In Vitro Drug Repurposing: Focus on Vasodilators
Drug repurposing aims to identify new therapeutic uses for drugs that have already been approved for other conditions. This approach can save time and resources compared to traditional drug development, as the safety and efficacy of the repurposed drug have already been established. In the context o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/4/671 |
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| author | Eduarda Ribeiro Bárbara Costa Francisco Vasques-Nóvoa Nuno Vale |
| author_facet | Eduarda Ribeiro Bárbara Costa Francisco Vasques-Nóvoa Nuno Vale |
| author_sort | Eduarda Ribeiro |
| collection | DOAJ |
| description | Drug repurposing aims to identify new therapeutic uses for drugs that have already been approved for other conditions. This approach can save time and resources compared to traditional drug development, as the safety and efficacy of the repurposed drug have already been established. In the context of cancer, drug repurposing can lead to the discovery of new treatments that can target specific cancer cell lines and improve patient outcomes. Vasodilators are a class of drugs that have been shown to have the potential to influence various types of cancer. These medications work by relaxing the smooth muscle of blood vessels, increasing blood flow to tumors, and improving the delivery of chemotherapy drugs. Additionally, vasodilators have been found to have antiproliferative and proapoptotic effects on cancer cells, making them a promising target for drug repurposing. Research on vasodilators for cancer treatment has already shown promising results in preclinical and clinical studies. However, additionally research is needed to fully understand the mechanisms of action of vasodilators in cancer and determine the optimal dosing and combination therapy for patients. In this review, we aim to explore the molecular mechanisms of action of vasodilators in cancer cell lines and the current state of research on their repurposing as a treatment option. With the goal of minimizing the effort and resources required for traditional drug development, we hope to shed light on the potential of vasodilators as a viable therapeutic strategy for cancer patients. |
| first_indexed | 2024-03-11T09:00:45Z |
| format | Article |
| id | doaj.art-4303bcaff47f4134ab230b5146c2aab5 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T09:00:45Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-4303bcaff47f4134ab230b5146c2aab52023-11-16T19:45:38ZengMDPI AGCells2073-44092023-02-0112467110.3390/cells12040671In Vitro Drug Repurposing: Focus on VasodilatorsEduarda Ribeiro0Bárbara Costa1Francisco Vasques-Nóvoa2Nuno Vale3OncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor Plácido da Costa, 4200-450 Porto, PortugalOncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor Plácido da Costa, 4200-450 Porto, PortugalCardiovascular R&D Center, Faculty of Medicine, University of Porto, Rua Doutor Plácido da Costa, 4200-450 Porto, PortugalOncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor Plácido da Costa, 4200-450 Porto, PortugalDrug repurposing aims to identify new therapeutic uses for drugs that have already been approved for other conditions. This approach can save time and resources compared to traditional drug development, as the safety and efficacy of the repurposed drug have already been established. In the context of cancer, drug repurposing can lead to the discovery of new treatments that can target specific cancer cell lines and improve patient outcomes. Vasodilators are a class of drugs that have been shown to have the potential to influence various types of cancer. These medications work by relaxing the smooth muscle of blood vessels, increasing blood flow to tumors, and improving the delivery of chemotherapy drugs. Additionally, vasodilators have been found to have antiproliferative and proapoptotic effects on cancer cells, making them a promising target for drug repurposing. Research on vasodilators for cancer treatment has already shown promising results in preclinical and clinical studies. However, additionally research is needed to fully understand the mechanisms of action of vasodilators in cancer and determine the optimal dosing and combination therapy for patients. In this review, we aim to explore the molecular mechanisms of action of vasodilators in cancer cell lines and the current state of research on their repurposing as a treatment option. With the goal of minimizing the effort and resources required for traditional drug development, we hope to shed light on the potential of vasodilators as a viable therapeutic strategy for cancer patients.https://www.mdpi.com/2073-4409/12/4/671vasodilatorsrepurposing drugsin vitro |
| spellingShingle | Eduarda Ribeiro Bárbara Costa Francisco Vasques-Nóvoa Nuno Vale In Vitro Drug Repurposing: Focus on Vasodilators Cells vasodilators repurposing drugs in vitro |
| title | In Vitro Drug Repurposing: Focus on Vasodilators |
| title_full | In Vitro Drug Repurposing: Focus on Vasodilators |
| title_fullStr | In Vitro Drug Repurposing: Focus on Vasodilators |
| title_full_unstemmed | In Vitro Drug Repurposing: Focus on Vasodilators |
| title_short | In Vitro Drug Repurposing: Focus on Vasodilators |
| title_sort | in vitro drug repurposing focus on vasodilators |
| topic | vasodilators repurposing drugs in vitro |
| url | https://www.mdpi.com/2073-4409/12/4/671 |
| work_keys_str_mv | AT eduardaribeiro invitrodrugrepurposingfocusonvasodilators AT barbaracosta invitrodrugrepurposingfocusonvasodilators AT franciscovasquesnovoa invitrodrugrepurposingfocusonvasodilators AT nunovale invitrodrugrepurposingfocusonvasodilators |