Effects of energy-based ablation on thyroid function in treating benign thyroid nodules: a systematic review and meta-analysis
Background Whether thyroid function would be affected by ablation remains controversial. This systematic review and meta-analysis aimed to investigate the effects of energy-based ablation on thyroid function in treating benign thyroid nodules. Methods EMBASE, PubMed, Cochrane Library, and Web of Sci...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | International Journal of Hyperthermia |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/02656736.2020.1806362 |
| _version_ | 1831587445968207872 |
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| author | Yuan Fei Yuxuan Qiu Dong Huang Zhichao Xing Zhe Li Anping Su Jingqiang Zhu |
| author_facet | Yuan Fei Yuxuan Qiu Dong Huang Zhichao Xing Zhe Li Anping Su Jingqiang Zhu |
| author_sort | Yuan Fei |
| collection | DOAJ |
| description | Background Whether thyroid function would be affected by ablation remains controversial. This systematic review and meta-analysis aimed to investigate the effects of energy-based ablation on thyroid function in treating benign thyroid nodules. Methods EMBASE, PubMed, Cochrane Library, and Web of Science databases were searched. The mean difference (MD) or standard MD (SMD) was applied to assess changes in thyroid function, thyroglobulin (Tg), and antibodies after ablation. RevMan version 5.3 was used for data synthesis. Results Forty-two studies involving 6380 patients were eligible. The pooled results revealed significant decrease of 1-day thyroid-stimulating hormone (95% CI, −0.67 to −0.14), significant increase of 1-day, 1-week, and 1-month free thyroxine (95% CI, 1.57 to 5.28; 95% CI, 0.61 to 2.42; 95% CI, −0.76 to −0.15), 1-day and 1-week Tg level (95% CI, 0.40 to 0.81; 95% CI, 0.21 to 1.29), 6-month anti-thyroglobulin antibodies (95% CI, 0.02 to 0.26), 1- and 3-month thyroperoxidase antibody (95% CI, 0.02 to 0.22; 95% CI, 0.17 to 0.43), and 1-day, 1-, and 3-month thyrotrophin receptor antibody (95% CI, 0.10 to 0.43; 95% CI, 0.00 to 0.30; 95% CI, 0.13 to 0.36) after ablation. No statistically significant differences were found in these six indicators in the longer term. The results of subgroup analysis were similar to the pooled results. No significant publication bias was found. Conclusions Energy-based ablation was more likely to have negative effects on thyroid function and antibodies and led to transient increase in Tg level in the short term. However, most of the patients would not develop any thyroid dysfunction in the long-term follow-up. |
| first_indexed | 2024-12-17T21:55:00Z |
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| id | doaj.art-42fa0c7c769d42e092fe0babb640f4be |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2024-12-17T21:55:00Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-42fa0c7c769d42e092fe0babb640f4be2022-12-21T21:31:09ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572020-01-013711090110210.1080/02656736.2020.18063621806362Effects of energy-based ablation on thyroid function in treating benign thyroid nodules: a systematic review and meta-analysisYuan Fei0Yuxuan Qiu1Dong Huang2Zhichao Xing3Zhe Li4Anping Su5Jingqiang Zhu6Department of Thyroid and Parathyroid Surgery, West China Hospital, Sichuan UniversityDepartment of Thyroid and Parathyroid Surgery, West China Hospital, Sichuan UniversityDepartment of Respiratory and Critical Care Medicine, West China Hospital, Sichuan UniversityDepartment of Thyroid and Parathyroid Surgery, West China Hospital, Sichuan UniversityDepartment of Thyroid and Parathyroid Surgery, West China Hospital, Sichuan UniversityDepartment of Thyroid and Parathyroid Surgery, West China Hospital, Sichuan UniversityDepartment of Thyroid and Parathyroid Surgery, West China Hospital, Sichuan UniversityBackground Whether thyroid function would be affected by ablation remains controversial. This systematic review and meta-analysis aimed to investigate the effects of energy-based ablation on thyroid function in treating benign thyroid nodules. Methods EMBASE, PubMed, Cochrane Library, and Web of Science databases were searched. The mean difference (MD) or standard MD (SMD) was applied to assess changes in thyroid function, thyroglobulin (Tg), and antibodies after ablation. RevMan version 5.3 was used for data synthesis. Results Forty-two studies involving 6380 patients were eligible. The pooled results revealed significant decrease of 1-day thyroid-stimulating hormone (95% CI, −0.67 to −0.14), significant increase of 1-day, 1-week, and 1-month free thyroxine (95% CI, 1.57 to 5.28; 95% CI, 0.61 to 2.42; 95% CI, −0.76 to −0.15), 1-day and 1-week Tg level (95% CI, 0.40 to 0.81; 95% CI, 0.21 to 1.29), 6-month anti-thyroglobulin antibodies (95% CI, 0.02 to 0.26), 1- and 3-month thyroperoxidase antibody (95% CI, 0.02 to 0.22; 95% CI, 0.17 to 0.43), and 1-day, 1-, and 3-month thyrotrophin receptor antibody (95% CI, 0.10 to 0.43; 95% CI, 0.00 to 0.30; 95% CI, 0.13 to 0.36) after ablation. No statistically significant differences were found in these six indicators in the longer term. The results of subgroup analysis were similar to the pooled results. No significant publication bias was found. Conclusions Energy-based ablation was more likely to have negative effects on thyroid function and antibodies and led to transient increase in Tg level in the short term. However, most of the patients would not develop any thyroid dysfunction in the long-term follow-up.http://dx.doi.org/10.1080/02656736.2020.1806362energy-based ablationthyroid functionthyroglobulin thyroid antibody benign thyroid nodule |
| spellingShingle | Yuan Fei Yuxuan Qiu Dong Huang Zhichao Xing Zhe Li Anping Su Jingqiang Zhu Effects of energy-based ablation on thyroid function in treating benign thyroid nodules: a systematic review and meta-analysis International Journal of Hyperthermia energy-based ablation thyroid function thyroglobulin thyroid antibody benign thyroid nodule |
| title | Effects of energy-based ablation on thyroid function in treating benign thyroid nodules: a systematic review and meta-analysis |
| title_full | Effects of energy-based ablation on thyroid function in treating benign thyroid nodules: a systematic review and meta-analysis |
| title_fullStr | Effects of energy-based ablation on thyroid function in treating benign thyroid nodules: a systematic review and meta-analysis |
| title_full_unstemmed | Effects of energy-based ablation on thyroid function in treating benign thyroid nodules: a systematic review and meta-analysis |
| title_short | Effects of energy-based ablation on thyroid function in treating benign thyroid nodules: a systematic review and meta-analysis |
| title_sort | effects of energy based ablation on thyroid function in treating benign thyroid nodules a systematic review and meta analysis |
| topic | energy-based ablation thyroid function thyroglobulin thyroid antibody benign thyroid nodule |
| url | http://dx.doi.org/10.1080/02656736.2020.1806362 |
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