The Innate Defense in the Zika-Infected Placenta
Zika virus (ZIKV) is an arthropod-borne virus that belongs to the <i>Flaviviridae</i> family, genus <i>Flavivirus</i> and was first isolated 1947 in Uganda, Africa, from the serum of a sentinel Rhesus monkey. Since its discovery, the virus was responsible for major outbreaks...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/11/12/1410 |
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| author | Laíza Vianna Arruda Natália Gedeão Salomão Felipe de Andrade Vieira Alves Kíssila Rabelo |
| author_facet | Laíza Vianna Arruda Natália Gedeão Salomão Felipe de Andrade Vieira Alves Kíssila Rabelo |
| author_sort | Laíza Vianna Arruda |
| collection | DOAJ |
| description | Zika virus (ZIKV) is an arthropod-borne virus that belongs to the <i>Flaviviridae</i> family, genus <i>Flavivirus</i> and was first isolated 1947 in Uganda, Africa, from the serum of a sentinel Rhesus monkey. Since its discovery, the virus was responsible for major outbreaks in several different countries, being linked to severe complications in pregnant women, neonatal birth defects and the congenital zika syndrome. Maternal–fetal transmission of ZIKV can occur in all trimesters of pregnancy, and the role of the placenta and its cells in these cases is yet to be fully understood. The decidua basalis and chorionic villi, maternal–fetal components of the placenta, contain a rich immunological infiltrate composed by Hofbauer cells, mastocytes, dendritic cells and macrophages, primary cells of the innate immune response that have a role that still needs to be better investigated in ZIKV infection. Recent studies have already described several histopathological features and the susceptibility and permissiveness of placenta cells to infection by the Zika virus. In this review, we address some of the current knowledge on the innate immune responses against ZIKV, especially in the placenta. |
| first_indexed | 2024-03-09T15:59:13Z |
| format | Article |
| id | doaj.art-42ffc03fe64e4ca788b69ea0943141d4 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T15:59:13Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-42ffc03fe64e4ca788b69ea0943141d42023-11-24T17:12:12ZengMDPI AGPathogens2076-08172022-11-011112141010.3390/pathogens11121410The Innate Defense in the Zika-Infected PlacentaLaíza Vianna Arruda0Natália Gedeão Salomão1Felipe de Andrade Vieira Alves2Kíssila Rabelo3Interdisciplinary Laboratory of Medical Research, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation, Rio de Janeiro 21040900, BrazilInterdisciplinary Laboratory of Medical Research, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation, Rio de Janeiro 21040900, BrazilDepartment of Histology and Embryology, Roberto Alcantara Gomes Institute of Biology, Rio de Janeiro State University, Rio de Janeiro 20551030, BrazilDepartment of Histology and Embryology, Roberto Alcantara Gomes Institute of Biology, Rio de Janeiro State University, Rio de Janeiro 20551030, BrazilZika virus (ZIKV) is an arthropod-borne virus that belongs to the <i>Flaviviridae</i> family, genus <i>Flavivirus</i> and was first isolated 1947 in Uganda, Africa, from the serum of a sentinel Rhesus monkey. Since its discovery, the virus was responsible for major outbreaks in several different countries, being linked to severe complications in pregnant women, neonatal birth defects and the congenital zika syndrome. Maternal–fetal transmission of ZIKV can occur in all trimesters of pregnancy, and the role of the placenta and its cells in these cases is yet to be fully understood. The decidua basalis and chorionic villi, maternal–fetal components of the placenta, contain a rich immunological infiltrate composed by Hofbauer cells, mastocytes, dendritic cells and macrophages, primary cells of the innate immune response that have a role that still needs to be better investigated in ZIKV infection. Recent studies have already described several histopathological features and the susceptibility and permissiveness of placenta cells to infection by the Zika virus. In this review, we address some of the current knowledge on the innate immune responses against ZIKV, especially in the placenta.https://www.mdpi.com/2076-0817/11/12/1410Zika virusplacentaimmune responseinnate immunity |
| spellingShingle | Laíza Vianna Arruda Natália Gedeão Salomão Felipe de Andrade Vieira Alves Kíssila Rabelo The Innate Defense in the Zika-Infected Placenta Pathogens Zika virus placenta immune response innate immunity |
| title | The Innate Defense in the Zika-Infected Placenta |
| title_full | The Innate Defense in the Zika-Infected Placenta |
| title_fullStr | The Innate Defense in the Zika-Infected Placenta |
| title_full_unstemmed | The Innate Defense in the Zika-Infected Placenta |
| title_short | The Innate Defense in the Zika-Infected Placenta |
| title_sort | innate defense in the zika infected placenta |
| topic | Zika virus placenta immune response innate immunity |
| url | https://www.mdpi.com/2076-0817/11/12/1410 |
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