Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis.
<h4>Background</h4>Transient elastography (TE), a non-invasive tool that measures liver stiffness, has been evaluated in meta-analyses for effectiveness in assessing liver fibrosis in European populations with chronic hepatitis C (CHC). However, these data cannot be extrapolated to popul...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23049764/?tool=EBI |
| _version_ | 1818722983508705280 |
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| author | Young Eun Chon Eun Hee Choi Ki Jun Song Jun Yong Park Do Young Kim Kwang-Hyub Han Chae Yoon Chon Sang Hoon Ahn Seung Up Kim |
| author_facet | Young Eun Chon Eun Hee Choi Ki Jun Song Jun Yong Park Do Young Kim Kwang-Hyub Han Chae Yoon Chon Sang Hoon Ahn Seung Up Kim |
| author_sort | Young Eun Chon |
| collection | DOAJ |
| description | <h4>Background</h4>Transient elastography (TE), a non-invasive tool that measures liver stiffness, has been evaluated in meta-analyses for effectiveness in assessing liver fibrosis in European populations with chronic hepatitis C (CHC). However, these data cannot be extrapolated to populations in Asian countries, where chronic hepatitis B (CHB) is more prevalent. In this study, we performed a meta-analysis to assess the overall performance of TE for assessing liver fibrosis in patients with CHB.<h4>Methods</h4>Studies from the literature and international conference abstracts which enrolled only patients with CHB or performed a subgroup analysis of such patients were enrolled. Combined effects were calculated using area under the receiver operating characteristic curves (AUROC) and diagnostic accuracy values of each study.<h4>Result</h4>A total of 18 studies comprising 2,772 patients were analyzed. The mean AUROCs for the diagnosis of significant fibrosis (F2), severe fibrosis (F3), and cirrhosis (F4) were 0.859 (95% confidence interval [CI], 0.857-0.860), 0.887 (95% CI, 0.886-0.887), and 0.929 (95% CI, 0.928-0.929), respectively. The estimated cutoff for F2 was 7.9 (range, 6.1-11.8) kPa, with a sensitivity of 74.3% and specificity of 78.3%. For F3, the cutoff value was determined to be 8.8 (range, 8.1-9.7) kPa, with a sensitivity of 74.0% and specificity of 63.8%. The cutoff value for F4 was 11.7 (range, 7.3-17.5) kPa, with a sensitivity of 84.6% and specificity of 81.5%.<h4>Conclusion</h4>TE can be performed with good diagnostic accuracy for quantifying liver fibrosis in patients with CHB. |
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| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T21:03:18Z |
| publishDate | 2012-01-01 |
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| spelling | doaj.art-42eddf83a650488c9ee117125e2aabcc2022-12-21T21:32:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0179e4493010.1371/journal.pone.0044930Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis.Young Eun ChonEun Hee ChoiKi Jun SongJun Yong ParkDo Young KimKwang-Hyub HanChae Yoon ChonSang Hoon AhnSeung Up Kim<h4>Background</h4>Transient elastography (TE), a non-invasive tool that measures liver stiffness, has been evaluated in meta-analyses for effectiveness in assessing liver fibrosis in European populations with chronic hepatitis C (CHC). However, these data cannot be extrapolated to populations in Asian countries, where chronic hepatitis B (CHB) is more prevalent. In this study, we performed a meta-analysis to assess the overall performance of TE for assessing liver fibrosis in patients with CHB.<h4>Methods</h4>Studies from the literature and international conference abstracts which enrolled only patients with CHB or performed a subgroup analysis of such patients were enrolled. Combined effects were calculated using area under the receiver operating characteristic curves (AUROC) and diagnostic accuracy values of each study.<h4>Result</h4>A total of 18 studies comprising 2,772 patients were analyzed. The mean AUROCs for the diagnosis of significant fibrosis (F2), severe fibrosis (F3), and cirrhosis (F4) were 0.859 (95% confidence interval [CI], 0.857-0.860), 0.887 (95% CI, 0.886-0.887), and 0.929 (95% CI, 0.928-0.929), respectively. The estimated cutoff for F2 was 7.9 (range, 6.1-11.8) kPa, with a sensitivity of 74.3% and specificity of 78.3%. For F3, the cutoff value was determined to be 8.8 (range, 8.1-9.7) kPa, with a sensitivity of 74.0% and specificity of 63.8%. The cutoff value for F4 was 11.7 (range, 7.3-17.5) kPa, with a sensitivity of 84.6% and specificity of 81.5%.<h4>Conclusion</h4>TE can be performed with good diagnostic accuracy for quantifying liver fibrosis in patients with CHB.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23049764/?tool=EBI |
| spellingShingle | Young Eun Chon Eun Hee Choi Ki Jun Song Jun Yong Park Do Young Kim Kwang-Hyub Han Chae Yoon Chon Sang Hoon Ahn Seung Up Kim Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis. PLoS ONE |
| title | Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis. |
| title_full | Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis. |
| title_fullStr | Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis. |
| title_full_unstemmed | Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis. |
| title_short | Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis. |
| title_sort | performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis b a meta analysis |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23049764/?tool=EBI |
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