Study of serum lipase level in pregnant woman presenting with nausea and vomiting
Background: Hyperemesis gravidarum is a complex condition characterized by excessive nausea and vomiting during pregnancy. It presents with various symptoms which include disturbed nutrition, electrolyte imbalance, ketosis and extreme weight loss. The objective of this study is to compare serum lipa...
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| Format: | Article |
| Language: | English |
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Association of Clinical Pathologists of Nepal
2019-03-01
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| Series: | Journal of Pathology of Nepal |
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| Online Access: | https://www.nepjol.info/index.php/JPN/article/view/23374 |
| _version_ | 1819036650651516928 |
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| author | Arun Dhungana Pratigyan Gautam Rosina Manandhar Chanda Karki |
| author_facet | Arun Dhungana Pratigyan Gautam Rosina Manandhar Chanda Karki |
| author_sort | Arun Dhungana |
| collection | DOAJ |
| description | Background: Hyperemesis gravidarum is a complex condition characterized by excessive nausea and vomiting during pregnancy. It presents with various symptoms which include disturbed nutrition, electrolyte imbalance, ketosis and extreme weight loss. The objective of this study is to compare serum lipase, amylase and glucose in Hyperemesis gravidarum with non-pregnant women.
Materials and methods: A total of 100 subjects among which 50 were nonpregnant women as controls and 50 were women with hyperemesis gravidarum as cases were enrolled in the study. Serum lipase, amylase and glucose levels were estimated in all the subjects.
Results: The levels of mean serum lipase were lesser in cases (23.55 ± 4.91U/L) compared to that in controls (25.45 ± 5.97U/L) with p=0.086. However, the levels of mean serum amylase were higher in cases (76.40 ± 33.86 U/L) compared to that in controls (69.66 ± 16.45U/L) with p= 0.210. Serum amylase activity was raised in 8% of the patients whereas the activity of pancreatic lipase was within normal range. Serum glucose levels were lower in cases (84.72 ± 11.28 mg/dl) than that in controls (87.04 ± 10.65 mg/dl) with p=0.293.
Conclusions: From this study we conclude that lipase activity was statistically insignificant in hyperemesis gravidarum. Therefore, pancreatic activities were less affected by hyperemesis gravidarum. So, this condition needs further exploration regarding biochemical basis to minimize the risk associated with it. |
| first_indexed | 2024-12-21T08:08:54Z |
| format | Article |
| id | doaj.art-43008bb305774be7aa40bac2850e47b3 |
| institution | Directory Open Access Journal |
| issn | 2091-0797 2091-0908 |
| language | English |
| last_indexed | 2024-12-21T08:08:54Z |
| publishDate | 2019-03-01 |
| publisher | Association of Clinical Pathologists of Nepal |
| record_format | Article |
| series | Journal of Pathology of Nepal |
| spelling | doaj.art-43008bb305774be7aa40bac2850e47b32022-12-21T19:10:43ZengAssociation of Clinical Pathologists of NepalJournal of Pathology of Nepal2091-07972091-09082019-03-01911480148410.3126/jpn.v9i1.2337423374Study of serum lipase level in pregnant woman presenting with nausea and vomitingArun Dhungana0Pratigyan Gautam1Rosina Manandhar2Chanda Karki3Kathmandu Medical College Teaching HospitalKathmandu Medical College Teaching HospitalKathmandu Medical College Teaching HospitalKathmandu Medical College Teaching HospitalBackground: Hyperemesis gravidarum is a complex condition characterized by excessive nausea and vomiting during pregnancy. It presents with various symptoms which include disturbed nutrition, electrolyte imbalance, ketosis and extreme weight loss. The objective of this study is to compare serum lipase, amylase and glucose in Hyperemesis gravidarum with non-pregnant women. Materials and methods: A total of 100 subjects among which 50 were nonpregnant women as controls and 50 were women with hyperemesis gravidarum as cases were enrolled in the study. Serum lipase, amylase and glucose levels were estimated in all the subjects. Results: The levels of mean serum lipase were lesser in cases (23.55 ± 4.91U/L) compared to that in controls (25.45 ± 5.97U/L) with p=0.086. However, the levels of mean serum amylase were higher in cases (76.40 ± 33.86 U/L) compared to that in controls (69.66 ± 16.45U/L) with p= 0.210. Serum amylase activity was raised in 8% of the patients whereas the activity of pancreatic lipase was within normal range. Serum glucose levels were lower in cases (84.72 ± 11.28 mg/dl) than that in controls (87.04 ± 10.65 mg/dl) with p=0.293. Conclusions: From this study we conclude that lipase activity was statistically insignificant in hyperemesis gravidarum. Therefore, pancreatic activities were less affected by hyperemesis gravidarum. So, this condition needs further exploration regarding biochemical basis to minimize the risk associated with it.https://www.nepjol.info/index.php/JPN/article/view/23374Acetone; Amylase; Gravidarum; Hyperemesis; Lipase |
| spellingShingle | Arun Dhungana Pratigyan Gautam Rosina Manandhar Chanda Karki Study of serum lipase level in pregnant woman presenting with nausea and vomiting Journal of Pathology of Nepal Acetone; Amylase; Gravidarum; Hyperemesis; Lipase |
| title | Study of serum lipase level in pregnant woman presenting with nausea and vomiting |
| title_full | Study of serum lipase level in pregnant woman presenting with nausea and vomiting |
| title_fullStr | Study of serum lipase level in pregnant woman presenting with nausea and vomiting |
| title_full_unstemmed | Study of serum lipase level in pregnant woman presenting with nausea and vomiting |
| title_short | Study of serum lipase level in pregnant woman presenting with nausea and vomiting |
| title_sort | study of serum lipase level in pregnant woman presenting with nausea and vomiting |
| topic | Acetone; Amylase; Gravidarum; Hyperemesis; Lipase |
| url | https://www.nepjol.info/index.php/JPN/article/view/23374 |
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