Increased interhemispheric functional connectivity after right anodal tDCS in chronic non-fluent aphasia: preliminary findings
IntroductionAnodal transcranial Direct Current Stimulation (tDCS) is a non-invasive, low-cost and environment-friendly brain neuromodulation technique that increases cortical excitability. In post-stroke aphasia, the role of the right hemisphere in language recovery remains debated. In this prelimin...
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| Format: | Article |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1346095/full |
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| author | Federica Alemanno Davide Fedeli Davide Fedeli Alessia Monti Elise Houdayer Pasquale Anthony Della Rosa Federica Zangrillo Daniele Emedoli Elisabetta Pelagallo Massimo Corbo Sandro Iannaccone Jubin Abutalebi Jubin Abutalebi |
| author_facet | Federica Alemanno Davide Fedeli Davide Fedeli Alessia Monti Elise Houdayer Pasquale Anthony Della Rosa Federica Zangrillo Daniele Emedoli Elisabetta Pelagallo Massimo Corbo Sandro Iannaccone Jubin Abutalebi Jubin Abutalebi |
| author_sort | Federica Alemanno |
| collection | DOAJ |
| description | IntroductionAnodal transcranial Direct Current Stimulation (tDCS) is a non-invasive, low-cost and environment-friendly brain neuromodulation technique that increases cortical excitability. In post-stroke aphasia, the role of the right hemisphere in language recovery remains debated. In this preliminary study, we aimed to investigate the efficacy of excitatory tDCS on the right hemisphere in chronic aphasic patients.MethodsWe applied anodal tDCS to the right homologous region of Broca’s area in four chronic aphasic patients while performing a one-month naming rehabilitation treatment. Longitudinal data on language assessment and naming performance were collected. Resting-state fMRI images were acquired before and after treatment to measure changes in functional connectivity.ResultsResults showed enhanced positive functional connectivity of the right Broca homologous with the left middle frontal and middle temporal gyri. Every patient showed improvements in language functions, but no major changes in naming performance.ConclusionThese preliminary findings suggest that tDCS applied over the unaffected hemisphere may result in longitudinal inter-hemispheric functional neuroplastic changes that could specifically improve language recovery and could potentially be included in therapeutic neurorehabilitative plans. |
| first_indexed | 2024-03-08T04:07:27Z |
| format | Article |
| id | doaj.art-42eebaeafcea48b3a0b5404fd19af924 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-08T04:07:27Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-42eebaeafcea48b3a0b5404fd19af9242024-02-09T04:41:14ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2024-02-011810.3389/fnins.2024.13460951346095Increased interhemispheric functional connectivity after right anodal tDCS in chronic non-fluent aphasia: preliminary findingsFederica Alemanno0Davide Fedeli1Davide Fedeli2Alessia Monti3Elise Houdayer4Pasquale Anthony Della Rosa5Federica Zangrillo6Daniele Emedoli7Elisabetta Pelagallo8Massimo Corbo9Sandro Iannaccone10Jubin Abutalebi11Jubin Abutalebi12Neuropsychology Service, Department of Rehabilitation and Functional Recovery, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, ItalyCentre for Neurolinguistics and Psycholinguistics, Scientific Institute San Raffaele, Vita-Salute San Raffaele University, Milan, ItalyDepartment of Neuroradiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, ItalyDepartment of Neurorehabilitation Sciences, Casa di Cura Igea, Milan, ItalyNeuropsychology Service, Department of Rehabilitation and Functional Recovery, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, ItalyDepartment of Neuroradiology, IRCCS San Raffaele Scientific Institute, Milan, ItalyNeuropsychology Service, Department of Rehabilitation and Functional Recovery, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, ItalyNeuropsychology Service, Department of Rehabilitation and Functional Recovery, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, ItalyNeuropsychology Service, Department of Rehabilitation and Functional Recovery, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, ItalyDepartment of Neurorehabilitation Sciences, Casa di Cura Igea, Milan, ItalyNeuropsychology Service, Department of Rehabilitation and Functional Recovery, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, ItalyNeuropsychology Service, Department of Rehabilitation and Functional Recovery, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, ItalyCentre for Neurolinguistics and Psycholinguistics, Scientific Institute San Raffaele, Vita-Salute San Raffaele University, Milan, ItalyIntroductionAnodal transcranial Direct Current Stimulation (tDCS) is a non-invasive, low-cost and environment-friendly brain neuromodulation technique that increases cortical excitability. In post-stroke aphasia, the role of the right hemisphere in language recovery remains debated. In this preliminary study, we aimed to investigate the efficacy of excitatory tDCS on the right hemisphere in chronic aphasic patients.MethodsWe applied anodal tDCS to the right homologous region of Broca’s area in four chronic aphasic patients while performing a one-month naming rehabilitation treatment. Longitudinal data on language assessment and naming performance were collected. Resting-state fMRI images were acquired before and after treatment to measure changes in functional connectivity.ResultsResults showed enhanced positive functional connectivity of the right Broca homologous with the left middle frontal and middle temporal gyri. Every patient showed improvements in language functions, but no major changes in naming performance.ConclusionThese preliminary findings suggest that tDCS applied over the unaffected hemisphere may result in longitudinal inter-hemispheric functional neuroplastic changes that could specifically improve language recovery and could potentially be included in therapeutic neurorehabilitative plans.https://www.frontiersin.org/articles/10.3389/fnins.2024.1346095/fullaphasiatranscranial direct current stimulationresting state fMRIlanguagestroke |
| spellingShingle | Federica Alemanno Davide Fedeli Davide Fedeli Alessia Monti Elise Houdayer Pasquale Anthony Della Rosa Federica Zangrillo Daniele Emedoli Elisabetta Pelagallo Massimo Corbo Sandro Iannaccone Jubin Abutalebi Jubin Abutalebi Increased interhemispheric functional connectivity after right anodal tDCS in chronic non-fluent aphasia: preliminary findings Frontiers in Neuroscience aphasia transcranial direct current stimulation resting state fMRI language stroke |
| title | Increased interhemispheric functional connectivity after right anodal tDCS in chronic non-fluent aphasia: preliminary findings |
| title_full | Increased interhemispheric functional connectivity after right anodal tDCS in chronic non-fluent aphasia: preliminary findings |
| title_fullStr | Increased interhemispheric functional connectivity after right anodal tDCS in chronic non-fluent aphasia: preliminary findings |
| title_full_unstemmed | Increased interhemispheric functional connectivity after right anodal tDCS in chronic non-fluent aphasia: preliminary findings |
| title_short | Increased interhemispheric functional connectivity after right anodal tDCS in chronic non-fluent aphasia: preliminary findings |
| title_sort | increased interhemispheric functional connectivity after right anodal tdcs in chronic non fluent aphasia preliminary findings |
| topic | aphasia transcranial direct current stimulation resting state fMRI language stroke |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1346095/full |
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