Recent advances in perinatal neuroprotection [version 1; peer review: 2 approved]
Perinatal brain injury is a major cause of neurological disability in both premature and term infants. In this review, we summarize the evidence behind some established neuroprotective practices such as administration of antenatal steroids, intrapartum magnesium for preterm delivery, and therapeutic...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2019-11-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/8-2031/v1 |
| _version_ | 1818912789394096128 |
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| author | Samata Singhi Michael Johnston |
| author_facet | Samata Singhi Michael Johnston |
| author_sort | Samata Singhi |
| collection | DOAJ |
| description | Perinatal brain injury is a major cause of neurological disability in both premature and term infants. In this review, we summarize the evidence behind some established neuroprotective practices such as administration of antenatal steroids, intrapartum magnesium for preterm delivery, and therapeutic hypothermia. In addition, we examine emerging practices such as delayed cord clamping, postnatal magnesium administration, recombinant erythropoietin, and non-steroidal anti-inflammatory agents and finally inform the reader about novel interventions, some of which are currently in trials, such as xenon, melatonin, topiramate, allopurinol, creatine, and autologous cord cell therapy. |
| first_indexed | 2024-12-19T23:20:11Z |
| format | Article |
| id | doaj.art-42ef44f93952410b8b244a720fd2dc2c |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-19T23:20:11Z |
| publishDate | 2019-11-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-42ef44f93952410b8b244a720fd2dc2c2022-12-21T20:01:59ZengF1000 Research LtdF1000Research2046-14022019-11-01810.12688/f1000research.20722.122790Recent advances in perinatal neuroprotection [version 1; peer review: 2 approved]Samata Singhi0Michael Johnston1Department of Neurology, Kennedy Krieger Institute, Baltimore, Maryland, 21205, USADepartment of Neurology, Kennedy Krieger Institute, Baltimore, Maryland, 21205, USAPerinatal brain injury is a major cause of neurological disability in both premature and term infants. In this review, we summarize the evidence behind some established neuroprotective practices such as administration of antenatal steroids, intrapartum magnesium for preterm delivery, and therapeutic hypothermia. In addition, we examine emerging practices such as delayed cord clamping, postnatal magnesium administration, recombinant erythropoietin, and non-steroidal anti-inflammatory agents and finally inform the reader about novel interventions, some of which are currently in trials, such as xenon, melatonin, topiramate, allopurinol, creatine, and autologous cord cell therapy.https://f1000research.com/articles/8-2031/v1 |
| spellingShingle | Samata Singhi Michael Johnston Recent advances in perinatal neuroprotection [version 1; peer review: 2 approved] F1000Research |
| title | Recent advances in perinatal neuroprotection [version 1; peer review: 2 approved] |
| title_full | Recent advances in perinatal neuroprotection [version 1; peer review: 2 approved] |
| title_fullStr | Recent advances in perinatal neuroprotection [version 1; peer review: 2 approved] |
| title_full_unstemmed | Recent advances in perinatal neuroprotection [version 1; peer review: 2 approved] |
| title_short | Recent advances in perinatal neuroprotection [version 1; peer review: 2 approved] |
| title_sort | recent advances in perinatal neuroprotection version 1 peer review 2 approved |
| url | https://f1000research.com/articles/8-2031/v1 |
| work_keys_str_mv | AT samatasinghi recentadvancesinperinatalneuroprotectionversion1peerreview2approved AT michaeljohnston recentadvancesinperinatalneuroprotectionversion1peerreview2approved |