Persistent Retinal Microvascular Impairment in COVID-19 Bilateral Pneumonia at 6-Months Follow-Up Assessed by Optical Coherence Tomography Angiography
The purpose of this study was to evaluate the long-term evolution of retinal changes in COVID-19 patients with bilateral pneumonia. A total of 17 COVID-19 patients underwent retinal imaging 6 months after hospital discharge with structural optical coherence tomography (OCT) and optical coherence tom...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/5/502 |
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| author | Valentina Bilbao-Malavé Jorge González-Zamora Manuel Saenz de Viteri Miriam de la Puente Elsa Gándara Anna Casablanca-Piñera Claudia Boquera-Ventosa Javier Zarranz-Ventura Manuel F. Landecho Alfredo García-Layana |
| author_facet | Valentina Bilbao-Malavé Jorge González-Zamora Manuel Saenz de Viteri Miriam de la Puente Elsa Gándara Anna Casablanca-Piñera Claudia Boquera-Ventosa Javier Zarranz-Ventura Manuel F. Landecho Alfredo García-Layana |
| author_sort | Valentina Bilbao-Malavé |
| collection | DOAJ |
| description | The purpose of this study was to evaluate the long-term evolution of retinal changes in COVID-19 patients with bilateral pneumonia. A total of 17 COVID-19 patients underwent retinal imaging 6 months after hospital discharge with structural optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). The parafoveal retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) were significantly thinner in COVID-19 patients at 6 months compared to 0 months (<i>p</i> = <0.001 in both cases). In the optic nerve analysis, a significantly thinner RNFL was observed (<i>p</i> = 0.006) but persisted significantly thickened, compared to controls (<i>p</i> = 0.02). The vascular density (VD) at 6 months persisted significantly decreased when compared to the control group, and no significant differences were found with the 0 months evaluation; in addition, when analyzed separately, women showed a worsening in the VD. Moreover, a significantly greater foveal area zone (FAZ) (<i>p</i> = 0.003) was observed in COVID-19 patients at 6 months, compared to 0 months. The cotton wool spots (CWSs) observed at baseline were no longer present at 6 months, except for one patient that developed new ones. This study demonstrates that some of the previously known microvascular alterations resulting from COVID-19, persist over time and are still evident 6 months after hospital discharge in patients who have suffered from bilateral pneumonia. |
| first_indexed | 2024-03-10T11:44:10Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T11:44:10Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-430a7919baa74fa88695cb431c5e368d2023-11-21T18:13:11ZengMDPI AGBiomedicines2227-90592021-05-019550210.3390/biomedicines9050502Persistent Retinal Microvascular Impairment in COVID-19 Bilateral Pneumonia at 6-Months Follow-Up Assessed by Optical Coherence Tomography AngiographyValentina Bilbao-Malavé0Jorge González-Zamora1Manuel Saenz de Viteri2Miriam de la Puente3Elsa Gándara4Anna Casablanca-Piñera5Claudia Boquera-Ventosa6Javier Zarranz-Ventura7Manuel F. Landecho8Alfredo García-Layana9Department of Opthalmology, Clínica Universidad de Navarra, 31008 Pamplona, SpainDepartment of Opthalmology, Clínica Universidad de Navarra, 31008 Pamplona, SpainDepartment of Opthalmology, Clínica Universidad de Navarra, 31008 Pamplona, SpainDepartment of Opthalmology, Clínica Universidad de Navarra, 31008 Pamplona, SpainDepartment of Opthalmology, Clínica Universidad de Navarra, 31008 Pamplona, SpainInstitut Clínic de Oftalmología (ICOF), Hospital Clínic de Barcelona, 08028 Barcelona, SpainInstitut Clínic de Oftalmología (ICOF), Hospital Clínic de Barcelona, 08028 Barcelona, SpainInstitut Clínic de Oftalmología (ICOF), Hospital Clínic de Barcelona, 08028 Barcelona, SpainCOVID-19 Unit, Clínica Universidad de Navarra, 31008 Pamplona, SpainDepartment of Opthalmology, Clínica Universidad de Navarra, 31008 Pamplona, SpainThe purpose of this study was to evaluate the long-term evolution of retinal changes in COVID-19 patients with bilateral pneumonia. A total of 17 COVID-19 patients underwent retinal imaging 6 months after hospital discharge with structural optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). The parafoveal retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) were significantly thinner in COVID-19 patients at 6 months compared to 0 months (<i>p</i> = <0.001 in both cases). In the optic nerve analysis, a significantly thinner RNFL was observed (<i>p</i> = 0.006) but persisted significantly thickened, compared to controls (<i>p</i> = 0.02). The vascular density (VD) at 6 months persisted significantly decreased when compared to the control group, and no significant differences were found with the 0 months evaluation; in addition, when analyzed separately, women showed a worsening in the VD. Moreover, a significantly greater foveal area zone (FAZ) (<i>p</i> = 0.003) was observed in COVID-19 patients at 6 months, compared to 0 months. The cotton wool spots (CWSs) observed at baseline were no longer present at 6 months, except for one patient that developed new ones. This study demonstrates that some of the previously known microvascular alterations resulting from COVID-19, persist over time and are still evident 6 months after hospital discharge in patients who have suffered from bilateral pneumonia.https://www.mdpi.com/2227-9059/9/5/502SARS-COV-2COVID-19coronavirusretinamicrovascularcotton wool spots |
| spellingShingle | Valentina Bilbao-Malavé Jorge González-Zamora Manuel Saenz de Viteri Miriam de la Puente Elsa Gándara Anna Casablanca-Piñera Claudia Boquera-Ventosa Javier Zarranz-Ventura Manuel F. Landecho Alfredo García-Layana Persistent Retinal Microvascular Impairment in COVID-19 Bilateral Pneumonia at 6-Months Follow-Up Assessed by Optical Coherence Tomography Angiography Biomedicines SARS-COV-2 COVID-19 coronavirus retina microvascular cotton wool spots |
| title | Persistent Retinal Microvascular Impairment in COVID-19 Bilateral Pneumonia at 6-Months Follow-Up Assessed by Optical Coherence Tomography Angiography |
| title_full | Persistent Retinal Microvascular Impairment in COVID-19 Bilateral Pneumonia at 6-Months Follow-Up Assessed by Optical Coherence Tomography Angiography |
| title_fullStr | Persistent Retinal Microvascular Impairment in COVID-19 Bilateral Pneumonia at 6-Months Follow-Up Assessed by Optical Coherence Tomography Angiography |
| title_full_unstemmed | Persistent Retinal Microvascular Impairment in COVID-19 Bilateral Pneumonia at 6-Months Follow-Up Assessed by Optical Coherence Tomography Angiography |
| title_short | Persistent Retinal Microvascular Impairment in COVID-19 Bilateral Pneumonia at 6-Months Follow-Up Assessed by Optical Coherence Tomography Angiography |
| title_sort | persistent retinal microvascular impairment in covid 19 bilateral pneumonia at 6 months follow up assessed by optical coherence tomography angiography |
| topic | SARS-COV-2 COVID-19 coronavirus retina microvascular cotton wool spots |
| url | https://www.mdpi.com/2227-9059/9/5/502 |
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