Influenza H3 hemagglutinin vaccine with scrambled immunodominant epitopes elicits antibodies directed toward immunosubdominant head epitopes

Influenza H3 hemagglutinin vaccine with scrambled immunodominant epitopes elicits antibodies directed toward immunosubdominant head epitopes

ABSTRACT Vaccination is the most effective countermeasure to reduce the severity of influenza. Current seasonal influenza vaccines mainly elicit humoral immunity targeting hemagglutinin (HA). In particular, the amino acid residues around the receptor-binding site in the HA head domain are predominan...

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Bibliographic Details
Main Authors: Shiho Chiba, Huihui Kong, Gabriele Neumann, Yoshihiro Kawaoka
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:mBio
Subjects:
influenza A (H3N2) viruses
universal vaccines
ferret
immunosubdominant epitopes
Online Access:https://journals.asm.org/doi/10.1128/mbio.00622-23

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