Synthesis of Novel Nitrogen-Containing Heterocycle Bromophenols and Their Interaction with Keap1 Protein by Molecular Docking
We previously reported 5,2’-dibromo-2,4’,5’-trihydroxydiphenylmethanoe (LM49), a bromophenol analogue that shows strong protection from oxidative stress injury owing to its superior anti-inflammatory, antioxidant, and anti-apoptotic properties. A series of novel nitrogen-containing heterocycle bromo...
Main Authors: | Xiu E. Feng, Qin Jin Wang, Jie Gao, Shu Rong Ban, Qing Shan Li |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2017-12-01
|
Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/22/12/2142 |
Similar Items
-
Lung adenocarcinoma patients with KEAP1 mutation harboring low immune cell infiltration and low activity of immune environment
by: Wanwan Cheng, et al.
Published: (2021-09-01) -
Keap1 Expression for Predicting the Chemoresistance and Prognosis of Advanced
Non-small Cell Lung Cancer
by: Baoshan CAO, et al.
Published: (2012-10-01) -
Bromophenols in Marine Algae and Their Bioactivities
by: Ming Liu, et al.
Published: (2011-07-01) -
Epigenetic Scanning of <i>KEAP1</i> CpG Sites Uncovers New Molecular-Driven Patterns in Lung Adeno and Squamous Cell Carcinomas
by: Federico Pio Fabrizio, et al.
Published: (2020-09-01) -
A bioactive ligand-conjugated iridium(III) metal-based complex as a Keap1–Nrf2 protein-protein interaction inhibitor against acetaminophen-induced acute liver injury
by: Guodong Li, et al.
Published: (2021-12-01)