Effects of Receptor Specificity and Conformational Stability of Influenza A Virus Hemagglutinin on Infection and Activation of Different Cell Types in Human PBMCs

Effects of Receptor Specificity and Conformational Stability of Influenza A Virus Hemagglutinin on Infection and Activation of Different Cell Types in Human PBMCs

Humans can be infected by zoonotic avian, pandemic and seasonal influenza A viruses (IAVs), which differ by receptor specificity and conformational stability of their envelope glycoprotein hemagglutinin (HA). It was shown that receptor specificity of the HA determines the tropism of IAVs to human ai...

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Bibliographic Details
Main Authors: Jens Dorna, Andreas Kaufmann, Viktoria Bockmann, Hartmann Raifer, Johanna West, Mikhail Matrosovich, Stefan Bauer
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
influenza
hemagglutinin
receptor specificity
primary immune cells
tropism
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.827760/full

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