Triple co-administration of ivermectin, albendazole and praziquantel in zanzibar: a safety study.
BACKGROUND: Public health interventions based on distribution of anthelminthic drugs against lymphatic filariasis (LF), onchocerciasis, soil-transmitted helminthiasis (STH) and schistosomiasis have been implemented separately to date. A better use of available resources might be facilitated by a mor...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2008-01-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC2217668?pdf=render |
| _version_ | 1818338698960306176 |
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| author | Khalfan A Mohammed Hamad J Haji Albis-Francesco Gabrielli Likezo Mubila Gautam Biswas Lester Chitsulo Mark H Bradley Dirk Engels Lorenzo Savioli David H Molyneux |
| author_facet | Khalfan A Mohammed Hamad J Haji Albis-Francesco Gabrielli Likezo Mubila Gautam Biswas Lester Chitsulo Mark H Bradley Dirk Engels Lorenzo Savioli David H Molyneux |
| author_sort | Khalfan A Mohammed |
| collection | DOAJ |
| description | BACKGROUND: Public health interventions based on distribution of anthelminthic drugs against lymphatic filariasis (LF), onchocerciasis, soil-transmitted helminthiasis (STH) and schistosomiasis have been implemented separately to date. A better use of available resources might be facilitated by a more coordinated approach to control such infections, including the possibility of co-administering the three recommended anthelminthic drugs through a single, large-scale intervention. METHODOLOGY/PRINCIPAL FINDINGS: Ivermectin, albendazole and praziquantel were co-administered to 5,055 children and adults living in areas endemic for LF, STH and schistosomiasis in Zanzibar, United Republic of Tanzania, during a pilot intervention aimed at elucidating and quantifying possible side-effects. Subsequently, these drugs were co-administered to about 700,000 individuals during a countrywide intervention targeting a large part of the total population of Zanzibar. Passive and active surveillance measures carried out during both interventions showed that side-effects attributable to the three drugs given at the same time were mild and self-limiting events. CONCLUSIONS/SIGNIFICANCE: Our data suggest that co-administration of ivermectin, albendazole and praziquantel is safe in areas where lymphatic filariasis, soil-transmitted helminthiasis and schistosomiasis are co-endemic and where several rounds of treatment with one or two drugs have been implemented in the past. Passive surveillance measures, however, should be continued and detection, management and reporting of possible side-effects should be considered a key component of any health intervention administering drugs. |
| first_indexed | 2024-12-13T15:15:15Z |
| format | Article |
| id | doaj.art-43057ea73a3743be88c900e4c5245a7f |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-12-13T15:15:15Z |
| publishDate | 2008-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-43057ea73a3743be88c900e4c5245a7f2022-12-21T23:40:43ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352008-01-0121e17110.1371/journal.pntd.0000171Triple co-administration of ivermectin, albendazole and praziquantel in zanzibar: a safety study.Khalfan A MohammedHamad J HajiAlbis-Francesco GabrielliLikezo MubilaGautam BiswasLester ChitsuloMark H BradleyDirk EngelsLorenzo SavioliDavid H MolyneuxBACKGROUND: Public health interventions based on distribution of anthelminthic drugs against lymphatic filariasis (LF), onchocerciasis, soil-transmitted helminthiasis (STH) and schistosomiasis have been implemented separately to date. A better use of available resources might be facilitated by a more coordinated approach to control such infections, including the possibility of co-administering the three recommended anthelminthic drugs through a single, large-scale intervention. METHODOLOGY/PRINCIPAL FINDINGS: Ivermectin, albendazole and praziquantel were co-administered to 5,055 children and adults living in areas endemic for LF, STH and schistosomiasis in Zanzibar, United Republic of Tanzania, during a pilot intervention aimed at elucidating and quantifying possible side-effects. Subsequently, these drugs were co-administered to about 700,000 individuals during a countrywide intervention targeting a large part of the total population of Zanzibar. Passive and active surveillance measures carried out during both interventions showed that side-effects attributable to the three drugs given at the same time were mild and self-limiting events. CONCLUSIONS/SIGNIFICANCE: Our data suggest that co-administration of ivermectin, albendazole and praziquantel is safe in areas where lymphatic filariasis, soil-transmitted helminthiasis and schistosomiasis are co-endemic and where several rounds of treatment with one or two drugs have been implemented in the past. Passive surveillance measures, however, should be continued and detection, management and reporting of possible side-effects should be considered a key component of any health intervention administering drugs.http://europepmc.org/articles/PMC2217668?pdf=render |
| spellingShingle | Khalfan A Mohammed Hamad J Haji Albis-Francesco Gabrielli Likezo Mubila Gautam Biswas Lester Chitsulo Mark H Bradley Dirk Engels Lorenzo Savioli David H Molyneux Triple co-administration of ivermectin, albendazole and praziquantel in zanzibar: a safety study. PLoS Neglected Tropical Diseases |
| title | Triple co-administration of ivermectin, albendazole and praziquantel in zanzibar: a safety study. |
| title_full | Triple co-administration of ivermectin, albendazole and praziquantel in zanzibar: a safety study. |
| title_fullStr | Triple co-administration of ivermectin, albendazole and praziquantel in zanzibar: a safety study. |
| title_full_unstemmed | Triple co-administration of ivermectin, albendazole and praziquantel in zanzibar: a safety study. |
| title_short | Triple co-administration of ivermectin, albendazole and praziquantel in zanzibar: a safety study. |
| title_sort | triple co administration of ivermectin albendazole and praziquantel in zanzibar a safety study |
| url | http://europepmc.org/articles/PMC2217668?pdf=render |
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