A Comparison of Solubility, Stability, and Bioavailability between Astilbin and Neoastilbin Isolated from <i>Smilax glabra</i> Rhizoma
Astilbin and neoastilbin are two flavonoid stereoisomers. In the present study, their solubility, stability, and bioavailability were compared in a rat. The results revealed that the water solubility of astilbin and neoastilbin was 132.72 μg/mL and 217.16 μg/mL, respectively. The oil–water distribut...
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MDPI AG
2020-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/20/4728 |
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| author | Dan Zheng Yi-Ting Ruan Zhong-Ping Yin Qing-Feng Zhang |
| author_facet | Dan Zheng Yi-Ting Ruan Zhong-Ping Yin Qing-Feng Zhang |
| author_sort | Dan Zheng |
| collection | DOAJ |
| description | Astilbin and neoastilbin are two flavonoid stereoisomers. In the present study, their solubility, stability, and bioavailability were compared in a rat. The results revealed that the water solubility of astilbin and neoastilbin was 132.72 μg/mL and 217.16 μg/mL, respectively. The oil–water distribution coefficient (log P) of astilbin and neoastilbin in simulated gastric fluid (SGF) was 1.57 and 1.39, and in simulated intestinal fluid (SIF) was 1.09 and 0.98, respectively. In SIF, about 78.6% astilbin remained after 4 h of incubation at 37 °C, while this value was 88.3% for neoastilbin. Most of the degraded astilbin and neoastilbin were isomerized into their cis-trans-isomer, namely neoisoastilbin and isoastilbin, respectively, and the decomposed parts were rare. For bioavailability comparison in a rat, an HPLC method for trace amounts of astilbin and neoastilbin determination in plasma was developed, and the pretreatment of plasma was optimized. A pharmacokinetic study showed that the absolute bioavailability of astilbin and neoastilbin in a rat showed no significant difference with values of 0.30% and 0.28%, respectively. |
| first_indexed | 2024-03-10T15:36:18Z |
| format | Article |
| id | doaj.art-4300e0a55ee94889ba51e73fcd051fb3 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T15:36:18Z |
| publishDate | 2020-10-01 |
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| series | Molecules |
| spelling | doaj.art-4300e0a55ee94889ba51e73fcd051fb32023-11-20T17:10:28ZengMDPI AGMolecules1420-30492020-10-012520472810.3390/molecules25204728A Comparison of Solubility, Stability, and Bioavailability between Astilbin and Neoastilbin Isolated from <i>Smilax glabra</i> RhizomaDan Zheng0Yi-Ting Ruan1Zhong-Ping Yin2Qing-Feng Zhang3Jiangxi Key Laboratory of Natural Product and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, ChinaJiangxi Key Laboratory of Natural Product and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, ChinaJiangxi Key Laboratory of Natural Product and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, ChinaJiangxi Key Laboratory of Natural Product and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, ChinaAstilbin and neoastilbin are two flavonoid stereoisomers. In the present study, their solubility, stability, and bioavailability were compared in a rat. The results revealed that the water solubility of astilbin and neoastilbin was 132.72 μg/mL and 217.16 μg/mL, respectively. The oil–water distribution coefficient (log P) of astilbin and neoastilbin in simulated gastric fluid (SGF) was 1.57 and 1.39, and in simulated intestinal fluid (SIF) was 1.09 and 0.98, respectively. In SIF, about 78.6% astilbin remained after 4 h of incubation at 37 °C, while this value was 88.3% for neoastilbin. Most of the degraded astilbin and neoastilbin were isomerized into their cis-trans-isomer, namely neoisoastilbin and isoastilbin, respectively, and the decomposed parts were rare. For bioavailability comparison in a rat, an HPLC method for trace amounts of astilbin and neoastilbin determination in plasma was developed, and the pretreatment of plasma was optimized. A pharmacokinetic study showed that the absolute bioavailability of astilbin and neoastilbin in a rat showed no significant difference with values of 0.30% and 0.28%, respectively.https://www.mdpi.com/1420-3049/25/20/4728astilbinneoastilbinsolubilitystabilitybioavailability |
| spellingShingle | Dan Zheng Yi-Ting Ruan Zhong-Ping Yin Qing-Feng Zhang A Comparison of Solubility, Stability, and Bioavailability between Astilbin and Neoastilbin Isolated from <i>Smilax glabra</i> Rhizoma Molecules astilbin neoastilbin solubility stability bioavailability |
| title | A Comparison of Solubility, Stability, and Bioavailability between Astilbin and Neoastilbin Isolated from <i>Smilax glabra</i> Rhizoma |
| title_full | A Comparison of Solubility, Stability, and Bioavailability between Astilbin and Neoastilbin Isolated from <i>Smilax glabra</i> Rhizoma |
| title_fullStr | A Comparison of Solubility, Stability, and Bioavailability between Astilbin and Neoastilbin Isolated from <i>Smilax glabra</i> Rhizoma |
| title_full_unstemmed | A Comparison of Solubility, Stability, and Bioavailability between Astilbin and Neoastilbin Isolated from <i>Smilax glabra</i> Rhizoma |
| title_short | A Comparison of Solubility, Stability, and Bioavailability between Astilbin and Neoastilbin Isolated from <i>Smilax glabra</i> Rhizoma |
| title_sort | comparison of solubility stability and bioavailability between astilbin and neoastilbin isolated from i smilax glabra i rhizoma |
| topic | astilbin neoastilbin solubility stability bioavailability |
| url | https://www.mdpi.com/1420-3049/25/20/4728 |
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