Effects of high sucrose diets and 4-aminopyrazolopyrimidine on serum lipids and lipoproteins in the rat
The effect of feeding a semipurified diet high in sucrose on serum lipid and lipoprotein concentrations was studied. In rats fed this diet the serum triglyceride concentration doubled, and liver triglyceride concentration increased by 30%. A fivefold increase in VLDL protein concentration and a smal...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
1971-09-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520394797 |
| _version_ | 1818385611995742208 |
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| author | T.S. SHIFF P.S. ROHEIM H.A. EDER |
| author_facet | T.S. SHIFF P.S. ROHEIM H.A. EDER |
| author_sort | T.S. SHIFF |
| collection | DOAJ |
| description | The effect of feeding a semipurified diet high in sucrose on serum lipid and lipoprotein concentrations was studied. In rats fed this diet the serum triglyceride concentration doubled, and liver triglyceride concentration increased by 30%. A fivefold increase in VLDL protein concentration and a small but significant increase of HDL protein concentration was also observed. In these rats there was increased incorporation of labeled amino acids into the proteins of plasma VLDL and HDL.Fatty livers developed in the animals receiving 4-aminopyrazolopyrimidine, and levels of serum triglyceride and cholesterol fell markedly. The concentration of all lipoprotein classes decreased, with VLDL showing the most marked effect. Incorporation of labeled amino acids into lipoproteins and other plasma proteins was depressed. |
| first_indexed | 2024-12-14T03:40:55Z |
| format | Article |
| id | doaj.art-42ed6b570116453191bee65ed248e73e |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-14T03:40:55Z |
| publishDate | 1971-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-42ed6b570116453191bee65ed248e73e2022-12-21T23:18:29ZengElsevierJournal of Lipid Research0022-22751971-09-01125596603Effects of high sucrose diets and 4-aminopyrazolopyrimidine on serum lipids and lipoproteins in the ratT.S. SHIFF0P.S. ROHEIM1H.A. EDER2Departments of Medicine and Physiology, Albert Einstein College of Medicine, Bronx, New York 10461Departments of Medicine and Physiology, Albert Einstein College of Medicine, Bronx, New York 10461Departments of Medicine and Physiology, Albert Einstein College of Medicine, Bronx, New York 10461The effect of feeding a semipurified diet high in sucrose on serum lipid and lipoprotein concentrations was studied. In rats fed this diet the serum triglyceride concentration doubled, and liver triglyceride concentration increased by 30%. A fivefold increase in VLDL protein concentration and a small but significant increase of HDL protein concentration was also observed. In these rats there was increased incorporation of labeled amino acids into the proteins of plasma VLDL and HDL.Fatty livers developed in the animals receiving 4-aminopyrazolopyrimidine, and levels of serum triglyceride and cholesterol fell markedly. The concentration of all lipoprotein classes decreased, with VLDL showing the most marked effect. Incorporation of labeled amino acids into lipoproteins and other plasma proteins was depressed.http://www.sciencedirect.com/science/article/pii/S0022227520394797fatty liverserum triglyceridesserum cholesteroladeninehyperlipemiasynthesis of serum lipoproteins |
| spellingShingle | T.S. SHIFF P.S. ROHEIM H.A. EDER Effects of high sucrose diets and 4-aminopyrazolopyrimidine on serum lipids and lipoproteins in the rat Journal of Lipid Research fatty liver serum triglycerides serum cholesterol adenine hyperlipemia synthesis of serum lipoproteins |
| title | Effects of high sucrose diets and 4-aminopyrazolopyrimidine on serum lipids and lipoproteins in the rat |
| title_full | Effects of high sucrose diets and 4-aminopyrazolopyrimidine on serum lipids and lipoproteins in the rat |
| title_fullStr | Effects of high sucrose diets and 4-aminopyrazolopyrimidine on serum lipids and lipoproteins in the rat |
| title_full_unstemmed | Effects of high sucrose diets and 4-aminopyrazolopyrimidine on serum lipids and lipoproteins in the rat |
| title_short | Effects of high sucrose diets and 4-aminopyrazolopyrimidine on serum lipids and lipoproteins in the rat |
| title_sort | effects of high sucrose diets and 4 aminopyrazolopyrimidine on serum lipids and lipoproteins in the rat |
| topic | fatty liver serum triglycerides serum cholesterol adenine hyperlipemia synthesis of serum lipoproteins |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520394797 |
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