Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosis
Macrophages are the preeminent phagocytic cells which control multiple infections. Tuberculosis a leading cause of death in mankind and the causative organism Mycobacterium tuberculosis (MTB) infects and persists in macrophages. Macrophages use reactive oxygen and nitrogen species (ROS/RNS) and auto...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1121495/full |
| _version_ | 1797884398086914048 |
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| author | Kangling Zhang Mark L. Sowers Ellie I. Cherryhomes Vipul K. Singh Abhishek Mishra Blanca I. Restrepo Arshad Khan Chinnaswamy Jagannath |
| author_facet | Kangling Zhang Mark L. Sowers Ellie I. Cherryhomes Vipul K. Singh Abhishek Mishra Blanca I. Restrepo Arshad Khan Chinnaswamy Jagannath |
| author_sort | Kangling Zhang |
| collection | DOAJ |
| description | Macrophages are the preeminent phagocytic cells which control multiple infections. Tuberculosis a leading cause of death in mankind and the causative organism Mycobacterium tuberculosis (MTB) infects and persists in macrophages. Macrophages use reactive oxygen and nitrogen species (ROS/RNS) and autophagy to kill and degrade microbes including MTB. Glucose metabolism regulates the macrophage-mediated antimicrobial mechanisms. Whereas glucose is essential for the growth of cells in immune cells, glucose metabolism and its downsteam metabolic pathways generate key mediators which are essential co-substrates for post-translational modifications of histone proteins, which in turn, epigenetically regulate gene expression. Herein, we describe the role of sirtuins which are NAD+-dependent histone histone/protein deacetylases during the epigenetic regulation of autophagy, the production of ROS/RNS, acetyl-CoA, NAD+, and S-adenosine methionine (SAM), and illustrate the cross-talk between immunometabolism and epigenetics on macrophage activation. We highlight sirtuins as emerging therapeutic targets for modifying immunometabolism to alter macrophage phenotype and antimicrobial function. |
| first_indexed | 2024-04-10T04:07:01Z |
| format | Article |
| id | doaj.art-430127cf2afd426fafd65b8cca7fff42 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T04:07:01Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-430127cf2afd426fafd65b8cca7fff422023-03-13T04:37:22ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-03-011410.3389/fimmu.2023.11214951121495Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosisKangling Zhang0Mark L. Sowers1Ellie I. Cherryhomes2Vipul K. Singh3Abhishek Mishra4Blanca I. Restrepo5Arshad Khan6Chinnaswamy Jagannath7Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, United StatesDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, United StatesDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, United StatesDepartment of Pathology and Genomic Medicine, Houston Methodist Research Institute, Weill-Cornell Medicine, Houston, TX, United StatesDepartment of Pathology and Genomic Medicine, Houston Methodist Research Institute, Weill-Cornell Medicine, Houston, TX, United StatesUniversity of Texas Health Houston, School of Public Health, Brownsville, TX, United StatesDepartment of Pathology and Genomic Medicine, Houston Methodist Research Institute, Weill-Cornell Medicine, Houston, TX, United StatesDepartment of Pathology and Genomic Medicine, Houston Methodist Research Institute, Weill-Cornell Medicine, Houston, TX, United StatesMacrophages are the preeminent phagocytic cells which control multiple infections. Tuberculosis a leading cause of death in mankind and the causative organism Mycobacterium tuberculosis (MTB) infects and persists in macrophages. Macrophages use reactive oxygen and nitrogen species (ROS/RNS) and autophagy to kill and degrade microbes including MTB. Glucose metabolism regulates the macrophage-mediated antimicrobial mechanisms. Whereas glucose is essential for the growth of cells in immune cells, glucose metabolism and its downsteam metabolic pathways generate key mediators which are essential co-substrates for post-translational modifications of histone proteins, which in turn, epigenetically regulate gene expression. Herein, we describe the role of sirtuins which are NAD+-dependent histone histone/protein deacetylases during the epigenetic regulation of autophagy, the production of ROS/RNS, acetyl-CoA, NAD+, and S-adenosine methionine (SAM), and illustrate the cross-talk between immunometabolism and epigenetics on macrophage activation. We highlight sirtuins as emerging therapeutic targets for modifying immunometabolism to alter macrophage phenotype and antimicrobial function.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1121495/fullhuman macrophagesautophagyglycolysismetabolismhistone modificationsSIRTUIN |
| spellingShingle | Kangling Zhang Mark L. Sowers Ellie I. Cherryhomes Vipul K. Singh Abhishek Mishra Blanca I. Restrepo Arshad Khan Chinnaswamy Jagannath Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosis Frontiers in Immunology human macrophages autophagy glycolysis metabolism histone modifications SIRTUIN |
| title | Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosis |
| title_full | Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosis |
| title_fullStr | Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosis |
| title_full_unstemmed | Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosis |
| title_short | Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosis |
| title_sort | sirtuin dependent metabolic and epigenetic regulation of macrophages during tuberculosis |
| topic | human macrophages autophagy glycolysis metabolism histone modifications SIRTUIN |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1121495/full |
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