Comparison of selected prooxidant-antioxidant balance and bone metabolism indicators and BDNF levels between older women with different levels of physical activity
Abstract Background Given a lack of studies precisely indicating how many steps elderly people should take daily for their antioxidant defence, bone metabolism, and cognitive abilities to improve, our study set out to compare the selected antioxidant, prooxidant, bone turnover, and BDNF indicators b...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-023-04205-5 |
| _version_ | 1797556564930854912 |
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| author | Ewa Sadowska-Krępa Adam Rzetecki Izabela Zając-Gawlak Agnieszka Nawrat-Szołtysik Michał Rozpara Wioletta Mikuľáková Agata Stanek Tomasz Pałka |
| author_facet | Ewa Sadowska-Krępa Adam Rzetecki Izabela Zając-Gawlak Agnieszka Nawrat-Szołtysik Michał Rozpara Wioletta Mikuľáková Agata Stanek Tomasz Pałka |
| author_sort | Ewa Sadowska-Krępa |
| collection | DOAJ |
| description | Abstract Background Given a lack of studies precisely indicating how many steps elderly people should take daily for their antioxidant defence, bone metabolism, and cognitive abilities to improve, our study set out to compare the selected antioxidant, prooxidant, bone turnover, and BDNF indicators between elderly women differing in physical activity (PA) measured by the daily number of steps. Methods The PA levels of 62 women aged 72.1 ± 5.4 years were assessed based on their daily number of steps and then were used to allocate the participants to three groups: group I (n = 18; <5,000 steps a day); group II (n = 22; from 5,000 to 9,999 steps a day); and group III (n = 22; ≥10,000 steps a day). Blood samples were collected from the participants in early morning hours and subjected to biochemical analysis for prooxidant-antioxidant balance indicators (SOD, CAT, GPx, GR, GSH, UA, MDA and TOS/TOC), bone metabolism indicators (Ca, 25-OH vitamin D, osteocalcin, CTX-I, and PTH), and BDNF levels. Results The groups were not statistically significantly different in the activity of SOD, CAT, GPx, and GR, but their concentrations of GSH (H = 22.10, p < 0.001) and UA (H = 12.20, p = 0.002) proved to be significantly associated with the groups’ daily PA. The between-group differences in the concentrations of MDA and TOS/TOC were not significant, with both these indicators tending to take higher values in group I than in groups II and III. Significant differences between the groups were established for the concentrations of 25-OH vitamin D (H = 24.21, p < 0.001), osteocalcin (H = 7.88, p = 0.019), CTX-I (H = 12.91, p = 0.002), and BDNF (H = 14.47, p = 0.001), but not for Ca and PTH. Conclusions Significantly higher concentrations of GSH, slightly lower oxidative stress indicators, significantly higher BDNF levels, and moderately better bone turnover indicators and resorption markers in the group taking more than 5,000 steps a day suggest that this level of PA can promote successful aging. More research is, however, needed to confirm this finding. |
| first_indexed | 2024-03-10T17:03:47Z |
| format | Article |
| id | doaj.art-430dbb149091422481480c80a2ebb4a1 |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-03-10T17:03:47Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-430dbb149091422481480c80a2ebb4a12023-11-20T10:51:39ZengBMCBMC Geriatrics1471-23182023-08-0123111010.1186/s12877-023-04205-5Comparison of selected prooxidant-antioxidant balance and bone metabolism indicators and BDNF levels between older women with different levels of physical activityEwa Sadowska-Krępa0Adam Rzetecki1Izabela Zając-Gawlak2Agnieszka Nawrat-Szołtysik3Michał Rozpara4Wioletta Mikuľáková5Agata Stanek6Tomasz Pałka7Institute of Sport Sciences, Department of Biomedical Basis of Physical Activity, Academy of Physical Education in KatowiceInstitute of Sport Sciences, Department of Biomedical Basis of Physical Activity, Academy of Physical Education in KatowiceInstitute of Physiotherapy and Health Sciences, Department of Physiotherapy in Internal Diseases, Academy of Physical Education in KatowiceInstitute of Physiotherapy and Health Sciences, Department of Physiotherapy, Academy of Physical Education in KatowiceInstitute of Sport Sciences, Department of Health-Promoting Physical Activity and Tourism, Academy of Physical Education in KatowiceFaculty of Health Care, Department of Physiotherapy, University of PresovDepartment and Clinic of Internal Medicine, Angiology and Physical Medicine, Faculty of Medical Sciences in Zabrze, Medical University of SilesiaDepartment of Physiology and Biochemistry, Faculty of Physical Education and Sport, University of Physical Education in KrakowAbstract Background Given a lack of studies precisely indicating how many steps elderly people should take daily for their antioxidant defence, bone metabolism, and cognitive abilities to improve, our study set out to compare the selected antioxidant, prooxidant, bone turnover, and BDNF indicators between elderly women differing in physical activity (PA) measured by the daily number of steps. Methods The PA levels of 62 women aged 72.1 ± 5.4 years were assessed based on their daily number of steps and then were used to allocate the participants to three groups: group I (n = 18; <5,000 steps a day); group II (n = 22; from 5,000 to 9,999 steps a day); and group III (n = 22; ≥10,000 steps a day). Blood samples were collected from the participants in early morning hours and subjected to biochemical analysis for prooxidant-antioxidant balance indicators (SOD, CAT, GPx, GR, GSH, UA, MDA and TOS/TOC), bone metabolism indicators (Ca, 25-OH vitamin D, osteocalcin, CTX-I, and PTH), and BDNF levels. Results The groups were not statistically significantly different in the activity of SOD, CAT, GPx, and GR, but their concentrations of GSH (H = 22.10, p < 0.001) and UA (H = 12.20, p = 0.002) proved to be significantly associated with the groups’ daily PA. The between-group differences in the concentrations of MDA and TOS/TOC were not significant, with both these indicators tending to take higher values in group I than in groups II and III. Significant differences between the groups were established for the concentrations of 25-OH vitamin D (H = 24.21, p < 0.001), osteocalcin (H = 7.88, p = 0.019), CTX-I (H = 12.91, p = 0.002), and BDNF (H = 14.47, p = 0.001), but not for Ca and PTH. Conclusions Significantly higher concentrations of GSH, slightly lower oxidative stress indicators, significantly higher BDNF levels, and moderately better bone turnover indicators and resorption markers in the group taking more than 5,000 steps a day suggest that this level of PA can promote successful aging. More research is, however, needed to confirm this finding.https://doi.org/10.1186/s12877-023-04205-5Antioxidant enzymesNon-enzymatic antioxidantsOxidative stressBone turnoverBrain-derived neurotrophic factorAging |
| spellingShingle | Ewa Sadowska-Krępa Adam Rzetecki Izabela Zając-Gawlak Agnieszka Nawrat-Szołtysik Michał Rozpara Wioletta Mikuľáková Agata Stanek Tomasz Pałka Comparison of selected prooxidant-antioxidant balance and bone metabolism indicators and BDNF levels between older women with different levels of physical activity BMC Geriatrics Antioxidant enzymes Non-enzymatic antioxidants Oxidative stress Bone turnover Brain-derived neurotrophic factor Aging |
| title | Comparison of selected prooxidant-antioxidant balance and bone metabolism indicators and BDNF levels between older women with different levels of physical activity |
| title_full | Comparison of selected prooxidant-antioxidant balance and bone metabolism indicators and BDNF levels between older women with different levels of physical activity |
| title_fullStr | Comparison of selected prooxidant-antioxidant balance and bone metabolism indicators and BDNF levels between older women with different levels of physical activity |
| title_full_unstemmed | Comparison of selected prooxidant-antioxidant balance and bone metabolism indicators and BDNF levels between older women with different levels of physical activity |
| title_short | Comparison of selected prooxidant-antioxidant balance and bone metabolism indicators and BDNF levels between older women with different levels of physical activity |
| title_sort | comparison of selected prooxidant antioxidant balance and bone metabolism indicators and bdnf levels between older women with different levels of physical activity |
| topic | Antioxidant enzymes Non-enzymatic antioxidants Oxidative stress Bone turnover Brain-derived neurotrophic factor Aging |
| url | https://doi.org/10.1186/s12877-023-04205-5 |
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