гидрокситирозол полифенолы сухой экстракт листьев оливы вспомогательные вещества оф-вэжх |
| title | Development of Compositions and Technologies for Producing Tablets with Hydroxythyrozol-standardized Extract of Olive Leaves |
| title_full | Development of Compositions and Technologies for Producing Tablets with Hydroxythyrozol-standardized Extract of Olive Leaves |
| title_fullStr | Development of Compositions and Technologies for Producing Tablets with Hydroxythyrozol-standardized Extract of Olive Leaves |
| title_full_unstemmed | Development of Compositions and Technologies for Producing Tablets with Hydroxythyrozol-standardized Extract of Olive Leaves |
| title_short | Development of Compositions and Technologies for Producing Tablets with Hydroxythyrozol-standardized Extract of Olive Leaves |
| title_sort | development of compositions and technologies for producing tablets with hydroxythyrozol standardized extract of olive leaves |
| topic | гидрокситирозол полифенолы сухой экстракт листьев оливы вспомогательные вещества оф-вэжх |
| url | https://www.pharmjournal.ru/jour/article/view/998 |
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