Enhanced Diagnostics for Corneal Ectatic Diseases: The Whats, the Whys, and the Hows
There are different fundamental diagnostic strategies for patients with ectatic corneal diseases (ECDs): screening, confirmation of the diagnosis, classification of the type of ECD, severity staging, prognostic assessment, and clinical follow-up. The conscious application of such strategies enables...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/12/3027 |
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| author | Louise Pellegrino Gomes Esporcatte Marcella Q. Salomão Alexandre Batista da Costa Neto Aydano P. Machado Bernardo T. Lopes Renato Ambrósio |
| author_facet | Louise Pellegrino Gomes Esporcatte Marcella Q. Salomão Alexandre Batista da Costa Neto Aydano P. Machado Bernardo T. Lopes Renato Ambrósio |
| author_sort | Louise Pellegrino Gomes Esporcatte |
| collection | DOAJ |
| description | There are different fundamental diagnostic strategies for patients with ectatic corneal diseases (ECDs): screening, confirmation of the diagnosis, classification of the type of ECD, severity staging, prognostic assessment, and clinical follow-up. The conscious application of such strategies enables individualized treatments. The need for improved diagnostics of ECD is related to the advent of therapeutic refractive procedures that are considered prior to keratoplasty. Among such less invasive procedures, we include corneal crosslinking, customized ablations, and intracorneal ring segment implantation. Besides the paradigm shift in managing patients with ECD, enhancing the sensitivity to detect very mild forms of disease, and characterizing the inherent susceptibility for ectasia progression, became relevant for identifying patients at higher risk for progressive iatrogenic ectasia after laser vision correction (LVC). Moreover, the hypothesis that mild keratoconus is a risk factor for delivering a baby with Down’s syndrome potentially augments the relevance of the diagnostics of ECD. Multimodal refractive imaging involves different technologies, including Placido-disk corneal topography, Scheimpflug 3-D tomography, segmental or layered tomography with layered epithelial thickness using OCT (optical coherence tomography), and digital very high-frequency ultrasound (VHF-US), and ocular wavefront. Corneal biomechanical assessments and genetic and molecular biology tests have translated to clinical measurements. Artificial intelligence allows for the integration of a plethora of clinical data and has proven its relevance in facilitating clinical decisions, allowing personalized or individualized treatments. |
| first_indexed | 2024-03-09T17:08:12Z |
| format | Article |
| id | doaj.art-42fd5ebc064c4402b40b01c9db71c0cc |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T17:08:12Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-42fd5ebc064c4402b40b01c9db71c0cc2023-11-24T14:17:28ZengMDPI AGDiagnostics2075-44182022-12-011212302710.3390/diagnostics12123027Enhanced Diagnostics for Corneal Ectatic Diseases: The Whats, the Whys, and the HowsLouise Pellegrino Gomes Esporcatte0Marcella Q. Salomão1Alexandre Batista da Costa Neto2Aydano P. Machado3Bernardo T. Lopes4Renato Ambrósio5Department of Ophthalmology, Federal University of São Paulo, São Paulo 04023, BrazilDepartment of Ophthalmology, Federal University of São Paulo, São Paulo 04023, BrazilBelo Horizonte Evangelical Hospital, Betin Unit, Belo Horizonte 30220-330, BrazilDepartment of Ophthalmology, Federal University of São Paulo, São Paulo 04023, BrazilDepartment of Ophthalmology, Federal University of São Paulo, São Paulo 04023, BrazilDepartment of Ophthalmology, Federal University of São Paulo, São Paulo 04023, BrazilThere are different fundamental diagnostic strategies for patients with ectatic corneal diseases (ECDs): screening, confirmation of the diagnosis, classification of the type of ECD, severity staging, prognostic assessment, and clinical follow-up. The conscious application of such strategies enables individualized treatments. The need for improved diagnostics of ECD is related to the advent of therapeutic refractive procedures that are considered prior to keratoplasty. Among such less invasive procedures, we include corneal crosslinking, customized ablations, and intracorneal ring segment implantation. Besides the paradigm shift in managing patients with ECD, enhancing the sensitivity to detect very mild forms of disease, and characterizing the inherent susceptibility for ectasia progression, became relevant for identifying patients at higher risk for progressive iatrogenic ectasia after laser vision correction (LVC). Moreover, the hypothesis that mild keratoconus is a risk factor for delivering a baby with Down’s syndrome potentially augments the relevance of the diagnostics of ECD. Multimodal refractive imaging involves different technologies, including Placido-disk corneal topography, Scheimpflug 3-D tomography, segmental or layered tomography with layered epithelial thickness using OCT (optical coherence tomography), and digital very high-frequency ultrasound (VHF-US), and ocular wavefront. Corneal biomechanical assessments and genetic and molecular biology tests have translated to clinical measurements. Artificial intelligence allows for the integration of a plethora of clinical data and has proven its relevance in facilitating clinical decisions, allowing personalized or individualized treatments.https://www.mdpi.com/2075-4418/12/12/3027keratoconuscorneal ectasiamultimodal corneal imagingcorneal biomechanicsgenetics |
| spellingShingle | Louise Pellegrino Gomes Esporcatte Marcella Q. Salomão Alexandre Batista da Costa Neto Aydano P. Machado Bernardo T. Lopes Renato Ambrósio Enhanced Diagnostics for Corneal Ectatic Diseases: The Whats, the Whys, and the Hows Diagnostics keratoconus corneal ectasia multimodal corneal imaging corneal biomechanics genetics |
| title | Enhanced Diagnostics for Corneal Ectatic Diseases: The Whats, the Whys, and the Hows |
| title_full | Enhanced Diagnostics for Corneal Ectatic Diseases: The Whats, the Whys, and the Hows |
| title_fullStr | Enhanced Diagnostics for Corneal Ectatic Diseases: The Whats, the Whys, and the Hows |
| title_full_unstemmed | Enhanced Diagnostics for Corneal Ectatic Diseases: The Whats, the Whys, and the Hows |
| title_short | Enhanced Diagnostics for Corneal Ectatic Diseases: The Whats, the Whys, and the Hows |
| title_sort | enhanced diagnostics for corneal ectatic diseases the whats the whys and the hows |
| topic | keratoconus corneal ectasia multimodal corneal imaging corneal biomechanics genetics |
| url | https://www.mdpi.com/2075-4418/12/12/3027 |
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