The Effects of Chimeric Antigen Receptor (CAR) Hinge Domain Post-Translational Modifications on CAR-T Cell Activity

The Effects of Chimeric Antigen Receptor (CAR) Hinge Domain Post-Translational Modifications on CAR-T Cell Activity

To improve the efficacy and safety of chimeric antigen receptor (CAR)-expressing T cell therapeutics through enhanced CAR design, we analysed CAR structural factors that affect CAR-T cell function. We studied the effects of disulphide bonding at cysteine residues and glycosylation in the HD on CAR-T...

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Bibliographic Details
Main Authors: Sachiko Hirobe, Keisuke Imaeda, Masashi Tachibana, Naoki Okada
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
chimeric antigen receptor
CAR-T cell therapy
disulphide bonds
glycosylation
hinge domain
Online Access:https://www.mdpi.com/1422-0067/23/7/4056

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