Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants
Coordinated programs of gene expression drive brain development. Here, the authors use human embryonic stem cells and foetal cortical tissue as well as available GWAS statistics and analysis of genetic variants associated with neuropsychiatric disorders and cognition revealing a convergence on trans...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-27601-0 |
| _version_ | 1819006653116186624 |
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| author | Bret Sanders Daniel D’Andrea Mark O. Collins Elliott Rees Tom G. J. Steward Ying Zhu Gareth Chapman Sophie E. Legge Antonio F. Pardiñas Adrian J. Harwood William P. Gray Michael C. O’Donovan Michael J. Owen Adam C. Errington Derek J. Blake Daniel J. Whitcomb Andrew J. Pocklington Eunju Shin |
| author_facet | Bret Sanders Daniel D’Andrea Mark O. Collins Elliott Rees Tom G. J. Steward Ying Zhu Gareth Chapman Sophie E. Legge Antonio F. Pardiñas Adrian J. Harwood William P. Gray Michael C. O’Donovan Michael J. Owen Adam C. Errington Derek J. Blake Daniel J. Whitcomb Andrew J. Pocklington Eunju Shin |
| author_sort | Bret Sanders |
| collection | DOAJ |
| description | Coordinated programs of gene expression drive brain development. Here, the authors use human embryonic stem cells and foetal cortical tissue as well as available GWAS statistics and analysis of genetic variants associated with neuropsychiatric disorders and cognition revealing a convergence on transcriptional programs regulating excitatory cortical neurogenesis. |
| first_indexed | 2024-12-21T00:12:06Z |
| format | Article |
| id | doaj.art-42f6d2253f3b4cb0a163dcbb417d1ba0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T00:12:06Z |
| publishDate | 2022-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-42f6d2253f3b4cb0a163dcbb417d1ba02022-12-21T19:22:19ZengNature PortfolioNature Communications2041-17232022-01-0113112110.1038/s41467-021-27601-0Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variantsBret Sanders0Daniel D’Andrea1Mark O. Collins2Elliott Rees3Tom G. J. Steward4Ying Zhu5Gareth Chapman6Sophie E. Legge7Antonio F. Pardiñas8Adrian J. Harwood9William P. Gray10Michael C. O’Donovan11Michael J. Owen12Adam C. Errington13Derek J. Blake14Daniel J. Whitcomb15Andrew J. Pocklington16Eunju Shin17Neuroscience and Mental Health Research Institute, Cardiff UniversityMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff UniversityDepartment of Biomedical Science, University of SheffieldMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff UniversityBristol Medical School, University of BristolNeuroscience and Mental Health Research Institute, Cardiff UniversityNeuroscience and Mental Health Research Institute, Cardiff UniversityMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff UniversityMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff UniversityNeuroscience and Mental Health Research Institute, Cardiff UniversityNeuroscience and Mental Health Research Institute, Cardiff UniversityMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff UniversityNeuroscience and Mental Health Research Institute, Cardiff UniversityNeuroscience and Mental Health Research Institute, Cardiff UniversityMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff UniversityBristol Medical School, University of BristolMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff UniversityNeuroscience and Mental Health Research Institute, Cardiff UniversityCoordinated programs of gene expression drive brain development. Here, the authors use human embryonic stem cells and foetal cortical tissue as well as available GWAS statistics and analysis of genetic variants associated with neuropsychiatric disorders and cognition revealing a convergence on transcriptional programs regulating excitatory cortical neurogenesis.https://doi.org/10.1038/s41467-021-27601-0 |
| spellingShingle | Bret Sanders Daniel D’Andrea Mark O. Collins Elliott Rees Tom G. J. Steward Ying Zhu Gareth Chapman Sophie E. Legge Antonio F. Pardiñas Adrian J. Harwood William P. Gray Michael C. O’Donovan Michael J. Owen Adam C. Errington Derek J. Blake Daniel J. Whitcomb Andrew J. Pocklington Eunju Shin Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants Nature Communications |
| title | Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants |
| title_full | Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants |
| title_fullStr | Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants |
| title_full_unstemmed | Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants |
| title_short | Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants |
| title_sort | transcriptional programs regulating neuronal differentiation are disrupted in dlg2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants |
| url | https://doi.org/10.1038/s41467-021-27601-0 |
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