Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer
<b>:</b><b> </b>In recent years, metal organic frameworks (MOFs) have been widely developed as vehicles for the effective delivery of drugs to tumor tissues. Due to the high loading capacity and excellent biocompatibility of MOFs, they provide an unprecedented opportunity for...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/12/3/232 |
| _version_ | 1811301627309588480 |
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| author | Mengru Cai Gongsen Chen Liuying Qin Changhai Qu Xiaoxv Dong Jian Ni Xingbin Yin |
| author_facet | Mengru Cai Gongsen Chen Liuying Qin Changhai Qu Xiaoxv Dong Jian Ni Xingbin Yin |
| author_sort | Mengru Cai |
| collection | DOAJ |
| description | <b>:</b><b> </b>In recent years, metal organic frameworks (MOFs) have been widely developed as vehicles for the effective delivery of drugs to tumor tissues. Due to the high loading capacity and excellent biocompatibility of MOFs, they provide an unprecedented opportunity for the treatment of cancer. However, drugs which are commonly used to treat cancer often cause side effects in normal tissue accumulation. Therefore, the strategy of drug targeting delivery based on MOFs has excellent research significance. Here, we introduce several intelligent targeted drug delivery systems based on MOFs and their characteristics as drug-loading systems, and the challenges of MOFs are discussed. This article covers the following types of MOFs: Isoreticular Metal Organic Frameworks (IRMOFs), Materials of Institute Lavoisier (MILs), Zeolitic Imidazolate Frameworks (ZIFs), University of Oslo (UiOs), and MOFs-based core-shell structures. Generally, MOFs can be reasonably controlled at the nanometer size to effectively achieve passive targeting. In addition, different ligands can be modified on MOFs for active or physicochemical targeting. On the one hand, the targeting strategy can improve the concentration of the drugs at the tumor site to improve the efficacy, on the other hand, it can avoid the release of the drugs in normal tissues to improve safety. Despite the challenges of clinical application of MOFs, MOFs have a number of advantages as a kind of smart delivery vehicle, which offer possibilities for clinical applications. |
| first_indexed | 2024-04-13T07:12:18Z |
| format | Article |
| id | doaj.art-4303491aaee3488589327b1ac14d90c1 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-13T07:12:18Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-4303491aaee3488589327b1ac14d90c12022-12-22T02:56:50ZengMDPI AGPharmaceutics1999-49232020-03-0112323210.3390/pharmaceutics12030232pharmaceutics12030232Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of CancerMengru Cai0Gongsen Chen1Liuying Qin2Changhai Qu3Xiaoxv Dong4Jian Ni5Xingbin Yin6School of Chinese Material Medical, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Material Medical, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Material Medical, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Material Medical, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Material Medical, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Material Medical, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Material Medical, Beijing University of Chinese Medicine, Beijing 102488, China<b>:</b><b> </b>In recent years, metal organic frameworks (MOFs) have been widely developed as vehicles for the effective delivery of drugs to tumor tissues. Due to the high loading capacity and excellent biocompatibility of MOFs, they provide an unprecedented opportunity for the treatment of cancer. However, drugs which are commonly used to treat cancer often cause side effects in normal tissue accumulation. Therefore, the strategy of drug targeting delivery based on MOFs has excellent research significance. Here, we introduce several intelligent targeted drug delivery systems based on MOFs and their characteristics as drug-loading systems, and the challenges of MOFs are discussed. This article covers the following types of MOFs: Isoreticular Metal Organic Frameworks (IRMOFs), Materials of Institute Lavoisier (MILs), Zeolitic Imidazolate Frameworks (ZIFs), University of Oslo (UiOs), and MOFs-based core-shell structures. Generally, MOFs can be reasonably controlled at the nanometer size to effectively achieve passive targeting. In addition, different ligands can be modified on MOFs for active or physicochemical targeting. On the one hand, the targeting strategy can improve the concentration of the drugs at the tumor site to improve the efficacy, on the other hand, it can avoid the release of the drugs in normal tissues to improve safety. Despite the challenges of clinical application of MOFs, MOFs have a number of advantages as a kind of smart delivery vehicle, which offer possibilities for clinical applications.https://www.mdpi.com/1999-4923/12/3/232metal organic frameworktargeting drug delivery systemnanoparticle |
| spellingShingle | Mengru Cai Gongsen Chen Liuying Qin Changhai Qu Xiaoxv Dong Jian Ni Xingbin Yin Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer Pharmaceutics metal organic framework targeting drug delivery system nanoparticle |
| title | Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer |
| title_full | Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer |
| title_fullStr | Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer |
| title_full_unstemmed | Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer |
| title_short | Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer |
| title_sort | metal organic frameworks as drug targeting delivery vehicles in the treatment of cancer |
| topic | metal organic framework targeting drug delivery system nanoparticle |
| url | https://www.mdpi.com/1999-4923/12/3/232 |
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