Lipid Profile Changes in Pregnant Women with Pre-Eclampsia and Their Correlation with Severety of Pre-Eclampsia
Objectives: To find out whether there is a lipid profile changes in pregnant women with preeclampsia and if we can use these lipid profile changes as markers of the severity of preeclampsia (for follow up to avoid leaving the patient reaching ecplamptic stage). Design: A prospective case-co...
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| Format: | Article |
| Language: | English |
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College of Pharmacy / Mustansiriyah University
2020-09-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/766 |
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| author | Niran Kamel*, Wasan Munim Wasan Munim Alaa Raheem Kareem Mustafa Rasool Hussein Aal-Saleh Mohammed Luay Subhi Sarah Abdulkareem Ali Al-Dujaili |
| author_facet | Niran Kamel*, Wasan Munim Wasan Munim Alaa Raheem Kareem Mustafa Rasool Hussein Aal-Saleh Mohammed Luay Subhi Sarah Abdulkareem Ali Al-Dujaili |
| author_sort | Niran Kamel*, Wasan Munim |
| collection | DOAJ |
| description |
Objectives: To find out whether there is a lipid profile changes in pregnant women with preeclampsia and if we can use these lipid profile changes as markers of the severity of preeclampsia (for follow up to avoid leaving the patient reaching ecplamptic stage).
Design: A prospective case-control study.
Setting: AL- Kadhimiya Teaching hospital/department of Obstetrics and Gynecology.
Materials and Methods: The study included 120 pregnant women in the third trimester. They were divided into three groups. The study group consists of 60 preeclamptic and eclamptic women, 25 women had mild pre-eclampsia and 35 women with severe preeclampsia. The control group consists of 60 normotensive pregnant women. Blood sample was drown after 8-10 hours fasting. Triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol levels were measured.
Results: Triglyceride and VLDL-C level of severe Preeclampsia group and mild Preeclampsia group was higher than the control group, but the difference between the severe PE group and the control group was statistically significant (p<0.05). Serum cholesterol in the severe PE group was significantly higher than in mild PE group and in the control group (p<0.05). LDL-C and HDL-C levels were determined similarly in all groups (p>0.05). A highly significant positive correlation between the level of proteinuria and serum cholesterol levels, LDL-C, TG and VLDL-C levels. While there was significantly negative correlation between proteinuria and HDL-C levels. Also, a significant positive correlation between the systolic-tension and serum cholesterol levels, TG, VLDL-C levels and among the diastolic-tension and with LDL-C, TG, VLDL-C levels.
Conclusion: Changes in levels of lipid profile are related with preeclampsia, especially with severe preeclampsia.
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| first_indexed | 2024-04-24T13:43:46Z |
| format | Article |
| id | doaj.art-42f36968c63841cd9fedff2dbd4a8058 |
| institution | Directory Open Access Journal |
| issn | 1815-0993 2959-183X |
| language | English |
| last_indexed | 2024-04-24T13:43:46Z |
| publishDate | 2020-09-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj.art-42f36968c63841cd9fedff2dbd4a80582024-04-04T07:00:42ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2020-09-0120310.32947/ajps.v20i3.766Lipid Profile Changes in Pregnant Women with Pre-Eclampsia and Their Correlation with Severety of Pre-EclampsiaNiran Kamel*, Wasan Munim0Wasan Munim1Alaa Raheem Kareem2Mustafa Rasool Hussein Aal-Saleh3Mohammed Luay Subhi4Sarah Abdulkareem Ali Al-Dujaili5Al-Imamein Al Kadhimein Medical CityAl-Hakeem General HospitalAl-Imamein Al Kadhimein Medical CityBaghdad Teaching HospitalAl-Imamein Al Kadhimein Medical CityAl-Imamein Al Kadhimein Medical City Objectives: To find out whether there is a lipid profile changes in pregnant women with preeclampsia and if we can use these lipid profile changes as markers of the severity of preeclampsia (for follow up to avoid leaving the patient reaching ecplamptic stage). Design: A prospective case-control study. Setting: AL- Kadhimiya Teaching hospital/department of Obstetrics and Gynecology. Materials and Methods: The study included 120 pregnant women in the third trimester. They were divided into three groups. The study group consists of 60 preeclamptic and eclamptic women, 25 women had mild pre-eclampsia and 35 women with severe preeclampsia. The control group consists of 60 normotensive pregnant women. Blood sample was drown after 8-10 hours fasting. Triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol levels were measured. Results: Triglyceride and VLDL-C level of severe Preeclampsia group and mild Preeclampsia group was higher than the control group, but the difference between the severe PE group and the control group was statistically significant (p<0.05). Serum cholesterol in the severe PE group was significantly higher than in mild PE group and in the control group (p<0.05). LDL-C and HDL-C levels were determined similarly in all groups (p>0.05). A highly significant positive correlation between the level of proteinuria and serum cholesterol levels, LDL-C, TG and VLDL-C levels. While there was significantly negative correlation between proteinuria and HDL-C levels. Also, a significant positive correlation between the systolic-tension and serum cholesterol levels, TG, VLDL-C levels and among the diastolic-tension and with LDL-C, TG, VLDL-C levels. Conclusion: Changes in levels of lipid profile are related with preeclampsia, especially with severe preeclampsia. https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/766: Lipid profile, pregnancy, severe pre-eclampsia |
| spellingShingle | Niran Kamel*, Wasan Munim Wasan Munim Alaa Raheem Kareem Mustafa Rasool Hussein Aal-Saleh Mohammed Luay Subhi Sarah Abdulkareem Ali Al-Dujaili Lipid Profile Changes in Pregnant Women with Pre-Eclampsia and Their Correlation with Severety of Pre-Eclampsia Al-Mustansiriyah Journal of Pharmaceutical Sciences : Lipid profile, pregnancy, severe pre-eclampsia |
| title | Lipid Profile Changes in Pregnant Women with Pre-Eclampsia and Their Correlation with Severety of Pre-Eclampsia |
| title_full | Lipid Profile Changes in Pregnant Women with Pre-Eclampsia and Their Correlation with Severety of Pre-Eclampsia |
| title_fullStr | Lipid Profile Changes in Pregnant Women with Pre-Eclampsia and Their Correlation with Severety of Pre-Eclampsia |
| title_full_unstemmed | Lipid Profile Changes in Pregnant Women with Pre-Eclampsia and Their Correlation with Severety of Pre-Eclampsia |
| title_short | Lipid Profile Changes in Pregnant Women with Pre-Eclampsia and Their Correlation with Severety of Pre-Eclampsia |
| title_sort | lipid profile changes in pregnant women with pre eclampsia and their correlation with severety of pre eclampsia |
| topic | : Lipid profile, pregnancy, severe pre-eclampsia |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/766 |
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