Plant Toxin-Based Immunotoxins for Cancer Therapy: A Short Overview
Immunotoxins are chimeric proteins obtained by linking a toxin to either an intact antibody or an antibody fragment. Conjugation can be obtained by chemical or genetic engineering, where the latter yields recombinant conjugates. An essential requirement is that the target molecule recognized by the...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2016-06-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2227-9059/4/2/12 |
| _version_ | 1819228907402952704 |
|---|---|
| author | Letizia Polito Alice Djemil Massimo Bortolotti |
| author_facet | Letizia Polito Alice Djemil Massimo Bortolotti |
| author_sort | Letizia Polito |
| collection | DOAJ |
| description | Immunotoxins are chimeric proteins obtained by linking a toxin to either an intact antibody or an antibody fragment. Conjugation can be obtained by chemical or genetic engineering, where the latter yields recombinant conjugates. An essential requirement is that the target molecule recognized by the antibody is confined to the cell population to be deleted, or at least that it is not present on stem cells or other cell types essential for the organism’s survival. Hundreds of different studies have demonstrated the potential for applying immunotoxins to many models in pre-clinical studies and in clinical trials. Immunotoxins can be theoretically used to eliminate any unwanted cell responsible for a pathological condition. The best results have been obtained in cancer therapy, especially in hematological malignancies. Among plant toxins, the most frequently employed to generate immunotoxins are ribosome-inactivating proteins, the most common being ricin. This review summarizes the various approaches and results obtained in the last four decades by researchers in the field of plant toxin-based immunotoxins for cancer therapy. |
| first_indexed | 2024-12-23T11:04:44Z |
| format | Article |
| id | doaj.art-430493a4ea0549a6be46ad13f2b41edd |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-12-23T11:04:44Z |
| publishDate | 2016-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-430493a4ea0549a6be46ad13f2b41edd2022-12-21T17:49:31ZengMDPI AGBiomedicines2227-90592016-06-01421210.3390/biomedicines4020012biomedicines4020012Plant Toxin-Based Immunotoxins for Cancer Therapy: A Short OverviewLetizia Polito0Alice Djemil1Massimo Bortolotti2Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum, University of Bologna, Via San Giacomo 14, 40126 Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum, University of Bologna, Via San Giacomo 14, 40126 Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum, University of Bologna, Via San Giacomo 14, 40126 Bologna, ItalyImmunotoxins are chimeric proteins obtained by linking a toxin to either an intact antibody or an antibody fragment. Conjugation can be obtained by chemical or genetic engineering, where the latter yields recombinant conjugates. An essential requirement is that the target molecule recognized by the antibody is confined to the cell population to be deleted, or at least that it is not present on stem cells or other cell types essential for the organism’s survival. Hundreds of different studies have demonstrated the potential for applying immunotoxins to many models in pre-clinical studies and in clinical trials. Immunotoxins can be theoretically used to eliminate any unwanted cell responsible for a pathological condition. The best results have been obtained in cancer therapy, especially in hematological malignancies. Among plant toxins, the most frequently employed to generate immunotoxins are ribosome-inactivating proteins, the most common being ricin. This review summarizes the various approaches and results obtained in the last four decades by researchers in the field of plant toxin-based immunotoxins for cancer therapy.http://www.mdpi.com/2227-9059/4/2/12immunotoxinimmunotherapyplant toxinsribosome-inactivating proteinscancer therapy |
| spellingShingle | Letizia Polito Alice Djemil Massimo Bortolotti Plant Toxin-Based Immunotoxins for Cancer Therapy: A Short Overview Biomedicines immunotoxin immunotherapy plant toxins ribosome-inactivating proteins cancer therapy |
| title | Plant Toxin-Based Immunotoxins for Cancer Therapy: A Short Overview |
| title_full | Plant Toxin-Based Immunotoxins for Cancer Therapy: A Short Overview |
| title_fullStr | Plant Toxin-Based Immunotoxins for Cancer Therapy: A Short Overview |
| title_full_unstemmed | Plant Toxin-Based Immunotoxins for Cancer Therapy: A Short Overview |
| title_short | Plant Toxin-Based Immunotoxins for Cancer Therapy: A Short Overview |
| title_sort | plant toxin based immunotoxins for cancer therapy a short overview |
| topic | immunotoxin immunotherapy plant toxins ribosome-inactivating proteins cancer therapy |
| url | http://www.mdpi.com/2227-9059/4/2/12 |
| work_keys_str_mv | AT letiziapolito planttoxinbasedimmunotoxinsforcancertherapyashortoverview AT alicedjemil planttoxinbasedimmunotoxinsforcancertherapyashortoverview AT massimobortolotti planttoxinbasedimmunotoxinsforcancertherapyashortoverview |